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Nicholas Tay

@malayoman.bsky.social

63 followers 131 following 9 posts

Hobbyist scientist for life

Posts Replies Media

Reposted by Nicholas Tay

Rob Oslund @roboslund.bsky.social · 10/09/2026

Nearly a decade ago, Niyi and I began exploring photocatalysis to map protein spatial organization. Our new @nature.com paper shows how protein proximity can reveal therapeutic target pairs and guide multispecific medicines. www.nature.com/articles/s41...

nature.com

Proximity-guided graph learning reveals tumour-associated proximity antigens - Nature

A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances&nbsp...

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Nicholas Tay @malayoman.bsky.social · 19/05/2026

Yea but imagine the tears on Sunday when city wins on goal difference

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Nicholas Tay @malayoman.bsky.social · 03/05/2026

Slot watched the first half and thought, what if we play like United?

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Nicholas Tay @malayoman.bsky.social · 06/01/2026

Third and CL wouldn’t be a bad season imo esp if there are clear signs that they will not abandon this rebuild

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Nicholas Tay @malayoman.bsky.social · 31/08/2025

Set piece FC got out set-pieced

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Nicholas Tay @malayoman.bsky.social · 06/05/2025

Congrats!!

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Nicholas Tay @malayoman.bsky.social · 23/04/2025

To be honest I’d prefer a 9-0 trashing at anfield but I’ll take the Darwin equalizer

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Nicholas Tay @malayoman.bsky.social · 05/04/2025

Thanks Neel! This work is built off the long history of intein work that you and Adam Stevens did back in the day, so we have y’all to thank. To be honest the paper reads like a love letter to inteins!

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Nicholas Tay @malayoman.bsky.social · 05/04/2025

Thanks Stephanie! Looking forward to catching up at Bioorganic!

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Reposted by Nicholas Tay

Nature Biotechnology @natbiotech.nature.com · 04/04/2025

Employing engineered split inteins to replace the internal regions of target proteins in a single reaction. www.science.org/doi/10.1126/... #NBThighlight

science.org

Protein editing using a coordinated transposition reaction

Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...

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Nicholas Tay @malayoman.bsky.social · 04/04/2025

Excited to share that our protein editing method from the Muir Lab is now published in @science.org We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules www.science.org/doi/10.1126/...

science.org

Protein editing using a coordinated transposition reaction

Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...

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Reposted by Nicholas Tay

Stephanie Smelyansky @ssmelyansky.bsky.social · 16/11/2024

If you’re checking out the GRS, apply to our big sibling conference, the 2025 Bioorganic Chemistry GRC! The speaker list this year is insane 🤩 the GRC is truly my favorite conference to attend and I can’t wait to see everyone there next summer!

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