Sign in

Maria Antonietta Tosches

@matosches.bsky.social
358 followers 334 following 33 posts

Associate Professor @ Columbia University. Brain evolution, plasticity and regeneration. www.tosches-lab.com

PostsRepliesMedia
Reposted by Maria Antonietta Tosches
David Schoppik @schoppik.com · 07/10/2026
If you've ever wondered how the brain *really* keeps things in mind, come let Aaron, Nick & their colleagues in the Nagel lab tell you how the fly does it here: www.nature.com/articles/s41...
nature.com
A split attractor design for rapidly writing a navigational goal - Nature
The recurrent h∆K–PFG neural circuit generates persistent heading memories through slow excitation, fast inhibition and a disinhibitory gate, where disinhibition controls the functional...
59035
Reposted by Maria Antonietta Tosches
Barbara Mellone 🇺🇦 @centromellone.bsky.social · 05/10/2026
An other example of the value and beauty of fundamental biology research: we don’t always know what kind of future applications will be made possible by a basic discovery. This work in a single-celled alga open the doors to optigenetics 💡🧬
14817
Reposted by Maria Antonietta Tosches
Andrew Iwaniuk @evoneuro.bsky.social · 05/10/2026
The answer to this question is a very loud and resounding NO. And neurobiologists don't just consider the notion of a "lizard brain" in humans misleading. It is wrong. Very wrong. The only lizard brain is that found within lizards. #neuroethology #neuroskyence www.theguardian.com/science/2026...
theguardian.com
Do humans really have a ‘lizard brain’ lurking beneath our rational minds?
It’s a powerful analogy that captured the popular imagination, but the biological reality is quite different
34714
Maria Antonietta Tosches @matosches.bsky.social · 03/10/2026
Come to be my colleague! We have a broad search for a tenure track position in the Department of Biological Sciences at Columbia. Amazing students and collegial environment in the ❤️ of NYC jobs.sciencecareers.org/job/680518/t...
jobs.sciencecareers.org
Tenure-track, Assistant Professor, Department of Biological Sciences - New York City, New York (US) job with Columbia University Department of Biological Sciences | 680518
The Department of Biological Sciences at Columbia University invites applications for a tenure-track, Assistant Professor position. The successful ...
1177
Reposted by Maria Antonietta Tosches
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 29/09/2026
Atlas of adult Danionella fish telencephalon reveals retention of larval characters www.biorxiv.org/content/10.64898/20…
086
Reposted by Maria Antonietta Tosches
Cajal Club @cajalclub.bsky.social · 30/09/2026
The Cajal Club remembers neuroscientist Barbara L. Finlay, whose pioneering research advanced our understanding of brain development, evolution, and the cerebral cortex. We honor her remarkable scientific legacy, mentorship, and friendship. #Neuroscience #Cajal www.cajalclub.org/in-memoriam-...
cajalclub.org
In Memoriam: Barbara Finlay
The Cajal Club remembers Barbara L. Finlay, an influential developmental and evolutionary neuroscientist whose pioneering research transformed our understanding of brain evolution and development, and...
095
Reposted by Maria Antonietta Tosches
bioRxiv Genetics @biorxiv-genetic.bsky.social · 28/09/2026
Generation of a transgenic cephalopod www.biorxiv.org/content/10.64898/20…
098
Reposted by Maria Antonietta Tosches
John Tuthill @tuthill.bsky.social · 26/09/2026
this story about @couchmicroscopy.bsky.social captures science at its best: a scrappy team, a homemade microscope in a motel room, working under funding duress, pursuing a fundamental question about the evolution of photosynthetic organelles. www.nytimes.com/2026/09/26/s...
nytimes.com
In an $80 Motel Room, a Discovery to Shed Light on the Origins of Life
A scrappy science project led to a significant discovery: two new species of a rare organism that could elucidate a fundamental transition in the history of life on our planet.
