iiinova — where your digital self keeps evolving

Reposted by Marc Mansour

Carl Zimmer @carlzimmer.com · 28/01/2026

I wrote today about AlphaGenome, Google DeepMind's AI for DNA. It's powerful, experts told me, but it won't solve the mysteries of the genome overnight. Gift link: nyti.ms/4k5NFIl

nyti.ms

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Reposted by Marc Mansour

CeMM @cemm.oeaw.ac.at · 28/11/2025

🧬 New strategy to fight #AML: A study led by @floriangrebien.bsky.social & team at Vetmeduni, @stanna-ccri.bsky.social & CeMM identified the protein SPOP as a direct regulator of the stability of NUP98 fusion oncoproteins, a potential target for new therapies. ➡️ bit.ly/3M2RfWz 📄 bit.ly/4omtZ3x

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Reposted by Marc Mansour

Nick Jones @nickjonesimmuno.bsky.social · 21/10/2025

Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine. www.sciencedirect.com/science/arti...

sciencedirect.com

Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

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Reposted by Marc Mansour

Arnaud Krebs @arnaudkr.bsky.social · 18/08/2025

This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

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Reposted by Marc Mansour

Jennifer Trowbridge @trowbridgelab.bsky.social · 16/04/2025

Congrats to Kira Young who spearheaded this work & all contributing authors. This was a fun (and long!) collaboration with @marcmansour.bsky.social, @challenlab.bsky.social, @ericpietras.bsky.social, Kelsey Fisher-Wellman, @keisukeito-lab.bsky.social & Steven Chan

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Marc Mansour @marcmansour.bsky.social · 09/01/2025

Thanks Sunniyat - great to be part of the Bluesky community- like a breath of fresh air !

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Marc Mansour @marcmansour.bsky.social · 08/01/2025

This is fantastic mechanistic work Dorien, Ruud and team! Congrats

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Reposted by Marc Mansour

Sunniyat Rahman @minimolecule.bsky.social · 10/12/2024

For my new followers! Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in @bloodjournal.bsky.social, we’ve discovered a novel mechanism of oncogene activation whereby focal deletion of a ‘promoter tether’ leads to aberrant expression of IRX3 in T-ALL.👇

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