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Marc Liesa

@marcliesa.bsky.social
593 followers 542 following 45 posts

Director, Institut de Biologia Molecular de Barcelona, @csic.es. Group Leader: Mitochondria, redox and metabolic diseases. Previous Assoc. Prof at @uofcalifornia.bsky.social LA, Post Doc at @bostonu.bsky.social & PhD @ub.edu. t.co/bvx8gnppAW

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Reposted by Marc Liesa
The EMBO Journal @embojournal.org · 06/07/2026
Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets - facilitating lipolysis during thermogenesis Israel Sekler, Orian Shirihai and collaborators link.springer.com/article/10.1...
link.springer.com
Mitochondrial calcium regulates lipid metabolism by modulating tethering of mitochondria to lipid droplets - The EMBO Journal
Adrenergic stimulation of brown adipocytes induces a robust detachment of mitochondria from lipid droplets (LD), which is followed by lipolysis and lipid catabolism. However, the signals inducing mito...
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Reposted by Marc Liesa
caixaresearch.bsky.social @caixaresearch.bsky.social · 26/06/2026
1/ We now know the selected projects from the 2026 Health Research Call! A total of 32 projects from Spain and Portugal that will drive new solutions for the health of the future. 👇🧵 tinyurl.com/5n6tyat8
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Reposted by Marc Liesa
Keri Backus @keribackus.bsky.social · 28/04/2026
Super excited that our SEE-CITE photoaffinity labeling method is now out in @natchem.nature.com rdcu.be/ffBSC. Here we introduce a custom silyl ether cleavable linker between a diazirine photocrosslinker handle and molecules of interest to streamline site-of-labeling analysis for PAL chemoproteomics
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Reposted by Marc Liesa
Nature Metabolism @natmetabolism.nature.com · 30/03/2026
dlvr.it
The expanding role of mitochondria–lipid droplet contacts in liver and their disruption by MASLD
Nature Metabolism, Published online: 23 March 2026; doi:10.1038/s42255-026-01483-2By determining the organellar topology and proteome of fat-oxidizing and fat-synthesizing hepatocytes, Kang et al. show that perilipin 5-mediated mitochondria–lipid droplet contacts facilitate the expansion of lipid droplets in both populations and are impaired in early metabolic dysfunction-associated steatotic liver disease (MASLD).
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Marc Liesa @marcliesa.bsky.social · 24/03/2026
Congrats @PoratShliomLab for this fantastic paper and thank you for your nice words about the comment. We are very happy you liked it!
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Marc Liesa @marcliesa.bsky.social · 23/03/2026
Excited to share this commentary on the fantastic paper out today @natmetabolism.nature.com by Porat-Shliom and colleagues on the role of mitochondria and lipid droplets contacts in the liver. rdcu.be/e9uYa @ibmb-csic.bsky.social @csic.es
rdcu.be
The expanding role of mitochondria–lipid droplet contacts in liver and their disruption by MASLD
Nature Metabolism - By determining the organellar topology and proteome of fat-oxidizing and fat-synthesizing hepatocytes, Kang et al. show that perilipin 5-mediated mitochondria–lipid...
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Reposted by Marc Liesa
Óscar Tovar @oscartovar.bsky.social · 17/11/2025
Extremely happy to see this out in @embojournal.org! Here we provide a guide on how to accurately determine mitochondrial membrane potential. Thanks to @marcliesa.bsky.social for the opportunity and to everyone involved! We hope you find it useful! @ibmb-csic.bsky.social
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Marc Liesa @marcliesa.bsky.social · 17/11/2025
Very happy with this comment out today! It was a fantastic teamwork effort, with invaluable input from the editor @embojournal.org and the reviewers. Thanks a lot to all involved! @csic.es @ibmb-csic.bsky.social
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Reposted by Marc Liesa
The EMBO Journal @embojournal.org · 17/11/2025
Measuring mitochondrial membrane potential @marcliesa.bsky.social , Guillermo Martínez-Corrales et al @ibmb-csic.bsky.social comment on common misinterpretation of mitochondrial membrane potential measurements & suggest guidelines for accurate determination in cells www.embopress.org/doi/full/10....
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Reposted by Marc Liesa
Journal of Clinical Investigation @jci.org · 19/09/2025
Blocking extracellular glycine uptake mediated by GlyT1 mitigates protoporphyria @marcliesa.bsky.social provides a Commentary on Ducamp et al. (buff.ly/W67oexo) buff.ly/9TuVOy3
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Marc Liesa @marcliesa.bsky.social · 18/09/2025
Very cool. I always wondered why BAT was lipogenic with FASN activity. Congrats!
