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Mark Oblivious 🧬🧫🔬

@markhill.bsky.social
195 followers 196 following 188 posts

Mass spectrometrist helping deliver safer and more effective biopharmaceuticals

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 06/10/2026
What if mass spectrometry finds a protein sequence that isn’t actually encoded in the DNA? That is the intriguing analytical problem raised by a new Nature Cell Biology study on mistranslation in cancer. lnkd.in/p/e4wbzhsM
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 01/10/2026
The Podcast 3000 youtu.be/fnGaf0p9x1U?...
youtu.be
The DJ 3000
YouTube video by Eddie Bannon
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 10/09/2026
To add "The computer scientist widely known as the "Godfather of AI," Geoffrey Hinton, has stated that a 10% to 20% chance of AI triggering human extinction over the next few decades is "not unreasonable". "!!!!!!
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 16/08/2026
www.linkedin.com/posts/mark-h...
linkedin.com
#medicalethics #medicine #pharmacology #patientsafety #sciencehistory #thesimpsons #elvispresley | Mark Hilliard
“Hi, everybody!” 🩺 One of Springfield’s most questionable doctors has a surprisingly real origin. And the story connects The Simpsons, Elvis Presley, prescription medicines and medical ethics. On t...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 16/08/2026
“Hi, everybody!” 🩺 One of Springfield’s most questionable doctors has a surprisingly real origin. And the story connects The Simpsons, Elvis Presley, prescription medicines and medical ethics. On this day, 16 August 1977, Elvis Presley died at the age of 42.
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 12/08/2026
🧀What if we could measure cheese ripening one proteoform at a time? 🔬 Dolman et al. show how intact-protein LC-HRMS can turn αS1-casein hydrolysis during mozzarella ripening into a quantitative kinetic measurement. Link www.linkedin.com/posts/mark-h...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 01/08/2026
There is a story there!
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 29/07/2026
Ah, OK good to know 😀
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 29/07/2026
Ironic coming from America
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 18/07/2026
Are you getting the monorail system to deliver samples?
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 18/07/2026
We reviewed them, don't think the system can handle LC and MS even though they say they can. Also very expensive, but its a cool system amdd has it areas US anaerobic Lab has a automated workflow
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 09/07/2026
I am Irish, and I'm used to summers where the rain gets slightly warmer! 😅
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 09/07/2026
As someone who is currently in the southwest of France, I can attest to that ! 🥵🔥
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 10/06/2026
I been told duty cycle is reduced to around 60%
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 08/06/2026
Link broken ?
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 31/05/2026
Do we know what he reads
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 26/05/2026
Oh, it’s not a paper — just a core lab in a university. I don’t think they’re using DMSO supercharging. I suspect it’s an analytical C18 column running at around 200 µL/min with TFA for protomics workflow
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 25/05/2026
Good point, but apparently they’re using analytical flow, so no trapping. Very odd, especially as they’re running on an Ascend with 30 min gradients. They compared TFA vs formic acid and saw the same result, so I wonder if residual TFA carryover/suppression could be involved.
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 25/05/2026
@benneely.com @proteomicsnews.bsky.social , Do people still frequently run protomics methods with TFA, heard of one today, 30 minute gradients. Would have thought FA would be standard partices 🤔
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 15/05/2026
static.klipy.com
Dua Lipa Saying Hi
ALT: Dua Lipa Saying Hi
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 14/05/2026
static.klipy.com
Sebastian Sings 'Under The Sea'
ALT: Sebastian Sings 'Under The Sea'
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 24/04/2026
Nice work @cashwood.proteaglyco.com pubs.acs.org/doi/10.1021/...
pubs.acs.org
Anion Supercharging Enables Structural Analysis of Oxidatively Released O-Glycans
O-glycan analysis faces analytical challenges due to poor fragmentation characteristics of oxidatively released O-glycan acids, which can preserve labile O-acetyl modifications but suffer from charge ...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 13/04/2026
'Today at the X-Omics festival a novel fragmentation technique with Extremely High Energetic photons is presented for the first time. A commercial Q-Exactive was upgraded with this light source and new fragmentation spectra were presented."
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 01/04/2026
media.tenor.com
a man and a woman are standing next to each other and the woman is wearing a skeleton tank top .
ALT: a man and a woman are standing next to each other and the woman is wearing a skeleton tank top .
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 25/03/2026
Such sad news, 😔
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Reposted by Mark Oblivious 🧬🧫🔬
Cian Duffy @everypubindublin.ie · 25/03/2026
Tragic news of the passing of Alex Lawes from Whiplash/Fidelity, but who also was the head brewer at Rye River as they became a behemoth in the domestic industry: www.instagram.com/p/DWTmUMqjCs4
instagram.com
Instagram
Create an account or log in to Instagram - Share what you're into with the people who get you.
