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m-joe.bsky.social

@m-joe.bsky.social
18 followers 23 following 4 posts
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Madhu Pai, MD, PhD @madhupai.bsky.social · 21/07/2026
👏🏽👏🏽 India approves it’s first vaccine for dengue www.reuters.com/business/hea...
reuters.com
Japanese drugmaker Takeda's Qdenga becomes first dengue vaccine approved in India
Takeda Pharmaceutical's dengue vaccine Qdenga has been approved by India's drug regulator, making it the first such vaccine to be cleared in the country, the Japanese drugmaker's ​India unit said on M...
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Madhu Pai, MD, PhD @madhupai.bsky.social · 05/05/2026
Great news! PM Carney announces Ms Louise Arbour is Canada's next governor general www.cbc.ca/player/play/...
cbc.ca
Carney announces Louise Arbour is Canada's next governor general
Watch CBC News special coverage as Prime Minister Mark Carney names former Supreme Court of Canada justice Louise Arbour as Canada's next governor general.
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Matthew Macauley @siglecdude.bsky.social · 28/04/2026
Excited to share some work that our lab co-led with @veredpk.bsky.social. Lots of data for anyone interested in Siglecs. Great work from Edward Schmidt with big support from @zeinab-jc.bsky.social. www.nature.com/articles/s41...
nature.com
An atlas of human siglecs integrates expression, affinity, and cis/trans sialoglycan recognition profiles - Nature Communications
Cells are coated with glycans that are linked to cellular recognition via sialic acid-binding immunoglobulin-like lectins (Siglecs). Here the authors present a resource characterising human Siglec exp...
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Madhu Pai, MD, PhD @madhupai.bsky.social · 31/03/2026
As always, innovations don’t automatically save lives It takes access to do that www.statnews.com/pharmalot/20...
statnews.com
Doctors Without Borders calls Gilead 'unconscionable' for refusing to sell HIV prevention drug to organization
The move came after months of talks in which Doctors Without Borders asked Gilead Sciences for a “limited” supply of lenacapavir.
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GlycoNet @glyconet.bsky.social · 31/03/2026
Congratulations to GlycoNet Investigator Dr. Matthew Macauley on receiving the Horace S. Isbell Award, recognizing his contributions to carbohydrate (sugar) research. Read more: canadianglycomics.ca/glyconet-inves… #Glycotime #Glycoscience
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Mathieu Decloquement @mathd34.bsky.social · 05/02/2026
On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem: 🔗 www.jbc.org/article/S002... Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime
jbc.org
Writers and Readers of Sialylation in Immunoregulation in Cancer
Sialic acids are the terminal monosaccharides of the glycocalyx that critically shape cell-cell interactions, and are strongly implicated in regulating immune recognition and tissue homeostasis. In ca...
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GlycoNet @glyconet.bsky.social · 03/02/2026
Immune cells use sugar molecules on their surfaces to communicate—but these signals can be hard to study. GlycoNet researchers at @ualberta.bsky.social developed balloon-like probes to help detect these subtle interactions, opening doors for future therapies. 🔗 canadianglycomics.ca/balloon-like...
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Chantzy @chantzy.bsky.social · 26/12/2025
The wife of the 44 year-old man who died this week in Edmonton after waiting 8 hrs in the ER with chest pain was told by hospital security staff she was "being rude" Are you supposed to just be super calm & polite while your spouse dies a preventable death in the hospital?
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Matthew Macauley @siglecdude.bsky.social · 12/11/2025
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
science.org
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.
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Association of Academic Staff University of Alberta @aasua.bsky.social · 29/10/2025
“No government that purports to uphold the rule of law and fundamental rights and freedoms of its citizens would ever take away the right to free collective bargaining and the right to strike."
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Mark Carney @mark-carney.bsky.social · 16/10/2025
Canada’s bail and sentencing laws are about to get a lot tougher.   We’re amending the Criminal Code to help keep violent criminals and repeat offenders off our streets, and we’re introducing stronger sentences for auto-theft, organised crime, and home invasion.
