iiinova — where your digital self keeps evolving

Reposted by Renzo Mancuso

cmn-vib.bsky.social @cmn-vib.bsky.social · 08/12/2025

Kicking off #CMNday2025 with technology deep dives and updates from the Rademakers and @mancusorenzo.bsky.social labs, by Elise Coopman and Maxim van Hoek. 🚀 @vibtechnologies.bsky.social @viblifesciences.bsky.social

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Renzo Mancuso @mancusorenzo.bsky.social · 14/10/2025

If the biology diverges, our treatments should too. Time to think about stratified immunomodulation in ALS. Grateful to the team, and especially Pegah Masrori, @baukje-bij.bsky.social @c9laura72.bsky.social , for leading the project, our partners, and the donors/families who made this work possible.

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Renzo Mancuso @mancusorenzo.bsky.social · 14/10/2025

Proud of this collaboration with Philip Van Damme’s team: we show that microglia and astrocytes behave differently in sporadic vs. C9orf72 ALS across human tissue, iPSC-derived cells and in vivo xenografts. www.nature.com/articles/s41...

nature.com

Client Challenge

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Renzo Mancuso @mancusorenzo.bsky.social · 14/05/2025

For me, it’s especially rewarding to see neuroimmunology gaining momentum—not as a silo, but as an integral part of how we tackle complex brain diseases. We’re building the infrastructure and community to ask deeper, more functional questions, and we’re doing it together as a team.

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Renzo Mancuso @mancusorenzo.bsky.social · 14/05/2025

We’re evolving CMN along two intersecting axes, neurogenetics and neuroimmunology, and backing that vision with strategic investments in talent, technology, and collaboration.

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Renzo Mancuso @mancusorenzo.bsky.social · 14/05/2025

Excited to share this new interview with Rosa Rademakers and myself, reflecting on the direction we're taking together with all our colleagues at the VIB-UAntwerp Center for Molecular Neurology. blog.vib.be/our-neurogen...

blog.vib.be

“Our neurogenetics legacy continues, but we’ve also made room for new directions”

Under the joint leadership of Rosa Rademakers and Renzo Mancuso, the Center is expanding its pioneering work in neurogenetics into neuroimmunology.

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Renzo Mancuso @mancusorenzo.bsky.social · 10/04/2025

This weekend, our teams @cmn-vib.bsky.social & our amazing lab are trading lab coats for running shoes! We're hitting the pavement to raise funds for Alzheimer's research — a cause close to our hearts and minds. Every step we take brings us closer to a cure. StopAlzheimer

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Renzo Mancuso @mancusorenzo.bsky.social · 08/04/2025

Hi Matthias Thanks! Email me please but in any case if you refer to the comparison table across species, each study is referenced on the x axis and is publicly available. Shoot me an email tho and I’ll be happy to help with anything :)

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Renzo Mancuso @mancusorenzo.bsky.social · 07/04/2025

Also big thanks to @natureneuro.bsky.social for letting us share our views and thoughts with the community. If you want to contribute to the web tool please reach out to us @viblifesciences.bsky.social, @cmn-vib.bsky.social and @uantwerpen.be

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Renzo Mancuso @mancusorenzo.bsky.social · 07/04/2025

We also offer to you a very simple and user friendly tool that will help you with your next microglial cell state annotation adventure! mancusolab.bioinf.be/microglia/in....

mancusolab.bioinf.be

Microglia Annotation Tool: a transcriptional subtype detector

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Reposted by Renzo Mancuso

cmn-vib.bsky.social @cmn-vib.bsky.social · 02/04/2025

Laura Fumagalli (@mancusorenzo.bsky.sociallab) was recently awarded a pilot grant from Stichting Alzheimer Onderzoek. 🙌 This grant will support her research on the role of microglia in ALS and FTD. mancusolab.sites.vib.be/en/news#/ne…

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Reposted by Renzo Mancuso

Shane Liddelow @liddelowsa.bsky.social · 10/12/2024

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)

nature.com

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology

This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

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Renzo Mancuso @mancusorenzo.bsky.social · 20/11/2024

Can I be added please? Thanks :)

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Renzo Mancuso @mancusorenzo.bsky.social · 17/11/2024

Of course you are in! We are all one big family :) Can I also be part of the astrocytes one pretty please?

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Renzo Mancuso @mancusorenzo.bsky.social · 17/11/2024

All those that reacted so far have been added :) Please keep commenting here or DM me if you want it!

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Reposted by Renzo Mancuso

Nicola Fattorelli @nicola-fattorelli.bsky.social · 16/11/2024

Hi Bluesky 🦋 I’m Nico, a microglia enthusiast based in VIB, Belgium 🧠 if you are curious about the science we do, take a look at our latest work! Here we use xenotransplantation models to map the spectrum of human microglia responses to Alzheimer’s disease pathology www.nature.com/articles/s41...

nature.com

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology - Nature Neuroscience

Human microglia transplanted in the mouse brain mount a multipronged response to amyloid-β pathology, displaying unique transcriptional states. Alzheimer’s disease risk genes are differentially regula...

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Reposted by Renzo Mancuso

Nicola Fattorelli @nicola-fattorelli.bsky.social · 17/11/2024

Microglia community, let’s start the discussion 🧠 follow the Microglia Starter Pack and ask @mancusorenzo.bsky.social to add your colleagues as they join Bluesky 🦋 go.bsky.app/DT3Cp4A

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Reposted by Renzo Mancuso

Dementia Researcher @dementiaresearcher.bsky.social · 17/11/2024

The Dr Sebastiaan De Schepper Lab at VIB, Belgium is recruiting for a Laboratory Technician working on Gut-Immune-Brain Axis Research. www.dementiaresearcher.nihr.ac.uk/job/laborato...

dementiaresearcher.nihr.ac.uk

Laboratory Technician - DEMENTIA RESEARCHER

The Dr Sebastiaan De Schepper Lab at VIB, Belgium is recruiting for a Laboratory Technician working on Gut-Immune-Brain Axis Research

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