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 20/03/2026
Happy Bock Day www.linkedin.com/posts/mark-h...
linkedin.com
#bockbeer #beerhistory #lager #craftbeer #germanbeer #lent #easter… | Mark Hilliard
🍺 𝗛𝗮𝗽𝗽𝘆 𝗡𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗕𝗼𝗰𝗸 𝗕𝗲𝗲𝗿 𝗗𝗮𝘆 (𝗨𝗦) Bock beer is a great reminder that lager history is much bigger than crisp, pale pilsners. The story of lager really took shape in Central Europe, especially Bava...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 17/03/2026
Happy St Patrick's to one and all☘️☘️☘️☘️ Guinness began in 1759 when Arthur Guinness established his brewery at St. James’s Gate in Dublin, originally producing ales before shifting to porter and eventually developing the iconic stout. On this day, we'll learn, what is the chemistry ⚗️ of Guniness 😃
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 14/03/2026
Happy National Pi Day. Pi Day is celebrated on March 14th (3/14) around the world. Pi (Greek letter “π”) is the symbol used in mathematics to represent a constant the ratio of the circumference of a circle to its diameter.
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 07/03/2026
Just wondering if this is more for structural biology or a more for new DMT for megadalton challenges
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 07/03/2026
Would love some leaks on this!
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 09/02/2026
Heard the might be something on direct mass, i.e., CDMS for Orbitrap
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 03/02/2026
Survival rates double when chemo is given in the morning! www.nature.com/articles/s41...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 21/01/2026
Your own publication🎊🎊🎊
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 21/01/2026
2D Gels for Proteoform analysis an older technology with modern application www.linkedin.com/posts/mark-h...
linkedin.com
#proteomics #2de #plantbiology #soybeanresearch #seedproteins #proteoforms #functionalproteomics #plantstressresponse #germination #molecularbiology | Mark Hilliard
🔬** 𝗧𝘄𝗼-𝗱𝗶𝗺𝗲𝗻𝘀𝗶𝗼𝗻𝗮𝗹 𝗘𝗹𝗲𝗰𝘁𝗿𝗼𝗽𝗵𝗼𝗿𝗲𝘀𝗶𝘀-𝗯𝗮𝘀𝗲𝗱 𝗣𝗿𝗼𝘁𝗲𝗼𝗺𝗶𝗰𝘀 𝗥𝗲𝘃𝗲𝗮𝗹𝘀 𝗦𝗼𝘆𝗯𝗲𝗮𝗻 𝗦𝗲𝗲𝗱 𝗛𝘆𝗽𝗼𝗰𝗼𝘁𝘆𝗹 𝗣𝗿𝗼𝘁𝗲𝗼𝗳𝗼𝗿𝗺𝘀 **🔬 🛎 Overview With the growth in intrest in Proteoforms analysis 🧪 But what are Proteoforms ? Proteof...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 20/01/2026
At least they go the mass to charge and not just mass right, small wins 🙈
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 19/12/2025
𝗕𝘂𝗳𝗳𝗲𝗿 𝗖𝗵𝗼𝗶𝗰𝗲 𝗦𝗵𝗮𝗽𝗲𝘀 𝗡𝗮𝘁𝗶𝘃𝗲 𝗠𝗦 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀, 𝗪𝗵𝘆 𝗖𝗵𝗼𝗼𝘀𝗶𝗻𝗴 𝗧𝗵𝗲 𝗥𝗶𝗴𝗵𝘁 𝗕𝘂𝗳𝗳𝗲𝗿 𝗠𝗮𝘁𝘁𝗲𝗿𝘀 !! www.linkedin.com/posts/mark-h...
linkedin.com
#nativems #massspectrometry #proteindynamics #enzymemechanisms #proteinligandinteractions #analyticalchemistry #biophysicalchemistry #methoddevelopment | Mark Hilliard
🌟 🧪 ** 𝗕𝘂𝗳𝗳𝗲𝗿 𝗖𝗵𝗼𝗶𝗰𝗲 𝗦𝗵𝗮𝗽𝗲𝘀 𝗡𝗮𝘁𝗶𝘃𝗲 𝗠𝗦 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀, 𝗪𝗵𝘆 𝗖𝗵𝗼𝗼𝘀𝗶𝗻𝗴 𝗧𝗵𝗲 𝗥𝗶𝗴𝗵𝘁 𝗕𝘂𝗳𝗳𝗲𝗿 𝗠𝗮𝘁𝘁𝗲𝗿𝘀 ** 🧪 🌟 🛎 Overvew: Native mass spectrometry has become a powerful tool for probing protein function, dynamics, and...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 06/12/2025
🤣
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 06/12/2025
Happy Saturday
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 25/11/2025
www.newscientist.com/article/dn87...