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R Michael Howard @ixcel.bsky.social · 23/08/2025
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Matthew Macauley @siglecdude.bsky.social · 14/06/2025
Very excited to share some work the Lab has been working on for a while. A new platform to probe Siglec ligands. Led by an incredible PhD student (Zeinab). Comes out of an ongoing fruitful collaboration with the Derda lab. Very open to feedback! www.biorxiv.org/content/10.1...
biorxiv.org
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglecs are immunomodulatory receptors that regulate immune cell function. A fundamental challenge in studying Siglec-ligand interactions is the low affinity of Siglecs for their ligands. Inspired by ...
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Matthew Macauley @siglecdude.bsky.social · 12/06/2025
New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social. www.biorxiv.org/content/10.1...
biorxiv.org
The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions
Siglec-10 is a sialic acid-binding immunoglobulin-like lectin implicated in immune regulation, yet its molecular basis for ligand recognition and functional role in immune modulation remain poorly def...
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The Athletic @theathletic.com · 30/05/2025
THE EDMONTON OILERS HAVE MADE IT BACK TO THE STANLEY CUP FINAL 🏆
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Non-Academic Staff Association (NASA) @nasatheunion.bsky.social · 06/05/2025
Voting on ratification of the tentative agreement is open for all NASA members until Thursday, May 8 at noon. Members should check their email for voting information. If you have any questions or issues, please contact the NASA office.
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Elisabeth Bik @elisabethbik.bsky.social · 07/04/2025
Scientists should try to repeat more studies, but not those looking for a link between vaccines with autism - the replication studies were done and found that there is, in fact, no link between vaccines and autism. theconversation.com/scientists-s...
theconversation.com
Scientists should try to repeat more studies, but not those looking for a link between vaccines with autism
Funding replicating research is important, but only when allocated well.
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CTV News Calgary @ctvnewscalgary.bsky.social · 23/03/2025
Snap election called, as Carney hopes to leverage leadership momentum amid trade war with U.S. www.ctvnews.ca/federal-elec...
ctvnews.ca
Snap election called, as Carney hopes to leverage leadership momentum amid trade war with U.S.
Prime Minister Mark Carney has called the 2025 federal election, sending the country into an early campaign, six months ahead of the fixed date.
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Emily Carter @emilycurates.bsky.social · 15/03/2025
#Octopus They are masters of underwater escape and camouflage.
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Mark Carney @mark-carney.bsky.social · 16/03/2025
I had an excellent call with President von der Leyen about the road ahead for Canada-E.U. trade. Canada and Europe are strong, reliable partners. In a shifting global economy, that matters more than ever. We’re ready to secure new transatlantic business opportunities together.
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m-joe.bsky.social @m-joe.bsky.social · 09/03/2025
Mark Carney is elected as the next Liberal party leader and won over 85% of the party votes cast!
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CTV News Calgary @ctvnewscalgary.bsky.social · 04/03/2025
‘These tariffs are unjustified’: Smith stands with Trudeau amid U.S. trade war www.ctvnews.ca/edmonton/art...
ctvnews.ca
‘These tariffs are unjustified’: Smith stands with Trudeau amid U.S. trade war
Premiers across the country, including Danielle Smith, are standing united against U.S. President Donald Trump as the country wakes up to a trade war.
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Madhu Pai, MD, PhD @madhupai.bsky.social · 04/03/2025
Yep, measles is preventable
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CTV News Calgary @ctvnewscalgary.bsky.social · 21/02/2025
From our friends at The Associated Press... Connor McDavid scores in OT to give Canada 3-2 win over U.S. in 4 Nations Face-Off final www.ctvnews.ca/sports/artic...
ctvnews.ca
Connor McDavid scores in OT to give Canada 3-2 win over U.S. in 4 Nations Face-Off final
Connor McDavid scored at 8:18 of overtime in the 4 Nations Face-Off championship game to give Canada a 3-2 victory over the United States on Thursday night as the North American rivals turned the last...
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The Beaverton @thebeaverton.com · 21/02/2025
Report: CANADA! CANADA! CANADA! CANADA! CANADA! CANADA!
Canada being the best at hockey and the best at everything and you can never defeat us and CANADA! CANADA! CANADA!
