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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 06/10/2026

What if mass spectrometry finds a protein sequence that isn’t actually encoded in the DNA? That is the intriguing analytical problem raised by a new Nature Cell Biology study on mistranslation in cancer. lnkd.in/p/e4wbzhsM

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 16/08/2026

“Hi, everybody!” 🩺 One of Springfield’s most questionable doctors has a surprisingly real origin. And the story connects The Simpsons, Elvis Presley, prescription medicines and medical ethics. On this day, 16 August 1977, Elvis Presley died at the age of 42.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 12/08/2026

🧀What if we could measure cheese ripening one proteoform at a time? 🔬 Dolman et al. show how intact-protein LC-HRMS can turn αS1-casein hydrolysis during mozzarella ripening into a quantitative kinetic measurement. Link www.linkedin.com/posts/mark-h...

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 13/04/2026

'Today at the X-Omics festival a novel fragmentation technique with Extremely High Energetic photons is presented for the first time. A commercial Q-Exactive was upgraded with this light source and new fragmentation spectra were presented."

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 17/03/2026

Happy St Patrick's to one and all☘️☘️☘️☘️ Guinness began in 1759 when Arthur Guinness established his brewery at St. James’s Gate in Dublin, originally producing ales before shifting to porter and eventually developing the iconic stout. On this day, we'll learn, what is the chemistry ⚗️ of Guniness 😃

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 14/03/2026

Happy National Pi Day. Pi Day is celebrated on March 14th (3/14) around the world. Pi (Greek letter “π”) is the symbol used in mathematics to represent a constant the ratio of the circumference of a circle to its diameter.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 03/02/2026

Survival rates double when chemo is given in the morning! www.nature.com/articles/s41...

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 03/06/2025

Nothing says American Society For Mass Spectrometry (ASMS) more than 7am breakfast vendor seminars! #science #massspec #chemistry #biopharmaceutical #ASMS2025

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 03/06/2025

Antibody Drug Conjugates American Society For Mass Spectrometry (ASMS) 😆😆 ⚗️🧪👨‍🔬👩‍🔬🔬 #ASMS2025 #Chemistry #pharma #ADC #massspec

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 23/05/2025

🔬 ** 𝐀𝐝𝐯𝐚𝐧𝐜𝐞𝐦𝐞𝐧𝐭𝐬 𝐢𝐧 𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡: 𝐏𝐫𝐨𝐭𝐞𝐨𝐟𝐨𝐫𝐦 𝐋𝐚𝐧𝐝𝐬𝐜𝐚𝐩𝐞 𝐨𝐟 𝐓𝐚𝐮 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐇𝐮𝐦𝐚𝐧 𝐁𝐫𝐚𝐢𝐧 ** 🧠 www.linkedin.com/posts/mark-h...

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 08/05/2025

Science Pope Joke from the other place...😀

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 08/05/2025

🌟🔬 **𝐔𝐧𝐥𝐨𝐜𝐤𝐢𝐧𝐠 𝐭𝐡𝐞 𝐌𝐲𝐬𝐭𝐞𝐫𝐢𝐞𝐬 𝐨𝐟 𝐁𝐢𝐨𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐞𝐬 𝐰𝐢𝐭𝐡 𝐗-𝐑𝐚𝐲 𝐌𝐚𝐬𝐬 𝐒𝐩𝐞𝐜𝐭𝐫𝐨𝐦𝐞𝐭𝐫𝐲 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲!** 🌟🔬🌟 King et al publication presents some very intresting and novel work on X-ray mass spectrometry technology for structural biology. 📌 Publication Link lnkd.in/eeWv4ive

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 27/04/2025

🔎 Leblanc et al recent study unveils the complexities of the IgG2 antibody subclass, which is known for its unique disulfide bond connectivity within its hinge region, giving rise to three isoforms: A, A/B, and B. pubs.acs.org/doi/10.1021/...

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 07/04/2025

"You gotta do this one for me, Billy. McGarnagle.....train the processor.."

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 01/02/2025

On this Day in chemistry, Roger Tsien was born. He shares the 2008 Nobel Prize in Chemistry with Osamu Shimomura and Martin Chalfie for their discovery of the green fluorescent protein (GFP).

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 20/11/2024

On this day in science Karl von Frisch was born He shared the 1973 Nobel Prize for Physiology or Medicine. He showed that bees have the ability to recognize different odours and tastes, and discovered their famous "waggle dance" used by bees to communicate among with others in the hive.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 18/11/2024

On this day American scientist George Wald was born Wald was an American biochemist who shared the 1967 Nobel Prize for Physiology or Medicine for “for their discoveries concerning the primary physiological and chemical visual processes in the eye.”

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 15/11/2024

On this day in science Humphry Davy announced the elementary nature of chlorine (Cl). It was previously thought that chlorine was a compound rather than an element, named oxymuriatic acid. Compound Interest Chemistry infographics

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 13/11/2024

On this day in science biochemist Edward A. Doisy was born He shared the Nobel Prize in Physiology or Medicine in 1943 for the isolation and synthesis of vitamin K, which encourages blood clotting and has several applications in medicine.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 12/11/2024

On this day in science Antoine Lavoisier declared water to be a compound, not an element in 1783. The French nobleman performed an experiment using hydrogen (H) and oxygen (O). The product of a reaction between these elements was found to be water, which proved its composition

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 09/11/2024

On this day in science Jack Szostak was born. He received the 2009 Nobel Prize (medicine) for his work on Telomeres Telomeres are structures made from DNA sequences and proteins found at the ends of chromosomes. They cap and protect the end of a chromosome like the end of a shoelace.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 26/10/2024

Today is National Pumpkin 🎃 Day (US) . Pumpkins are a member of the gourd family, which includes cucumbers, honeydew melons, cantaloupe, watermelons and zucchini. Most people don’t realize they are fruits — not vegetables. L.” But what is the chemistry ⚗️ of Pumpkins 🎃

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 27/04/2024

On this day in science Andrew Fire was born Who received the 2006 Nobel Prize in Medicine for his work on RNA interference - gene silencing by double-stranded RNA. RNAi is short for “RNA interference” and it refers to a phenomenon where small pieces of RNA can shut down protein translation

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 09/01/2024

Contaminant Spot Check and Removal Assay (ContamSPOT) for Mass Spectrometry Analysis Here, Smeriglio et al describes a novel method to check for and remove small contamination for peptide maping and proteomic analysis. www.biorxiv.org/content/10.1...

