As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Europe PMC is an archive of life sciences journal literature.

Restoring spastin protein levels could be beneficial for patients with hereditary spastic paraplegia. Sardina et al. identify a new druggable pathway regul