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Vaclav Veverka

@vaclav-veverka.bsky.social

308 followers 188 following 4 posts

Senior group-leader at IOCB (Chromatin Structural Biology Lab)/Cell Biology, Charles University in Prague Transcription and epigenetics seen through networks of intrinsically disordered proteins

Posts Replies Media

Vaclav Veverka @vaclav-veverka.bsky.social · 21/09/2025

How do flexible regions of histone chaperones team up to handle histones? Together with Fred Winston’s lab @harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145

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Reposted by Vaclav Veverka

Harvard Med Cell Biology @harvardcellbio.bsky.social · 18/09/2025

New work from the Moazed lab reveals the requirements for establishment & epigenetic stability of mammalian heterochromatin! www.cell.com/molecular-ce...

cell.com

Requirements for establishment and epigenetic stability of mammalian heterochromatin

Tatarakis et al. study how H3K9me3 heterochromatin is formed and inherited in mammalian cells. Using a synthetic heterochromatin assembly system and genetic screens, they uncover requirements for init...

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Reposted by Vaclav Veverka

Lucas Farnung @lucas.farnunglab.com · 29/08/2025

🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...

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Vaclav Veverka @vaclav-veverka.bsky.social · 23/07/2025

Chromatin remodelers engage with transcription factors through β-catenin. A new story from @hodgeshc.bsky.social and @cermakova.bsky.social in Mol Cell reveals a key role for intrinsically disordered regions. Congratulations! We're really happy to help out.

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Vaclav Veverka @vaclav-veverka.bsky.social · 10/06/2025

#TCTeAC awesome crowd

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Vaclav Veverka @vaclav-veverka.bsky.social · 28/05/2025

Exploring unsettled biomolecular interactions with an NMR twist. A joint effort with the Obsil lab. www.nature.com/articles/s41...

nature.com

Structural plasticity of the FOXO-DBD:p53-TAD interaction - Nature Communications

Interactions between human transcription factors Forkhead box O4 (FOXO4) and p53 promote cellular senescence and activate p21 transcription. Here, the AUs use NMR to characterise the transient nature ...

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