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Oscar Marín Lab

@marinlab.bsky.social
277 followers 163 following 23 posts

Brain development and childhood disorders laboratory at King's College London

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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
She is! Thanks for the fantastic comic -- it will go on the wall to make company for the one of your paper (and Clems' paper)
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
10/10 Here’s the paper @cellcellpress.bsky.social if you want to dig in www.cell.com/cell/fulltex... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @wellcometrust.bsky.social
cell.com
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
9/10 In sum, our findings reveal a postnatal molecular switch that drives the activity-dependent maturation of parvalbumin interneurons, a critical population for cortical function. Funded by the @wellcometrust.bsky.social
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
8/10 Importantly, this mechanism also allows PV interneurons to regulate their mitochondrial content and function, which may also contribute to their maturation
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
7/10 PGC-1alpha cooperates with ERR-gamma to directly regulate the transcription of many PV-enriched genes. Incidentally, it also seems involved in repressing genes that are typically enriched in other cells, like SST interneurons
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
6/10 How is this achieved? We discovered that PGC-1alpha regulates the expression of most genes that are typically enriched in mature PV interneurons
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
5/10 What are the mechanisms regulating the protracted maturation of cortical interneurons? We found that this process requires neuronal activity and is mediated by the transcriptional modulator PGC-1alpha
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
4/10 Interestingly, while PV interneurons are generated in the embryo, they are late bloomers: in humans, for example, it takes more than two years for PV interneurons to acquire their mature properties
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
3/10 Several unique properties distinguish PV interneurons: They exert a very tight control over the output of pyramidal cells; are fast-spiking, meaning they can fire action potentials at very high frequencies; are covered by perineuronal nets, and have many mitochondria
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
2/10 PV interneurons are a type of inhibitory neuron in the cortex, characterized by their expression of the calcium-binding protein parvalbumin. These neurons play a crucial role in regulating neuronal activity and are involved in #memory, sensory processing, and motor control
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Oscar Marín Lab @marinlab.bsky.social · 16/07/2025
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social @wellcometrust.bsky.social
cell.com
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...
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Reposted by Oscar Marín Lab
Martijn Selten @martijnselten.bsky.social · 15/07/2025
🚨 New Paper Alert! 🚨 I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner. Link below 👇 www.cell.com/cell/fulltex... @cellpress.bsky.social @marinlab.bsky.social
cell.com
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...
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Reposted by Oscar Marín Lab
Centre for Developmental Neurobiology @devneuro.bsky.social · 04/06/2025
We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June @marinlab.bsky.social www.kcl.ac.uk/jobs/116505-...
kcl.ac.uk
Senior Executive Assistant
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Daniel Ibrahim @danielibrahim.bsky.social · 27/05/2025
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...
rdcu.be
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
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Denis Jabaudon @djabaudon.bsky.social · 28/05/2025
Still openings, check it out!
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Hetan Shah @hetanshah.bsky.social · 28/05/2025
On the value of investing in curiosity driven research - which in this case contributed to the personalised gene therapy for a rare disease on.ft.com/45rXI50 @anjahuja.bsky.social
But it also sends a critical message about the value of fundamental and translational
scientific research. The work that led to this breakthrough, using "genetic scissors" to repair a faulty gene, began in laboratories pursuing basic science and was later adapted for therapeutic use. If we are to safeguard the breakthroughs of the future, governments must recognise and protect the pipelines that lead from curiosity-driven investigation to real-world benefit.
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Raticos de Ciencia @raticosdeciencia.bsky.social · 11/05/2025
🎙️[49] ENTENDER EL CEREBRO PARA REGULARLO 👨‍🔬 con #OscarMarínParra @MarinLab Alteraciones durante el desarrollo de nuestro🧠 pueden ser la causa de desordenes psiquiátricos como #autismo, #epilepsia, #bipolaridad o #esquizofrenia #Neurociencias (1/3)
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Oscar Marín Lab @marinlab.bsky.social · 20/05/2025
Yeah, don’t forget the inferior colliculus
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Cedric Boeckx @cedricboeckx.bsky.social · 15/05/2025
Great @nature.com paper on the early stages of human cortical development, led by @qianxuyu.bsky.social from C. Walsh’s lab, in collaboration with @drmingyaoli.bsky.social A wonderful new resource to probe area & layer specification 🧪🧠🧬
nature.com
Spatial transcriptomics reveals human cortical layer and area specification - Nature
Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially res...
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Debby Silver @debbysilver.bsky.social · 14/05/2025
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
nature.com
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
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James Briscoe @jamesbriscoe.bsky.social · 07/05/2025
Meet the 2025 @dev-journal.bsky.social Pathway to Independence (PI) fellows Eight developmental and stem cell biologists transitioning from postdoc to principal investigator journals.biologists.com/dev/pages/pi...
journals.biologists.com
PI Fellows 2025 | Development | The Company of Biologists
PI Fellows 2025 | Development | The Company of Biologists .align{ margin-right: 10px; margin-left: 0px; } .left { float: left; width: 15%; } .right {...
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Oscar Marín Lab @marinlab.bsky.social · 07/05/2025
That’s brilliant — congrats!
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
10/10 Here’s the paper @nature.com if you want to dig in www.nature.com/articles/s41... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @erc.europa.eu
nature.com
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @erc.europa.eu and Rosetrees Trust
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
8/10 Importantly, this mechanism also regulates the connectivity of PV interneurons during learning, for example, in a fear-conditioning paradigm
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
7/10 For PV interneurons, Vgf is the critical gene modulating the plasticity of inhibitory inputs received from other PV interneurons
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
6/10 Incidentally, the Greenberg lab described a few years ago that hippocampal pyramidal cells use Scg2 to modulate the inhibition they receive from PV and CCK interneurons. You can find their paper here www.nature.com/articles/s41...
nature.com
Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network - Nature
Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the role...
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
5/10 How is this achieved? We found that PV interneurons induce the expression of two genes encoding multiple neuropeptides, Scg2 and Vgf, in response to increased activity
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
4/10 Using experimental manipulations, we found that PV interneurons scale the inhibition they receive to maintain stability. When the activity of a PV interneuron increases, it “requests” more inhibitory inputs from other PV+ interneurons, effectively rebalancing its activity
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
3/10 Neuronal activity operates within a tightly controlled range for the optimal functioning of #brain circuits. When synaptic connectivity and network activity are modified, such as when we are learning, compensatory mechanisms are needed to maintain stability
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
2/10 The cortex contains two main classes of neurons: excitatory “go” pyramidal cells and inhibitory “no-go” #interneurons
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Oscar Marín Lab @marinlab.bsky.social · 30/04/2025
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
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Cristian Gutierrez-Ibañez @gallinaciega.bsky.social · 17/04/2025
Our new paper is out. We point out that large brained (and often smart) mammals and birds have evolved very different distribution of neurons numbers in the brain. This means that similar cognitive abilities have evolved in very different brains. www.sciencedirect.com/science/arti...
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Martijn Selten @martijnselten.bsky.social · 26/03/2025
Paper accepted!!! Stay tuned for updates very soon! (Now time for a little celebration)
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