24711
Reposted by Maria Antonietta Tosches
Portugues Lab @portugueslab.bsky.social · 24/09/2026
The Department of Neurobiology and Behavior at Cornell University is hiring! Come and do cutting edge research on the neural basis of natural behaviors at NBB (nbb.cornell.edu). No animal too small, no behavior too strange! Apply here: academicjobsonline.org/ajo/jobs/32592
14835
Reposted by Maria Antonietta Tosches
EMBL @embl.org · 21/09/2026
There is still time to apply for the EMBL International PhD Programme! 📢 Don’t miss this opportunity to receive dedicated mentoring while doing interdisciplinary research. Research groups across EMBL are recruiting now! bit.ly/4x9Edss
01432
Reposted by Maria Antonietta Tosches
Justus Kebschull @justuskebschull.bsky.social · 21/09/2026
NEW PREPRINT! An evo-devo look at how new cerebellar nuclei are made. Spoiler: it’s all driven by region-specific excitatory progenitors in the early rhombic lip; inhibitory neurons fill in later. If you care about brain evolution or cerebellar development, check it out: tinyurl.com/CNdevelopment
26127
Reposted by Maria Antonietta Tosches
Pawel Burkhardt @pawelburkhardt.bsky.social · 16/09/2026
Lovely to see several pieces of our ctenophore work featured in this beautiful new story from @quantamagazine.org 🪼 Great piece by @mstarling.bsky.social, also featuring work by @stevehaddock.bsky.social, @arnausebe.bsky.social & @hejnol.bsky.social. www.quantamagazine.org/ctenophores-...
quantamagazine.org
Ctenophores Aren’t Just Beautiful. They’re Biological Wonders. | Quanta Magazine
Comb jellies are helping answer fundamental questions in biology, from how the earliest nervous systems evolved to how bioluminescence works.
27532
Reposted by Maria Antonietta Tosches
Josh Barber @joshbarbershop.bsky.social · 15/09/2026
Lanternfish and the Deep Scattering Layer! Go check out the episode with @drandrewthaler.bsky.social ! #deepsea #ocean #fish #aquarium #science
0167
Reposted by Maria Antonietta Tosches
Andres Bendesky @bendeskylab.com · 11/09/2026
We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
082105
Reposted by Maria Antonietta Tosches
Luis Alberto Bezares Calderón @lbezarescalderon.bsky.social · 16/08/2026
Our team is recruiting a PhD student to investigate the evolution of pressure sensation in Zooplankton! The project will use marine invertebrate larvae to explore the molecular, cellular, and neuronal mechanisms behind this fascinating sensory system. More details here: bit.ly/3TTeF4Q
bit.ly
12825
Reposted by Maria Antonietta Tosches
salamandermeeting2026.bsky.social @salamander2026.bsky.social · 14/08/2026
Join us! #SalamanderMeeting2026 REGISTRATIONS OPEN!! 🔽🔽🔽🔽🔽🔽🔽 salamander2026.iibiomedicas.unam.mx/inicio
043
Reposted by Maria Antonietta Tosches
kdelmore.bsky.social @kdelmore.bsky.social · 28/07/2026
🧠🧬🦤 Excited to be at #ICN2026! We're recruiting a #postdoc to study the neural and molecular basis of migration. Projects could include field experiments, captive studies, and spatial/single-cell. Stop by poster 72 today or email! @zuckermanbrain.bsky.social #neuroethology delmorelab.com/recruitment
087
Maria Antonietta Tosches @matosches.bsky.social · 28/07/2026
Yes! Changes of the tail morphology have been reported in the same species and also in other newts
011
Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
Andrew will present our work on environmental plasticity in newts, which we just posted on bioRxiv. More in the thread below: bsky.app/profile/mato...
