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Marc Spehr

@marcspehr.bsky.social
172 followers 125 following 6 posts
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Reposted by Marc Spehr
PLOS Biology @plosbiology.org · 28/07/2026
Seminiferous tubules of the testes play an important role in #sperm production. This study by @marcspehr.bsky.social &co shows that all cell types in the mouse seminiferous epithelium display unique calcium signaling patterns that are under endocrine control. 🧪#AcademicSky plos.io/3TnAWY9
Confocal microscopy images of a single seminiferous tubule section from an AHM-Cre x Ai14D male mouse depict (i) Sertoli cells that express a fluorescent protein (tdTomato; red) as well as all (ii) cell nuclei stained with DRAQ5 (cyan). Individual Sertoli cells support numerous germ cells. At the apical epithelial surface, nuclei become elongated and condensed as germ cells mature.
Image created by Jerome Schröer, Lina Kenzler, Stefanie Kurth, and Marc Spehr. CC-BY license.
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Marc Spehr @marcspehr.bsky.social · 28/07/2026
Beginning to understand the physiology of spermatogenesis is really fun and super fascinating. A big thank you and congrats to everyone involved in this study. It took us a while, but it was worth it. P.S.: check out the supplemental movies.
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Reposted by Marc Spehr
PLOS Biology @plosbiology.org · 28/07/2026
Seminiferous tubules of the testes play an important role in #sperm production. This study by @marcspehr.bsky.social &co shows that all cell types in the mouse seminiferous epithelium display unique calcium signaling patterns that are under endocrine control. 🧪#AcademicSky plos.io/3TnAWY9
Confocal microscopy images of a single seminiferous tubule section from an AHM-Cre x Ai14D male mouse depict (i) Sertoli cells that express a fluorescent protein (tdTomato; red) as well as all (ii) cell nuclei stained with DRAQ5 (cyan). Individual Sertoli cells support numerous germ cells. At the apical epithelial surface, nuclei become elongated and condensed as germ cells mature.
Image created by Jerome Schröer, Lina Kenzler, Stefanie Kurth, and Marc Spehr. CC-BY license.
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Reposted by Marc Spehr
Justine Fischoeder @justinefischoeder.bsky.social · 25/07/2026
I am happy to announce my PhD project on cell communication in the mouse testis has finally been published! I have really enjoyed working on this during my time at the Spehr Lab and I am very grateful to everyone who contributed to this study! journals.plos.org/plosbiology/...
journals.plos.org
Cell type-specific Ca2+ signals govern mouse seminiferous tubule physiology
Seminiferous tubules of the testes play an important role in sperm production, but their regulation remain unclear. This study shows that all the cell types that constitute the seminiferous epithelium...
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Reposted by Marc Spehr
Ivan Manzini @xenofrog.bsky.social · 07/07/2026
🐸 Postdoc Position (m/f/d) in Neurobiology! The project focuses on how smell shapes feeding behavior in poison frogs and is conducted in collaboration with Prof. Jennifer Stynoski (Costa Rica). 🌎🌿 . For more information and to apply, please use the link below. www.uni-giessen.de/de/ueber-uns...
uni-giessen.de
Research Associate / Postdoctoral Researcher (m/f/d) “Olfactory Control of Behavior in Amphibians”
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Reposted by Marc Spehr
Bozza Lab @neuroboz.bsky.social · 30/03/2026
Happy to share the latest from the lab! A microbiome-generated metabolite affects male-male aggression and social dominance in mice via the main olfactory system. Gut-Nose-Behavior. www.cell.com/current-biol...
cell.com
A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice
Cichy et al. show that trimethylamine (TMA), a gut microbiome-derived metabolite, activates the receptor TAAR5 in the main olfactory system to regulate aggression and social dominance in male mice. Th...