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 05/01/2024

Some really nice work by Pagel et al. demonstrating the power of Ion mobility for O-glycan analysis compared to classical LCMS methodologies , see image www.researchsquare.com/article/rs-3...

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 21/12/2023

Happy Winter Solstice 😀 On the December Solstice, the Northern Hemisphere is at the farthest away from the sun. It’s why the days become shorter, and the nights become longer during this time. December Solstice marks the official beginning of winter.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 04/12/2023

Chemistry advent No 4. What is the chemistry mistletoe The plant’s romantic overtones most likely started with the Celtic Druids of the 1st century A.D. Because mistletoe could blossom even during the frozen winter @compoundchem.bsky.social

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 03/12/2023

Chemistry advent No 3. What is the chemistry of mulled wine. The Victorians seem to have popularised mulled wine in the UK. Charles Dickens writes of a spiced wine called “Smoking Bishop” and later Mrs Beeton describes using spices to “mull wine”. @compoundchem.bsky.social

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 02/12/2023

Chemistry advent No 2. What is the chemistry poinsettia Poinsettia plants are native to Central America, especially an area of southern Mexico known as 'Taxco del Alarcon' where they flower during the winter Poinsettias are great plants to indicate the pH of a liquid.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 29/11/2023

On this day in science the discovery of iodine (I) was announced in 1813 Iodine was first discovered by Barnard Courtois, while extracting potassium and sodium from seaweed ash. When he accidentally added sulfuric acid, a violet colored cloud evolved from the mass. @compoundchem.bsky.social .

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 20/11/2023

Today in National Book Week (US). But what is the chemistry of the aroma of old and new books @compoundchem.bsky.social

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 05/11/2023

On this day in 1955, Doc Brown slips and hits his head and sketches out the Flux Capacitor as a result 😁⏳️

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 05/11/2023

Wang et al describes a very novel approach by in the development of a plastic electrospray probe for direct MS analysis. Its low cost (0.0056 US per probe). An provides high sensitivity and speed of analysis <10 s per sample, including sample loading. lnkd.in/e49_Vqp7

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 04/11/2023

Some very interesting use by Poltash et al. of a novel subunit analysis with native SEC MS to understand the mechanism of aggregation in a multispecific antibody pubs.acs.org/doi/10.1021/...

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 31/10/2023

In keeping with the Halloween 🎃 Theme, What's is the chemistry ⚗️ of Blood. Here is an infographic to explain @compoundchem.bsky.social

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 31/10/2023

In keeping with the Halloween 🎃 Theme. What is the chemistry ⚗️ of fireworks 🎆 Here is an infographic to explain: @compoundchem.bsky.social

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 24/10/2023

Here Karasawa et al describes the sequencing of morpholino antisense oligonucleotides (phosphorodiamidate morpholino oligomers, PMOs) using electron capture dissociation (ECD) mass spectrometry. pubs.acs.org/doi/10.1021/...

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 19/10/2023

Today is International Gin and Tonic Day. The cocktail idea began in India during the 1700’s. Malaria had been roaming around in India and became a problem. George Cleghorn, discovered that quinine, a flavor component of tonic water, could ba used to treat malaria.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 19/10/2023

On this day in science, Craig Mello was born Mello along with Fire, received the 2006 Nobel Prize in Medicine for his work on RNA interference - gene silencing by double-stranded RNA.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 17/10/2023

As Autumn envelopes the northern hemisphere and take hold. We can observe the change in the tree foliage 🍂🍂🍁 But what is the chemistry ⚗️ behind leaf colour change? Here is an infographic to explain how. @compoundchem.bsky.social

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 15/10/2023

On this day in science, the first contraceptive pill was developed 1951 The pill was a steroid hormone, norethindrone, developed by Carl Djerassi and co-workers at Syntex in Mexico City.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 13/10/2023

Today is World egg 🥚 day Jungle fowl were domesticated in India by 3200 B.C.E. Record from China and Egypt show that fowl were domesticated and laying eggs for human consumption! Infographics via @compoundchem.bsky.social

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 12/10/2023

On this day in science the iron lung artificial respirator was put into clinical use in 1928 An iron lung is a cylindrical container, encasing a person’s entire body apart from the head. It regulates air pressure to help a person breathe, and was first used to save the life of a girl with polio

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 11/10/2023

On this day in science the Nobel Prize in Chemistry was awarded to Paul Crutzen, Maria Molina and F. Sherwood Rowland on this day in 1995.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 10/10/2023

On this day in science, Carolyn Bertozzi was born Carolyn Bertozzi took click chemistry to a new level. To map important but elusive biomolecules on the surface of cells – glycans – she developed click reactions that work inside living organisms.

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Mark Oblivious 🧬🧫🔬 @markhill.bsky.social · 10/10/2023

Today is World 🌎 Porridge day. Happy breakfast, everyone The fibre within oats is more soluble than any other grain. This means it keeps you full for long periods of time. Infographic via @compoundchem.bsky.social

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