newscientist.com
Robot moved by a slime mould's fears
The slime mould - pictured on the screen in the experimental set-up - causes a robot to naturally avoid the light The six-legged hexapod robot is remotely-controlled by slime A bright yellow slime mou...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 22/11/2025
I am old enough to remember the original MudPIT protomics workflows and their impact, this could have very intresting results www.linkedin.com/posts/mark-h...
linkedin.com
#massspec #massspectrometry #nativems #chemistry #protomics #research | Mark Hilliard
🌟🔬 ** 𝗔𝗱𝘃𝗮𝗻𝗰𝗶𝗻𝗴 𝗡𝗮𝘁𝗶𝘃𝗲 𝗦𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗣𝗿𝗼𝘁𝗲𝗼𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝗶𝘃𝗲 𝗠𝘂𝗱𝗣𝗜𝗧 ** 🔬🌟 🛎 Overview: Native structural proteomics seeks to characterize endogenous proteins and protein complexes—capturing their oligomer...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 06/11/2025
Today is International Stout Day. Today, Porter and Stout are essentially the same. Historically, Stout was a stronger version of Porter. Porter got its name from the London porters, (Fellowship/Ticket) who drank it. See the link for more...🍺 www.linkedin.com/posts/mark-h...
linkedin.com
#science #scienceandtechnology #guniness #food #ireland #chemistry #beer #beerindustry #foodscience #infographic | Mark Hilliard
Today is International Stout Day. Today, Porter and Stout are essentially the same. Historically, Stout was a stronger version of Porter. Porter got its name from the London porters, (Fellowship/Tic...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 06/11/2025
Today is National Nacho Day Nachos were first created in 1943, when Chef Ignacio Anaya made a batch for some starved military wives in Mexico, right near Fort Duncan, Texas. See link for more.....🌮🫔 www.linkedin.com/posts/mark-h...
linkedin.com
#science #scienceandtechnology #chemistry #nachos #mexicanfood #mexican #foodscience #food #tacos #foodscienceandtechnology #cheese #dairyindustry #dairy #texas | Mark Hilliard
Today is National Nacho Day Nachos were first created in 1943, when Chef Ignacio Anaya made a batch for some starved military wives in Mexico, right near Fort Duncan, Texas. The original process was...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 30/10/2025
Halloween👻 is only around the corner and Vampires have existed in myth and folklore for hundreds of years and have a well‑established place in popular culture. Just look at the Halloween. www.linkedin.com/posts/mark-h...
linkedin.com
#science #scienceandtechnology #medicalsciences #halloween #vampiree #infographics | Mark Hilliard
Halloween👻 is only around the corner and Vampires have existed in myth and folklore for hundreds of years and have a well‑established place in popular culture. Just look at the Halloween costumes on ...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 29/10/2025
Like cockroachs 🪳, it just keeps coming back..
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 14/10/2025
Oh, I'd say so. They were looking at GMP spaces for this instrument
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 14/10/2025
It, in theory, can run on Waters' empower. I'm not sure it made it to this model Also, tham breakthrough on the nano capillary that looks much more user-friendly
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 04/10/2025
The sad story of HeLa cells and Henrietta Lacks www.linkedin.com/posts/mark-h...
linkedin.com
#science #sciencecommunication #pharma #biomedical #biopharmaceutical #medicalresearch #blackhistory #american #africanamerican #patients | Mark Hilliard
On this day in science, the October 4, 1951 — Henrietta Lacks dies at Johns Hopkins Hospital at the age of 31. Her cells were taken without her knowledge in 1951 (HeLa cells) and became one of the mo...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 04/10/2025
Proteoform Characterization of HIV-1 Broadly Neutralizing Antibody www.linkedin.com/posts/mark-h...
linkedin.com
#massspec #biopharmaceuticals #virology #massspectrometry #chemistry #pharma #hivresearch #immunotherapy #proteomics #biotechnology #broadlyneutralizingantibodies #healthcareinnovation… | Mark Hilliar...
🌟 💉 ** 𝐓𝐡𝐞 𝐏𝐫𝐨𝐦𝐢𝐬𝐞 𝐨𝐟 𝐁𝐫𝐨𝐚𝐝𝐥𝐲 𝐍𝐞𝐮𝐭𝐫𝐚𝐥𝐢𝐳𝐢𝐧𝐠 𝐀𝐧𝐭𝐢𝐛𝐨𝐝𝐢𝐞𝐬 (𝐛𝐍𝐀𝐛𝐬) 𝗙𝗼𝗿 𝐇𝐈𝐕-𝟏 𝐓𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭: 𝗣𝗿𝗼𝘁𝗼𝗳𝗼𝗿𝗺 𝗖𝗵𝗮𝗰𝘁𝗲𝗿𝗶𝘀𝗮𝘁𝗶𝗼𝗻** 💉🌟 🛎 Overview: Broadly neutralizing antibodies (bNAb) are emerging as a game-changer for...
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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 03/10/2025
I am a big fan of the series
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