We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals)....

MASC: The Macrocyclic and Supramolecular Chemistry Interest Group 2025 MASC Prize Calls 2025 RSC MASC Group PhD Thesis Award given in memory of John Fossey: The RSC MASC Group P…

vMASC: Expression of interest to volunteer for the vMASC committee The organising committee of the virtual Macrocyclic and Supramolecular Chemistry We are inviting members of the vMASC community to…

Nature Nanotechnology - An abiotic information ratchet mechanism increases selectivity for the correct DNA duplex from 2:1 at equilibrium to 6:1 under energy-dissipating conditions.

A unique class of tubular polymer structures that are soluble in apolar organic solvents but are endowed with polar pores has been created through the rational design of the monomer units, which self...

Inspired by the extraordinary attributes displayed by nanotubes in Nature, the creation of self-assembled nano-sized hollow tubes is an area of significant and growing interest given its potential app...

An efficient synthetic protocol for the synthesis of a library of unprecedented resorcin[4]arene-based water-soluble molecular containers is reported here. Key to this approach is the tetra-iodo deriv...

The use of water as a solvent to facilitate supramolecular self-assembly and polymerization is well-documented; however, it is rare that water acts as a monomer that undergoes polymerization. We repor...

The use of water as a solvent to facilitate supramolecular self-assembly and polymerization is well-documented; however, it is rare that water acts as a monomer that undergoes polymerization. We repor...

Subtle structural variations among fatty acids significantly influence their biological roles and health effects. However, molecular recognition of their long, flexible, and chemically inert hydrocarbon chains remains a challenge. Inspired by natural fatty acid-binding proteins (FABPs), we designed and synthesized nanotubular metallo-cavitands, termed metal–organic pillars, through the coordination-driven assembly of pillararene-derived ligands with Ag(I) salts. These biomimetic hosts feature continuous interior channels exceeding 2.6 nm, selectively binding long-chain fatty acids through precise size and shape complementarity. Saturated and trans fatty acids, with linear conformations, are effectively encapsulated and stabilized by C–H···π and van der Waals interactions. In contrast, coiled cis-polyunsaturated fatty acids, such as docosahexaenoic acid (DHA), cannot be accommodated due to structural incompatibility. This work highlights the ability of artificial receptors to emulate the recognition capabilities of natural proteins, enabling the targeting of “bad” fatty acids associated with adverse health effects.

Proteins dynamically adjust their conformations to interact with their ligands through binding sites that accommodate either amphiphilic or hydrophilic substrates, but most synthetic receptors are des...

Nitroacetic acid, the most active activated carboxylic acid (ACA) employed so far, is used to transiently increase the conductivity of a water solution. Its dissociation produces ions that act as cha....