If reviewers can’t reliably tell the difference between top grant proposals, why should they pretend they can? A new wave of funders is turning to lotteries to break the tie.

To the Editor: In the Ez-PAVE trial conducted in South Korea, Lee and colleagues (April 9 issue)1 report that intensive lowering of the low-density lipoprotein (LDL) cholesterol level to a target o...

Researchers are racing to regrow the thymus, an ephemeral immune organ, in the hope that it will slow ageing.

The new pills can lower cholesterol levels far below what can be achieved with statins, clinical trials have shown.

Recurrent focal segmental glomerulosclerosis (rFSGS) remains one of the most feared complications after kidney transplantation. Recurrence occurs in approximately one-third of patients with primary FS...

BackgroundThe mouse heterotopic heart transplant model is a widely used system for dissecting mechanisms of graft rejection and identifying new therapeutic t...

Antibody-mediated rejection (AMR) is a leading cause of kidney transplant failure and is primarily driven by donor-specific anti-HLA antibodies (DSA), althou...

Recurrent primary focal segmental glomerulosclerosis (FSGS) after kidney transplantation remains a major cause of early graft dysfunction and loss.1 Increasing evidence implicates natural IgM antibodi...

Recurrent primary focal segmental glomerulosclerosis (FSGS) after kidney transplantation remains a major cause of early graft dysfunction and loss.1 Increasing evidence implicates natural IgM antibodi...

To the Editor,

“I am now forging a more creative path,” this professor writes

Urinary single-cell RNA sequencing (scRNA-seq) provides a noninvasive and mechanistically informative approach for studying kidney allograft biology. We established a high-quality urinary scRNA-seq wo...

ABSTRACT. Vitamin D and erythropoietin (EPO) are kidney-derived hormones classically known for their roles in mineral metabolism and erythropoiesis, respec

An abstract is unavailable.

CDER proposes to withdraw approval of TAVNEOS

YouTube video by American Society of Transplantation

Podocytopathies, including minimal change disease and focal segmental glomerulosclerosis, represent the leading causes of nephrotic syndrome in children and adolescents. Although traditionally conside...

Many Democrats making the switch to politics are motivated by the Trump administration’s cuts to science — whereas energy and AI are a pull for some Republicans.

Xhuliana Kajana, Agnese Spennacchio, Francesca Chiara Viazzi, Carolina Bigatti, Pasquale Esposito, Angelica Parodi, Gianluca Caridi, Daniela Picciotto, Mar

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease, resulting in substantial morbidity and mortality globally. Advances in molecular geneti...

Overactivation of the alternative complement pathway contributes to IgA nephropathy and glomerular inflammation. In the 9-month interim analysis of this phase 3 trial, iptacopan, a complement facto...

In current clinical practice, successful kidney transplantation requires lifelong immunosuppression to prevent graft rejection, which is unfortunately associated with significant morbidity, mortality,...

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Galactose-deficient IgA1 (Gd-IgA1) plays a key role in IgA nephropathy (IgAN), but the location of the plasma cells responsible for its production remain unknown.

In a last-ditch effort, rescuers were at last able to free a 40-foot humpback whale that had been stuck in shallow waters near the coast of Germany for four days.

Although transplant glomerulitis often signifies antibody-mediated rejection (AMR), the pathophysiology of complement degradation split-product 4d (C4d) staining of peritubular capillaries (C4dptc) an...

The principle that medicines should not reach patients without strong safety guardrails forms the bedrock of the US Food and Drug Administration (FDA). The FDA shapes decisions about which medicines r...

Bones of 15,800-year-old puppy push confirmed origin of our canine companions back nearly 5000 years

Membranoproliferative glomerulonephritis (MPGN) has undergone a change in classification that is focused on the etiology of MPGN. Thus, MPGN is classified into immune-complex (IC)-mediated MPGN and co...

Paolo Cravedi with Udpates on Kidney Transplantation from the WTC 2025 🙌The link to the full article can be found in our Bio 🔗#transplantation #kidneytransplant #worldtransplantcongress #transplantimmunology #paper

In membranous nephropathy (MN), subepithelial immune deposits and glomerular basement membrane (GBM) thickening are defining lesions, yet how circulating anti-phospholipase A2 receptor 1 (PLA2R1) IgG ...

Down-regulation of swine leukocyte antigen expression supports graft survival after allogeneic lung transplantation in minipigs.

New therapeutics are needed to address the rapid progression of calcium oxalate (CaOx) nephrolithiasis and life-threatening kidney failure afflicting infants and young adults with one of the three dif...

A behavioural intervention programme to promote fluid intake for secondary stone prevention did not reduce recurrent stone events but modestly increased urine volume compared with guideline-based care...

White House review of agency spending plans for this year is causing delays

Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...

Polyamines, particularly spermidine, are well-documented for their cardiovascular protective, antitumor, and longevity-promoting properties. However, their role in heart transplantation, and specifica...