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Marc Liesa @marcliesa.bsky.social · 17/09/2025
Thank you @jclinical-invest.bsky.social for inviting me to write a commentary about the original study published yesterday by Ducamp and colleagues, which shows a metabolic strategy to treat protoporphyrias. Commentary: www.jci.org/articles/vie.... Article: www.jci.org/articles/vie....
jci.org
JCI - Blocking extracellular glycine uptake mediated by GlyT1 mitigates protoporphyria
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Reposted by Marc Liesa
ibmb-csic.bsky.social @ibmb-csic.bsky.social · 04/09/2025
Irene Hernando-Herráez, a researcher at the IBMB-CSIC, has been awarded a Starting Grant from the European Research Council (@erc.europa.eu), funded with €1.5 million. These prestigious grants support young scientists leading outstanding research projects. #ERCStG
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Reposted by Marc Liesa
Minczuk Lab @mitogene.bsky.social · 12/04/2025
🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!
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Reposted by Marc Liesa
ABC2025 @abcmeeting.bsky.social · 07/03/2025
We had an amazing time with the ABC family and already miss you all! Can’t wait to hear your exciting talks, have great discussions, and hit the slopes of the Alps again. #ABC2025 See you next time!🗻⛷️🚠🧬🧫🧪💙
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Reposted by Marc Liesa
ABC2025 @abcmeeting.bsky.social · 01/03/2025
Maria Zoghbi says she's in "ABC transporter heaven" at #ABC2025 🥰 A closer look at ABCB10 transporter dynamics may well keep you on cloud number nine... ☁️⭐️
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Reposted by Marc Liesa
ABC2025 @abcmeeting.bsky.social · 28/02/2025
Moving into mitochondria with Marc Liesa! ABCB10, heme and redox stress: Some projects are literally a blood.bath... maybe sounds familiar to some other researchers out there? 😅🩸
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Marc Liesa @marcliesa.bsky.social · 17/02/2025
Makes sense.
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Marc Liesa @marcliesa.bsky.social · 17/02/2025
My mistake. Got conditioned by the previous post about the panel scheduled for the same day as this one, but being delayed by absence of posting. It seems that posting dates can vary significantly between study sections then.
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Marc Liesa @marcliesa.bsky.social · 17/02/2025
This one was posted today and the meeting is tomorrow. Maybe postings are delayed?
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Reposted by Marc Liesa
Enric I. Canela @enriccanela.bsky.social · 29/12/2024
Educació i innovació www.elpuntavui.cat/opinio/artic... @epons.bsky.social @jordivitria.bsky.social @pcb-ub.bsky.social @abadal.bsky.social @aristides-lopez.bsky.social @maricarmenb.bsky.social @kutandalkim.bsky.social @gaiaub.bsky.social @vcliments.bsky.social @marcliesa.bsky.social
elpuntavui.cat
Educació i innovació
Ha començat una nova legislatura. Hi ha un nou govern a Catalunya i s'esperen els nous equips dels departaments. Al mes d'agost i sense conèixer els equips que acompanyaran els consellers no es poden....
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Marc Liesa @marcliesa.bsky.social · 13/12/2024
The data of PLIN5 regulation and its mutants is so cool too.
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Reposted by Marc Liesa
@PoratShliomLab @poratshliomlab.bsky.social · 12/12/2024
Preprint alert!! How zonated hepatocytes adapt to changes in lipid influx due to fasting or a Western diet (WD). We developed a microscopy-based phenotyping method called single-cell phenomics (scPhenomics) to measure the features of mitochondria and lipid droplets (LDs).
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Marc Liesa @marcliesa.bsky.social · 13/12/2024
Fantastic work! Congratulations!!
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Marc Liesa @marcliesa.bsky.social · 10/12/2024
Congrats!!
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Reposted by Marc Liesa
ABC2025 @abcmeeting.bsky.social · 02/12/2024
Join your fellow #ABC friends in the lecture hall and on the slopes for ABC2025 in Innsbruck Feb 27-Mar03! Register abc2025meeting.org and see our invited speakers´list below! See you in Innsbruck!🧬⛰️🏂🧪
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Reposted by Marc Liesa
Ewa Bomba-Warczak @ebomba.bsky.social · 02/12/2024
Last @mitotalks.bsky.social by @marcliesa.bsky.social See mitotalks.org for a link to join
mitotalks.org
MITO talks online seminar series | mitochondria
MITOtalks: Online Seminar Series Focusing on Mitochondria
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Reposted by Marc Liesa
Agingdoc⭐David Barzilai🔔MD PhD, MS, MBA, DipABLM @agingdoc.bsky.social · 26/11/2024
SHADES OF BLUE Blue zones, supposed havens of longevity, have become a global brand. But skeptics think they rest on shaky science www.science.org/content/arti...
science.org
Do ‘blue zones,’ supposed havens of longevity, rest on shaky science?