000
Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
Newts do not recapitulate what happened in ancient tetrapods, but may use similar mechanisms by convergence. By studying plasticity at the water-to-land interface, we can learn how nervous systems and behaviors are shaped by the different physical forces of terrestrial and aquatic environments. 🧵5/5
050
Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
In the olfactory system, cell types in the nose change in specific ways: support cells change their transcriptomes, and stem cells upregulate neurogenesis. With more olfactory sensory neurons, animals can smell better on land, where odors diffuse more rapidly compared to water. 🧵4/5
130
Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
... and that is when we saw the transformation! The tails, heads, and behavior of these animals changed! And the changes were fully reversible upon return to water. These animals react to the environment they live in with plasticity across scales, from gene expression to morphology and behavior 🧵3/5
130
Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
Newts are a subfamily of salamanders with a semiaquatic lifestyle, but the Iberian ribbed newt Pleurodeles has been historically kept in the lab in fully aquatic conditions... until we decided to place some adult animals in a terrestrial setup for a control experiment... 🧵2/5
110
Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
Excited to share a new preprint from the lab, by @andrewmatheson.bsky.social and team, where we dive into the superpower of newts: plasticity! www.biorxiv.org/content/10.6... Like many good projects, this started with a serendipitous observation... 🧵1/5
68246
Maria Antonietta Tosches @matosches.bsky.social · 27/07/2026
Congratulations to lab members @andrewmatheson.bsky.social , Tori Saltz and recent alumna @ecbjaeger.bsky.social on their #ICN2026 awards! Keep an eye on these rising stars and don't miss Andrew's and Tori's talks at @neuroethology.org this week
1122
Reposted by Maria Antonietta Tosches
Luis Guerra @luisguerra.bsky.social · 06/07/2026
Prebilaterian Origin of Monoaminergic Signalling is out! This paper represents four years of work, not only mine, but friends and colleagues. I am particularly grateful to Tatiana Mayorova; without her help, this paper would not have been nearly as complete. www.sciencedirect.com/science/arti...
sciencedirect.com
Prebilaterian origin of monoaminergic signaling
Monoamines such as serotonin, dopamine, and tyramine regulate physiological and behavioral processes in bilaterian animals, but the evolutionary origi…
43118
Reposted by Maria Antonietta Tosches
Emre Yaksi @emreyaksi.bsky.social · 02/07/2026
I am excited to announce the latest paper from our lab, published in Science ! In this study, we show that thalamocortical-like circuits in the zebrafish brain process sensory information hierarchically across topographically organized forebrain circuits.
science.org
Hierarchical sensory processing in zebrafish thalamocortical-like circuits
Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian...
1311837
Maria Antonietta Tosches @matosches.bsky.social · 30/06/2026
It is a huge honor to become an EMBO Associate Member. I am grateful to my mentors and to all the brilliant trainees in my lab.
3181
Maria Antonietta Tosches @matosches.bsky.social · 29/06/2026
This work is the demonstration of how research with potential translational impact builds on basic science, and of how explorations of animal diversity can fuel new discovery. 🧵7/7
040
Maria Antonietta Tosches @matosches.bsky.social · 29/06/2026
After a mechanical injury, the salamander pallium regenerates early-born neurons, that would otherwise never form during the physiological process of adult neurogenesis. This suggests that the regeneration superpowers of salamanders rely on stem cell plasticity mechanisms that await discovery 🧵6/7
140
Maria Antonietta Tosches @matosches.bsky.social · 29/06/2026
This deeper understanding of development in the salamander brain was also foundational for our first study on brain #regeneration, led by @alonso-ortegag.bsky.social, where we show that brain regeneration is not a simple amplification of adult neurogenesis... 🧵5/7 www.biorxiv.org/content/10.6...
biorxiv.org
Glial cell states bias the regeneration of neuron types across the newt life cycle
Salamanders have outstanding regenerative abilities, which tend to decline in post-metamorphic life stages. Among various tissues, these amphibians can regenerate the brain from ependymoglia cells, an...
172
Maria Antonietta Tosches @matosches.bsky.social · 29/06/2026
These results instigated our search for Cajal-Retzius cells across vertebrates; the paper is now in @currentbiology.bsky.social with a nice perspective piece from @borrell-lab.bsky.social, adding to @fredcauseret.bsky.social's previous piece in Development 🧵4/7 www.sciencedirect.com/science/arti...
sciencedirect.com
Evolutionary origins and transcriptomic innovations of vertebrate Cajal-Retzius cells
Evolutionary changes in cortical development were instrumental in the emergence of the mammalian neocortex. Cajal-Retzius cells, a transient neuron ty…
141
Maria Antonietta Tosches @matosches.bsky.social · 29/06/2026
... except for the fact that the amphibian pallium develops outside-in, instead of inside-out. This work was a great collaboration with @saketkc.bsky.social Rahul Satija, Connor Lynch and @chr-mayer.bsky.social . 🧵3/7
120
Maria Antonietta Tosches @matosches.bsky.social · 29/06/2026
In this manuscript, we show that the amphibian pallium also has neuronal layers, with neuron types generated sequentially during development with distinct transcriptomes and projections. These layers develop according to principles similar to those governing mammalian cortical development... 🧵2/7
130
Maria Antonietta Tosches @matosches.bsky.social · 29/06/2026
Better late than never... an update on the recent work from the lab. First of all, the Foundation: @astridd93.bsky.social phenomenal paper on the evolution of layering in the cerebral cortex 🧵1/7 www.biorxiv.org/content/10.1...
