iiinova — where your digital self keeps evolving

Reposted by Jimmy Gollihar

Jesse Erasmus @jesseerasmus.bsky.social · 20/12/2024

Another update on our #CCHF vaccine that is marching towards phase I clinical trial. Here we report on the durability of protection in a mouse model of CCHFV infection. Excellent work from our colleagues at RML/NIAID🧪 www.nature.com/articles/s41...

nature.com

Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice - npj Vaccines

npj Vaccines - Replicating RNA vaccine confers durable immunity against Crimean Congo hemorrhagic fever virus challenge in mice

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Reposted by Jimmy Gollihar

Saskia Popescu @saskiapopescu.bsky.social · 04/12/2024

“Infected people had flu-like symptoms including high fever and severe headaches, Remy Saki, the deputy governor of Kwango province, and Apollinaire Yumba, the provincial minister of health, said on Monday.

theguardian.com

Unknown disease kills 143 people in south-west DRC, local authorities say

Infected people described as having flu-like symptoms including high fever and severe headaches

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Reposted by Jimmy Gollihar

amelie-iska @amelie-iska.bsky.social · 23/11/2024

More comments on Boltz-1 Mmseqs2-GPU integration is super fast. Helped a ton with an enzyme-substrate pair. It’s much better quality software engineering than most academic models and easy to use. Thanks @gcorso.bsky.social, you guys did great. I put some fun logos on OpenBioML you might find fun.

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Reposted by Jimmy Gollihar

Edward Marcotte @edwardmarcotte.bsky.social · 21/11/2024

Question for the #CryoEM crowd: does anyone happen to recognize this lovely ~10-15nm diameter protein complex we stumbled across while imaging slime mold protein lysate (as one does)?

Cryo-electron micrograph image (or more properly, the average of 1,236 such images) of a 6-pointed star-shaped protein complex found in the interior of slime mold cells.

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Reposted by Jimmy Gollihar

Gabriele Corso @gcorso.bsky.social · 17/11/2024

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

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Jesse Erasmus @jesseerasmus.bsky.social · 17/11/2024

New paper from Amit Khandhar’s team at HDT Bio demonstrating that our LION/repRNA platform can be thermostabilized by lyophilization, enabling refrigerator stability for at least 1 year! Clear implications for global access to vaccines based on our technology. authors.elsevier.com/c/1k6n4cI2-5...

Graphical abstract of the published manuscript.

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Reposted by Jimmy Gollihar

Jason McLellan @mclellanlab.bsky.social · 13/11/2024

My graduate student Nasim Abdi just won 2nd place for her poster at the International Conference for Pandemic Preparedness in Trieste, Italy! www.pathogen-ri.eu/conference/. Great collaboration with @drjimmydale.bsky.social at Houston Methodist🤝

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