Communications Biology - DNMT1 function in cortical PV interneurons modulates cortical network activity, mood disorder‑related behavior, and perineuronal nets

Seminiferous tubules of the testes play an important role in sperm production, but their regulation remain unclear. This study shows that all the cell types that constitute the seminiferous epithelium...

Cichy et al. show that trimethylamine (TMA), a gut microbiome-derived metabolite, activates the receptor TAAR5 in the main olfactory system to regulate aggression and social dominance in male mice. Th...

Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...

Wenn wichtige molekulare Schalter der Genregulation im Gehirn fehlen oder nicht mehr funktionieren, kann das gravierende Folgen für die Entwicklung eines Menschen haben – mit möglichen Folgen wie Schizophrenie, Autismus und Epilepsie. Forschende der RWTH haben nun im Mausmodell untersucht, welche Rolle das Enzym DNMT1 dabei spielt. Die Ergebnisse wurden in der renommierten Fachzeitschrift Nature Communications veröffentlicht.

The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

YouTube video by LastWeekTonight

In most mammals, conspecific chemical cues that drive innate social and sexual behavior are detected by the vomeronasal organ (VNO) and processed in the accessory olfactory bulb (AOB). Chemosensory st...

It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.

The Neural Underpinnings of Waiting Qiang Zheng, Yujing Liu, Yue Huang, Jiaming Cao, Xuanning Wang, and Jianing Yu (see article e1820242025) Waiting is important for action control during motor ta...

Forschende der RWTH Aachen haben gemeinsam mit einem Team aus St. Louis eine Studie veröffentlicht, die neue Wege für die Behandlung von Schwangerschaftskomplikationen eröffnen könnte.

Progesterone and progestins activate Kir7.1 to control uterine excitability, offering insights for preterm birth therapy.

Odors contain complex spatiotemporal information that guide animal behavior, but how this information is processed is not fully understood. This Essay discusses recent advances in mammalian olfactory ...

Human piriform and mediotemporal neurons encode odours, and signal how we perceive, rate and identify scents.