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Reposted by Marc Spehr
fkne-scholars.bsky.social @fkne-scholars.bsky.social · 04/02/2026
Send us nominations for the FKNE Mentoring Prize 2026!The award will be presented at FENS Forum 2026 in Barcelona to a scientist who has demontrated leadership in fostering the careers of neuroscientists. Deadline: 15 February 2026 2cm.es/1gh-m
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Reposted by Marc Spehr
iBehave @ibehave.bsky.social · 06/01/2026
📢 iBehave Seminar Series 2026! 🎙 Prof. Dr. Veronica Egger, @uniregensburg.bsky.social 🧠 “Rhythms in the olfactory bulb: From neuronal network oscillations to heartbeat interoception" 📅 Jan 12, 2026 • 10:30 Host: Gaia Tavosanis @rwth.bsky.social 💻 Zoom link via iBehave@uni-bonn.de #ibehave
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Reposted by Marc Spehr
Tobias Ackels @tobiasackels.bsky.social · 11/12/2025
PhD position in systems neuroscience! Excited to start a new DFG-funded project together with @obarnstedt.bsky.social to study olfactory–spatial coding in CA1. 🔬 Dual-colour miniscope Ca2+ imaging 🐭 Freely moving behaviour & optogenetics ⏳ Start: April 2026 | Deadline: 31.01.2026 More info below ⬇️
The project studies how the hippocampal CA1 integrates olfactory and spatial information for goal-directed navigation. The position is a 3-year DFG-funded PhD (TV-L E13, 65%) starting April 2026, jointly supervised by Prof. Tobias Ackels at University Hospital Bonn and Dr. Oliver Barnstedt at the European Neuroscience Institute Göttingen. The project uses dual-colour miniscope calcium imaging, optogenetics, and behavioural experiments in freely moving mice. Application deadline is 31 January 2026, with applications sent by email.
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Reposted by Marc Spehr
Geraldine Zimmer-Bensch @zimmer-bensch.bsky.social · 20/10/2025
What if the DNA methylation enzyme DNMT1 isn’t just about DNA? Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking. A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
biorxiv.org
A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation
Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...
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Reposted by Marc Spehr
Ivan Manzini @xenofrog.bsky.social · 22/08/2025
🚨 We are looking for 2 PhD students! 🧠🐸👃 Join the Manzini Lab @jlugiessen.bsky.social to explore the olfactory system in #aquatic #vertebrates. We mainly use #amphibians, combining: 🔬 Imaging 👩‍🔬 Cell biology 🐝 Behavior 👉 bit.ly/neurophd 🌍 bit.ly/manzinilab Please share! #PhD #neuroscience #job
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Geraldine Zimmer-Bensch @zimmer-bensch.bsky.social · 18/08/2025
🌍 Open Call! RWTH Aachen University invites postdocs from outside the EU to apply for the “Port to Europe” Fellowship (24 months funding, all disciplines). Start your research journey at one of Europe’s top universities! 🚀 Deadline: Oct 5, 2025. 👉https://rwth-aachen.de/go/id/botjje/lidx/1
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RWTH Aachen University @rwth.bsky.social · 29/07/2025
Studie von RWTH-Professorin und ihrem Team in der Fachzeitschrift Nature Communications veröffentlicht 📃💡: Die Forschenden untersuchen die Bedeutung des Enzyms DNMT1 für die Entstehung von Schizophrenie, Autismus und Epilepsie. ➡️ Mehr Infos: www.rwth-aachen.de/go/id/bouvms...
rwth-aachen.de
Studie liefert Hinweise auf Ursachen neuropsychiatrischer Erkrankungen | RWTH Aachen University | DE
Wenn wichtige molekulare Schalter der Genregulation im Gehirn fehlen oder nicht mehr funktionieren, kann das gravierende Folgen für die Entwicklung eines Menschen haben – mit möglichen Folgen wie Schizophrenie, Autismus und Epilepsie. Forschende der RWTH haben nun im Mausmodell untersucht, welche Rolle das Enzym DNMT1 dabei spielt. Die Ergebnisse wurden in der renommierten Fachzeitschrift Nature Communications veröffentlicht.
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Jason Shepherd @jasonsynaptic.bsky.social · 12/07/2025
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...
genengnews.com
Why We Still Need Animal Research in a World of AI and Organoids
The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.
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Julius-Maximilians-Universität Würzburg @uni-wuerzburg.de · 21/05/2025
Wir begrüßen Professorin @silkesachse.bsky.social‬ als neue Leiterin des Lehrstuhls für #Neurobiologie und #Genetik! Sie kommt aus Jena zu uns (@mpi-ce.bsky.social) und erforscht den Geruchssinn von #Insekten. ➡️ www.uni-wuerzburg.de/aktuelles/ei...
