The authors develop a high-throughput platform to quantify programmed ribosomal frameshifting inhibition by large libraries of protein variants. They identify residues essential for the activity of th...

Using massively parallel reporter assays of mini-genes with variable promoters and cassette exon sequences, the authors show that promoter identity is a major determinant of alternative splicing, shap...

An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...