Critics say extraordinary life spans reflect faulty record keeping, not healthy lifestyles
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Reposted by Marc Liesa
Heiko Lickert @heikolickert.bsky.social · 25/11/2024
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”. doi.org/10.1038/s422... A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
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Reposted by Marc Liesa
Marc Somssich @somssich.bsky.social · 20/05/2024
Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇
A profile picture of Douglas Prasher from Martin Chalfie's Nobel Lecture
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Marc Liesa @marcliesa.bsky.social · 20/11/2024
www.sciencedirect.com/science/arti...
sciencedirect.com
The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis
Acute liver failure caused by alcoholic hepatitis (AH) is only effectively treated with liver transplantation. Livers of patients with AH show a uniqu…
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Reposted by Marc Liesa
Tim Stearns @stearnslab.bsky.social · 17/11/2024
“The product of your education is not your thesis, it’s yourself“ @annarogers.bsky.social on why not to rely on LLM AI to write for you in graduate school. hackingsemantics.xyz/2024/writing/
hackingsemantics.xyz
On AI-assisted writing in graduate school
What is the proper role of AI ‘assistance’ in graduate student writing? It depends on what you mean by ‘graduate’.
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Marc Liesa @marcliesa.bsky.social · 01/10/2024
2 days left to register and present a poster to the 10th MetNet meeting on mitochondria and metabolism. The final program with the selected short talks is now available. Looking forward to see you! @EMBO @IBMB_CSIC @IBUB_UB @IRBBarcelona @ciberdem @idibaps @VHIR_ @UABBarcelona
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Marc Liesa @marcliesa.bsky.social · 07/09/2024
Deadline for registration to the Mitochondria and Metabolism meeting October 24-25th in Barcelona is soon! Sept 15 for oral presentation and Oct 3rd to secure your spot! With an @EMBO keynote lecture! Registration link:
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Marc Liesa @marcliesa.bsky.social · 03/05/2024
Do not miss the most special Mitochondria Meeting in Barcelona, Oct 24-25th, with @OrianShirihai @GenoxphosLab @SWculek @FormentiniLaura @AlbertPol10 @QuintanaLab @mitodynamics @avlecvie @LabScorrano @AntonioZorzano ..., incl. short talks & posters. Registration & Program👇 .
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Marc Liesa @marcliesa.bsky.social · 07/02/2024
Highly motivated after the kick-off meeting with @CSIC colleagues and president @delPinoE for the preparation of a Science 4 Policy report about Metabolic Diseases, together with @DiabetesLabIBGM, María Monsalve, Angela M Valverde, María Angeles Martín and Yolanda Sanz.
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Marc Liesa @marcliesa.bsky.social · 25/01/2024
Very excited with our new study just published in Redox Biology! We show that mitochondrial redox in hepatocytes determines the pro-inflammatory capacity of infiltrated neutrophils in alcohol-induced hepatitis.
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Marc Liesa @marcliesa.bsky.social · 06/12/2023
It is out! Here we describe a new method to isolate peridroplet mitochondria (PDM) from white adipose tissue (WAT), revealing unique functional characteristics in WAT PDM determined by lipid droplet size.
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Marc Liesa @marcliesa.bsky.social · 30/08/2023
Happy to share our manuscript in its final form! Fantastic collaboration with Bantam Pharma. Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1 | American Association for Cancer Research
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Marc Liesa @marcliesa.bsky.social · 13/04/2023
Very excited to see where biliverdin binds to ABCB10 for the first time! Cryo-EM structures of mitochondrial ABC transporter ABCB10 in apo and biliverdin-bound form ⁦@NatureComms⁩ ⁦@mikeshum22⁩
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Marc Liesa @marcliesa.bsky.social · 13/03/2023
Very excited to share our new study @embojournal with @OrianShirihai⁩ and led by ⁦@R_AcinPerez⁩ and ⁦@CrisBenincaPhD⁩. We find that inhibiting mitochondrial complex V reverse activity restores energy homeostasis in mito pathologies.
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Marc Liesa @marcliesa.bsky.social · 06/12/2022
Congratulations to Joe and Andrew. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
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Marc Liesa @marcliesa.bsky.social · 06/12/2022
Congratulations to Manu and Susana. ISG15 Is a Novel Regulator of Lipid Metabolism during Vaccinia Virus Infection | Microbiology Spectrum
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Marc Liesa @marcliesa.bsky.social · 06/08/2022
Very happy to share our latest collaboration with Janssen: The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR ⁦@OrianShirihai⁩ ⁦@JNgo1412⁩
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Marc Liesa @marcliesa.bsky.social · 05/06/2022
Today @JNgo1412 is presenting two posters from our lab at #ADA2022 showing how mitochondrial dynamics regulate fat utilization and counteract NASH (12-13h)⁦.⁩
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Marc Liesa @marcliesa.bsky.social · 04/06/2022
Very happy with today’s presentations and the engaging audience in the Fuel Energetics in Islet Hormone. Looking forward to the afternoon sessions! #ADA2022 @AmDiabetesAssn
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Marc Liesa @marcliesa.bsky.social · 12/05/2022
If you are attending the 82nd Scientific Sessions of the American Diabetes Association (ADA), come to see my talk on Saturday June 4th 2022 in New Orleans! @ADA_Pubs @AmDiabetesAssn
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Marc Liesa @marcliesa.bsky.social · 22/04/2022
Had a great time reading the paper and writing the news and views. Congrats to @tom_mcphagy lab! The EMBO Journal | The goodies of chelated fat: iron‐regulated lipid droplet biogenesis precedes and preserves mitophagy
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