Die neue Würzburger Professorin Silke Sachse. (Foto: Nives Kramberger)
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Reposted by Marc Spehr
Tobias Ackels @tobiasackels.bsky.social · 18/05/2025
🚨 Preprint alert! 🚨 Can mice estimate the distance to an odour source? New work led by Cristina Marin and colleagues, jointly supervised by @andreas-t-schaefer.bsky.social at the @crick.ac.uk and myself. Spoiler alert: Yes, they can! Read the paper here: bit.ly/43A9tF9 Short 🧵 below
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Marc Spehr @marcspehr.bsky.social · 28/04/2025
Highly recommended: youtu.be/8H34jcpEsFs?...
youtu.be
RFK Jr. & HHS: Last Week Tonight with John Oliver (HBO)
YouTube video by LastWeekTonight
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Marc Spehr @marcspehr.bsky.social · 22/04/2025
P.S.: If you cannot get enough of this, stop by at our poster at AChemS 2025 on Thursday morning.
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Marc Spehr @marcspehr.bsky.social · 22/04/2025
www.jneurosci.org/content/45/1... Excited to see this out (now in print). A fantastic collaboration by former student Rudolf Degen and current PhD student Victoria Switacz, who did an amazing job closing the deal on this one. Give it a read if you like, but beware - it's nerdy ephys at its best.
jneurosci.org
Ca2+-Activated Ion Channels Exert Opposite Effects in Different Signaling Compartments of Vomeronasal Sensory Neurons
In most mammals, conspecific chemical cues that drive innate social and sexual behavior are detected by the vomeronasal organ (VNO) and processed in the accessory olfactory bulb (AOB). Chemosensory st...
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Reposted by Marc Spehr
The Transmitter @thetransmitter.bsky.social · 16/04/2025
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/olfaction/sm...
thetransmitter.org
Smell studies often use unnaturally high odor concentrations, analysis reveals
It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.
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Reposted by Marc Spehr
SfN Journals @sfnjournals.bsky.social · 16/04/2025
This Week in The Journal #JNeurosci | The Neural Underpinnings of Waiting; Behavioral Outcomes from Neurofibromin Deficiency www.jneurosci.org/content/45/1...
jneurosci.org
This Week in The Journal
The Neural Underpinnings of Waiting Qiang Zheng, Yujing Liu, Yue Huang, Jiaming Cao, Xuanning Wang, and Jianing Yu (see article e1820242025) Waiting is important for action control during motor ta...
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Reposted by Marc Spehr
Healthcare in Europe (DE) @health-europe-de.bsky.social · 01/04/2025
Vorzeitige #Wehen und #Präeklampsie können bei einer #Schwangerschaft die #Gesundheit von Mutter und Baby gefährden. Forscher um @marcspehr.bsky.social von der @rwth.bsky.social und @physiologyiscool.bsky.social von @washumedicine.bsky.social zeigen einen zentralen Auslöser dieser Komplikationen.
dlvr.it
Neue Ansätze zur Behandlung von Schwangerschaftskomplikationen
Forschende der RWTH Aachen haben gemeinsam mit einem Team aus St. Louis eine Studie veröffentlicht, die neue Wege für die Behandlung von Schwangerschaftskomplikationen eröffnen könnte.
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Marc Spehr @marcspehr.bsky.social · 06/03/2025
A scientific excursion for us, and a fun collaboration with Polina Lishko and her team. In this new study, led on our end by Lina Kenzler and Jerome Schrőer, we address a molecular mechanism that controls uterine contractions in mice and humans. Enjoy the read. www.science.org/doi/10.1126/...
science.org
Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function
Progesterone and progestins activate Kir7.1 to control uterine excitability, offering insights for preterm birth therapy.