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Non-Academic Staff Association (NASA) @nasatheunion.bsky.social · 12/02/2025
25 students' associations have sent an open letter to the Alberta government urging it to "restore operating grant funding for the province's public and nonprofit post-secondary institutions (PSIs)." You can read the full letter at gsa-ualberta.ca/albertas-pos... #ableg #abpoli #abpse
gsa-ualberta.ca
Government of Alberta, You Can't Keep Cutting Class - Graduate Student's Association | University of Alberta
Today, we twenty-five students' associations of Alberta urge you to restore operating grant funding for the province's public and nonprofit post-secondary
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Matthew Macauley @siglecdude.bsky.social · 04/02/2025
We have a postdoctoral position open to help lead our CD33 project in microglia. Would be grateful if you could spread the word: macauleylab.ca/job-opening-...
macauleylab.ca
Job Opening – A Postdoctoral fellow or Research Associate – Macauley Lab
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CNN @cnn.com · 02/02/2025
A day after signing steep new tariffs on Mexico, Canada and China, President Trump acknowledged what economists, members of Congress and even some of his own aides – in their previous lives – have been saying: Americans may find themselves paying the costs.
cnn.it
With tariffs signed, Trump warns of ‘pain’ to come for Americans | CNN Politics
A day after levying steep new tariffs on Mexico, Canada and China, President Trump acknowledged what economists, members of Congress and even some of his own aides — in their previous lives — have bee...
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CNN @cnn.com · 02/02/2025
Canada and Mexico have announced retaliatory tariffs on US goods following Trump's announcement of steep levies on the 2 countries earlier in the day.
cnn.com
Live updates: Trump tariffs, executive actions and immigration news | CNN Politics
President Donald Trump has announced aggressive new tariffs on Canada, Mexico and China today. Follow for live updates.
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Madhu Pai, MD, PhD @madhupai.bsky.social · 21/01/2025
I hope other G7 and G20 countries will step up and fill the massive funding and leadership gap that the U.S. will leave, if it withdraws from @who.int www.cbc.ca/news/health/...
cbc.ca
Trump wants to pull U.S. from World Health Organization. Why the UN health body matters | CBC News
Germany said Tuesday it will try to dissuade U.S. President Donald Trump from pulling out from the World Health Organization as many global health experts fear the move could substantially weaken glob...
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Matthew Macauley @siglecdude.bsky.social · 22/01/2025
Our latest work on Siglec binding to sulfated glycans. Great help: @khookh.bsky.social, @pengwu.bsky.social ,@raflynn5.bsky.social. Fom 1st PhD graduate of the lab (Jaesoo Jung) and help from Edward, Zeinab, Jhon, Kelli, @tayloregray.bsky.social, and Chris from my lab. pubs.acs.org/doi/10.1021/...
pubs.acs.org
Understanding the Glycosylation Pathways Involved in the Biosynthesis of the Sulfated Glycan Ligands for Siglecs
Carbohydrate sulfation plays a pivotal role in modulating the strength of Siglec–glycan interactions. Recently, new aspects of Siglec binding to sulfated cell surface carbohydrates have been discovere...
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Elisabeth Bik @elisabethbik.bsky.social · 17/12/2024
Infamous paper that popularized unproven COVID-19 treatment finally retracted Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds @cathleenogrady.bsky.social reports. www.science.org/content/arti...
science.org
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
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Paul Eric @pauleric70.bsky.social · 11/12/2024
How cool is this ..the Canadian Pacific holiday train lit up ✨🎄✨🎄✨🎄✨
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Nicholas Fabiano, MD @ntfabiano.bsky.social · 01/12/2024
The SARS-CoV-2 spike protein stays in the brain after a COVID-19 infection. 🧵1/10
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Peng Wu @pengwu.bsky.social · 24/11/2024
With the Wen lab and @siglecdude.bsky.social, we screening a library of sulfated glycan ligands against human Siglecs, and found that sulfation and sialylation patterns serve as important determinants of Siglec binding affinity and specificity #glycotime pubs.acs.org/doi/10.1021/...
pubs.acs.org
Enzyme-Sialylation-Controlled Chemical Sulfation of Glycan Epitopes for Decoding the Binding of Siglec Ligands
Widely distributed in nature, sulfated glycan epitopes play important roles in diverse pathophysiological processes. However, due to their structural complexity, the preparation of glycan epitopes wit...
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