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Maddy Newby

@maddynewby.bsky.social
29 followers 33 following 1 posts

Senior Research Fellow studying Viral Glycobiology at the University of Southampton in the Crispin lab

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Reposted by Maddy Newby
GlycoShape @glycoshape.org · 09/10/2026
Phenomenal #glycotime by Meg Lunn-Halbert, Joel Allen and colleagues demonstrates through de novo protein design how steric hindrance controls N-glycan maturation ⬇️ doi.org/10.64898/202... Protein design with RFdiffusionAA coupled with glycosylation with GlycoShape 🧪
screenshot of Fig. 2 in the paper, titled "Systematically altering steric restriction controls glycan processing" the following corresponds to the figure caption in the paper.
Panel a, AF3-predicted protein with GlycoShape-modeled Man9 glycan (green) for glycoproteins THRgly1-4. b-d, Deconvoluted intact
mass spectra for analyzing native glycosylation with 1–3 major peaks corresponding to glycosylation shifts labeled. Glycans
matching in theoretical molecular weight to the corresponding shift are schematically annotated as follows: mannose residues as
green circles, N-acetyl glucosamine residues as blue squares, galactose as yellow circles, sialic acid as pink diamonds, and glucose
as blue circles. Unglycosylated sizes are estimated based on predicted MW and labeled, when present. b: Native glycosylation. c:
Native protein digested with Endo H. d: Overlaid protein from kifunensine-treated cells (color, solid line) and digested with Endo H
(gray, dotted line). Estimated predominant glycans present are shown in MW (Da) differences from predicted unglycosylated size.
For peak table see Supplementary Data S3; amino acid sequences provided in Supplementary Data S1.
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Maddy Newby @maddynewby.bsky.social · 15/01/2026
Just finished reading this and it's suuuuuper cool!
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Reposted by Maddy Newby
Ben Schulz @benschulz.bsky.social · 09/09/2025
Super excited by our new #glycotime preprint! A long-term project from my group with awesome collaborator @elisafadda.bsky.social Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1... thread below 👇
media.tenor.com
a cartoon drawing of a pitcher and cup of sugar on a table
ALT: a cartoon drawing of a pitcher and cup of sugar on a table
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Reposted by Maddy Newby
bioRxivpreprint @biorxivpreprint.bsky.social · 07/09/2025
Regulation of N-glycosylation efficiency by eukaryotic oligosaccharyltransferase www.biorxiv.org/content/10.1101/202…
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Reposted by Maddy Newby
bioRxivpreprint @biorxivpreprint.bsky.social · 26/08/2025
Blood, sweat, and beers: investigating mosquito biting preferences amidst noise and intoxication in a cross-sectional cohort study at a large music festival www.biorxiv.org/content/10.1101/202…
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Reposted by Maddy Newby
Cell - a Cell Press journal @cp-cell.bsky.social · 02/05/2025
Now online! Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies
dlvr.it
Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies
To combat snake bites from diverse species, this work identifies broadly neutralizing antibodies from a donor hyperimmune to snake venom, and it demonstrates that a combination of two of the identified antibodies with an inhibitory drug can protect mice from envenomation by medically important snakes found around the world.
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Reposted by Maddy Newby
Albert Heck @hecklab.bsky.social · 18/04/2025
Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein | PNAS www.pnas.org/doi/10.1073/...
pnas.org
Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein | PNAS
Hepatitis C virus (HCV) currently causes about one million infections and 240,000 deaths worldwide each year. To reach the goal set by the World He...
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Reposted by Maddy Newby
Elisa Fadda @elisafadda.bsky.social · 31/03/2025
#bioRxiv support team in Southampton 😎! @emilyxlucas.bsky.social @maddynewby.bsky.social just FYI 💪🏻😊 @richardsever.bsky.social
Emily left, Maddy centre, Elisa right
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Reposted by Maddy Newby
bioRxivpreprint @biorxivpreprint.bsky.social · 09/01/2025
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes www.biorxiv.org/content/10.1101/202…
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