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Federation of European Neuroscience Societies - FENS @fens.org · 05/03/2025
📣 Science matters! #FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬 🔗 Read the full statement: loom.ly/cn7vJR4 #sciencematters #standupforscience #sciencenotsilence #scienceforall
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fkne-scholars.bsky.social @fkne-scholars.bsky.social · 17/02/2025
2024 marked the 10-year anniversary of the FENS-Kavli Network of Excellence. We warmly invite you to explore the 10-Year Report, showcasing its impact on science, mentoring, outreach, advocacy, and personal achievements. @fens.org @kavlifoundation.bsky.social fenskavlinetwork.org/fkne-10-year...
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Ben Saunders @bensaunders.bsky.social · 12/02/2025
With the huge challenges facing scientists, I call on peer reviewers to reflect on their role as gatekeepers to trainee career development and scientific progress. You can maintain high standards for rigor while being kind and not demanding an extra year of studies for every paper revision.
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Tobias Ackels @tobiasackels.bsky.social · 28/01/2025
I am deeply grateful for this award, which not only recognizes my work but also reflects the invaluable contributions of my team, mentors, and supporters! It inspires me to continue working with my lab to deepen our understanding of how we perceive and interpret our environment.
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Association for Chemoreception Sciences (AChemS) @achems.bsky.social · 13/01/2025
⏰ Last chance! Today is the final day to submit your #AChemS2025 abstract! Submit now: achems.org/2025/abstrac...
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Björn Brembs @brembs.mastodon.social.ap.brid.gy · 07/01/2025
We are hiring! We are looking for two PhD students interested in the regulation of habit formation. Habits are useful to decrease cognitive load, but carry the risk of becoming stereotyped and hard to control - it’s hard to shake a bad habit. The fruit fly Drosophila also forms habits and we […]
mastodon.social
Original post on mastodon.social
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Reposted by Marc Spehr
iBehave @ibehave.bsky.social · 02/01/2025
🎉✨ Happy New Year ! ✨🎉 Wishing you a year filled with inspiration, discovery, & happiness! Here's to making 2025 remarkable together. #happynewyear #thanks #community @wisocologne.bsky.social @unibonn.bsky.social @dzne.science @mpinb.mpg.de @fz_juelich @rwth.bsky.social @UniklinikBonn @DLR-PT
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Dan Goodman @neural-reckoning.org · 18/12/2024
There's a movement in neuroscience suggesting we should be pursuing bigger bets with larger teams. I think there's a case for doing a bit of this, but I think it's a bad idea to prioritise it for two reasons, and a good case for saying we should be moving in the exact opposite direction. 🧠🧪
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Ardem Patapoutian @ardemp.bskyverified.social · 09/12/2024
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...
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Julian Meeks @meeksandmilds.bsky.social · 03/12/2024
On Giving Tuesday, please consider making a donation to a nonprofit like AChemS (@achems.bsky.social) that supports academic scientific research, which is essential for building new knowledge about how our bodies work!
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Tobias Ackels @tobiasackels.bsky.social · 22/11/2024
Check out our new review in PLoS Biology on how dynamic odour information can help mammals to navigate through their environment. Led by the fantastic Anantu Sunil & Olivia Pedroncini, this also marks my first last author publication from the University of Bonn! journals.plos.org/plosbiology/...
journals.plos.org
How do mammals convert dynamic odor information into neural maps for landscape navigation?
Odors contain complex spatiotemporal information that guide animal behavior, but how this information is processed is not fully understood. This Essay discusses recent advances in mammalian olfactory ...
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iBehave @ibehave.bsky.social · 12/11/2024
🔊Major Breakthrough Researchers from @UniklinikBonn @unibonn.bsky.social @rwth.bsky.social reveal how single neurons respond to smells, images & words! This study in @natureportfolio.bsky.social bridges the gap between animal & human olfactory research!👃 📖 www.nature.com/articles/s41...
nature.com
Single-neuron representations of odours in the human brain - Nature
Human piriform and mediotemporal neurons encode odours, and signal how we perceive, rate and identify scents.
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The Transmitter @thetransmitter.bsky.social · 09/10/2024
Unlike the primary sensory brain areas that process sights and sounds, the one that decodes scents also responds to other stimuli, such as images and words associated with an odor, according to a study published today in Nature. By @avaskham.bsky.social www.thetransmitter.org/sensory-syst...
thetransmitter.org
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