13215
Reposted by Maria Antonietta Tosches
Matthew Cobb @matthewcobb.bsky.social · 24/06/2026
I disagree. Is head is full of tadpoley thoughts, unknown and unimaginable.
1113
Maria Antonietta Tosches @matosches.bsky.social · 29/05/2026
Congratulations Henrik! Amazing news!
110
Maria Antonietta Tosches @matosches.bsky.social · 11/04/2026
Looking forward to presenting our latest work in Seattle!
010
Reposted by Maria Antonietta Tosches
Giordano Lippi @lippilab.bsky.social · 24/02/2026
Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com. www.nature.com/articles/s41... Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️
nature.com
Single-cell and isoform-specific translational profiling of the mouse brain - Nature
Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...
13821
Reposted by Maria Antonietta Tosches
Steven Salzberg @stevensalzberg.bsky.social · 16/01/2026
very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
embl.org
In remembrance of Peer Bork  | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
1014581
Maria Antonietta Tosches @matosches.bsky.social · 09/01/2026
Thank you @fredcauseret.bsky.social for this nice highlight of our work and @idoiaeu.bsky.social 's!
092
Maria Antonietta Tosches @matosches.bsky.social · 17/12/2025
This is so true!
010
Maria Antonietta Tosches @matosches.bsky.social · 16/11/2025
Excited to present our recent work at #SfN25 's Evolutionary Neurogenomics session this Tuesday!
063
Reposted by Maria Antonietta Tosches
Andres Bendesky @bendeskylab.com · 21/10/2025
New faculty job opening at @zuckermanbrain.bsky.social @columbiauniversity.bsky.social Come be our colleague! Application deadline: November 22 apply.interfolio.com/176153
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
11711
Maria Antonietta Tosches @matosches.bsky.social · 04/09/2025
Looking forward to speaking at the next TIBBE seminar!
061
Reposted by Maria Antonietta Tosches
eLife @elife.bsky.social · 01/09/2025
Scientists have mapped the entire connectome of a 3-day-old marine worm larva (Platynereis dumerilii), including over 9,000 cells and 200+ neuronal types. This resource can help us understand how nervous systems evolved and coordinate whole-body movement. buff.ly/IPxFCHs
0186
Maria Antonietta Tosches @matosches.bsky.social · 01/09/2025
We haven't explored this yet, but it is definitely an important question, and the Lamanna dataset would be the natural starting point.
010
Maria Antonietta Tosches @matosches.bsky.social · 25/08/2025
If you want to learn more about the evolution of this fascinating cell type, make sure to also check out the beautiful study by @idoiaeu.bsky.social‬ on sharks www.biorxiv.org/content/10.1... end 🧵
biorxiv.org
Developmental landscape of shark telencephalon sheds light on the evolution of telencephalic cell types and the ancient origin of Cajal-Retzius cells
The emergence of predation and associated complex behaviors in jawed vertebrates (gnathostomes) have been major driving forces in brain evolution. To gain insight into the neuronal complexity of the l...
141
Maria Antonietta Tosches @matosches.bsky.social · 25/08/2025
Interestingly, Cajal-Retzius cells are VERY similar at the transcriptomic level to another ancestral cell type, the external tufted cell in the olfactory bulb. This suggests that Cajal-Retzius cells may have evolved in early vertebrates from cells involved in olfactory processing. 🧵 6/7
170
Maria Antonietta Tosches @matosches.bsky.social · 25/08/2025
next, Eli and @giacomogattoni.bsky.social‬ hunted Cajal-Retzius cells in chicken 🐓 and three species of fish 🐟, to show that yes, this is an ancestral cell type in the vertebrate brain. 🧵 5/7
120