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Nicholas Tay

@malayoman.bsky.social

63 followers 131 following 9 posts

Hobbyist scientist for life

Posts Replies Media

Reposted by Nicholas Tay

Rob Oslund @roboslund.bsky.social · 10/09/2026

Nearly a decade ago, Niyi and I began exploring photocatalysis to map protein spatial organization. Our new @nature.com paper shows how protein proximity can reveal therapeutic target pairs and guide multispecific medicines. www.nature.com/articles/s41...

nature.com

Proximity-guided graph learning reveals tumour-associated proximity antigens - Nature

A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances&nbsp...

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Reposted by Nicholas Tay

Nature Biotechnology @natbiotech.nature.com · 04/04/2025

Employing engineered split inteins to replace the internal regions of target proteins in a single reaction. www.science.org/doi/10.1126/... #NBThighlight

science.org

Protein editing using a coordinated transposition reaction

Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step...

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Nicholas Tay @malayoman.bsky.social · 04/04/2025

Excited to share that our protein editing method from the Muir Lab is now published in @science.org We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules www.science.org/doi/10.1126/...

science.org

Protein editing using a coordinated transposition reaction

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Reposted by Nicholas Tay

Stephanie Smelyansky @ssmelyansky.bsky.social · 16/11/2024

If you’re checking out the GRS, apply to our big sibling conference, the 2025 Bioorganic Chemistry GRC! The speaker list this year is insane 🤩 the GRC is truly my favorite conference to attend and I can’t wait to see everyone there next summer!

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