iiinova — where your digital self keeps evolving

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Push The Needle @pushtheneedle.bsky.social · 30/09/2025

This is great and also illustrates how frivolous and completely damaging design review is for housing in our city

Lucas Nivon @lucasnivon.bsky.social · 30/09/2025

Explaining #seattle housing politics to a New Yorker is hilarious. nimby position is new buildings only downtown. The far left most yimby position is brownstone height buildings near commercial centers. The notion of brownstone height everywhere or some taller buildings is outside polite discourse.

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Xiaojing Gao @synbiogaolab.bsky.social · 24/09/2025

Having often dealt with the frustration of binder-limited projects, we sought a more accessible source for nanobodies than yeast display or llama. Here we introduce Germinal, computationally designing antibody-like binders with such a hit rate that only tens need to be screened for each target.

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Alexey Amunts @amunts.bsky.social · 04/07/2025

Speak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.

science.org

Exclusive: Famed protein structure competition nears end as NIH grant money runs out

Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold

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Brent Toderian @brenttoderian.bsky.social · 26/06/2025

“Someone with a 1-hr car commute needs to earn 40% more to be as happy as someone with a short walk to work. On the other hand, if someone shifts from a long commute to a walk, their happiness increases as much as if they’d fallen in love.” #CityMakingMath 50 reasons to want more walkable cities.

fastcompany.com

50 Reasons Why Everyone Should Want More Walkable Streets

From making you live longer to making cities more resilient: If you want a reason to make your city more walkable, it's in here.

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Molly Knight @mollyknight.bsky.social · 21/06/2025

Job Garcia’s kidnapping by the Trump administration is the top story on the LA Times website right now. www.latimes.com/california/s...

A 37-year-old U.S. citizen who was tackled to the ground and arrested after filming federal agents at Home Depot on Thursday said he was held for more than an hour near Dodger Stadium, where agents boasted about how many immigrants they arrested.
"How many bodies did you guys grab today?" he said one agent asked.
"Oh, we grabbed 31," the other replied.
"That was a good day today," the first agent responded.
The two high-fived, as Job Garcia sat on the asphalt under the sun, he said.
Garcia was released on Friday from a downtown federal detention center. No apparent criminal charges have yet to be filed. He is one of several U.S citizens arrested during enforcement operations in recent days. Department of Homeland Security officias sav some trave ilegaly

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latimes.com
"You wanted it, you got it," the man yelled.
An agent handcuffed him so hard "that there was no circulation running to my fingers," Garcia said.
Pinned down, Garcia had difficulty breathing.
"That moment, I thought I could probably die here," he said.
The agent put Garcia's phone back in his pocket. The recording kept running.
As Garcia was put into a vehicle, his video captured an agent twice saying: "I've got one back here."
"You got one what?" Garcia shot back. "You got one what?"
He said an agent told him in broken Spanish to "wait here,' though it could not be heard on the video. -

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latimes.com
"I f- speak English, you f- dumbass," he clearly shouts back.
No agent asked if he was an American citizen, he said. Nobody asked for identification.
"They assumed that I was undocumented," he said later in an interview.
The video ends after about four minutes, while he is waiting in the van.
CALIFORNIA
Raid at a Home Depot in Hollywood shatters an immigrant refuge
June 20, 2025
Garcia asked an agent to get his wallet from his car, so he could prove he was a U.S. citizen. Another agent retrieved his ID, but he remained handcuffed.
They were so tight, his hands hegan to swell.

Garcia asked an agent to get his wallet from his car, so he could prove he was a U.S. citizen. Another agent retrieved his ID, but he remained handcuffed.
They were so tight, his hands began to swell.
The agents switched him to handcuffs that looked like shoelaces. They took off around a corner, stopped to shuffle him into another van and sped off down the 101 Freeway.
"I smeared my blood in their seat," he said.
And he thought, "They're going to remember me."

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Lucas Nivon @lucasnivon.bsky.social · 16/06/2025

One of the hardest things about growing up in #nyc and living elsewhere is the utter lack of Chinese Cuban restaurants #iykyk… Trader Joe’s plantains scratch that itch

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Seattle Indivisible @seattleindivisible.bsky.social · 10/06/2025

Excited to announce that Pramila Jayapal will be our featured speaker at the Rally before the JUNE 14th - Seattle NO KINGS MARCH. #nokings #DefendDemocracy #FightAuthoritarians #NoFascism

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Jan Kirsch, M.D., M.P.H. @drjanicekirsch.bsky.social · 13/06/2025

THE AMERICAN MEDICAL ASSOCIATION CALLS FOR A SENATE INVESTIGATION INTO RFK, JR. "The resolution’s sponsor, Dr. Jason Goldman, urged his colleagues to support the request for an investigation to ensure the AMA is not “on the wrong side of history.” chicago.suntimes.com/health/2025/...

chicago.suntimes.com

Investigate federal vaccine panel's overhaul, AMA urges Senate

Health and Human Services Secretary Robert F. Kennedy Jr., a longtime skeptic of vaccinations, said he ousted the CDC committee to restore "public trust in vaccines."

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Jonathan Cohn @jonathancohn.bsky.social · 31/05/2025

"If there were justice in the world, Musk would never be able to repair his reputation, at least not without devoting the bulk of his fortune to easing the misery he’s engendered." www.nytimes.com/2025/05/30/o...

nytimes.com

Opinion | Elon Musk’s Legacy Is Disease, Starvation and Death

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Lucas Nivon @lucasnivon.bsky.social · 29/05/2025

Temporary, but a clear win for HB1110 legal approach! Little fanfare is ideal really, when tensions run so high

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Chris Murphy @chrismurphyct.bsky.social · 28/05/2025

This guy stole $10 million from the employees of his nursing home to buy himself a luxury yacht and Cartier watches. He PLED GUILTY. And because his Mom gave Trump $1 million, he just got a pardon. And this story barely makes the news today. WTF. www.nytimes.com/2025/05/27/u...

nytimes.com

Trump Pardoned Tax Cheat After Mother Attended $1 Million Dinner

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Thiago Carvalho @cyrilpedia.bsky.social · 27/05/2025

'(...) we could end up with completely new treatments for some of these conditions (or for subsets of patients therein), but no matter what we're going to learn a tremendous amount about the role of B cells in their etiologies, from several different angles all at once' @dereklowe.bsky.social

science.org

Autoimmune Disease, Transformed?

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Cyrus Biotechnology @cyrusbio.bsky.social · 13/05/2025

Cyrus's CEO, Lucas Nivon, is the keynote speaker for Nucleate Seattle’s Activator Demo Day! Join us to hear him speak about Life Sciences Commercialization on May 14th at the Allen Institute. #Seattle #Biotech #Innovation lu.ma/18yj2jg3?tk=...

lu.ma

Nucleate Seattle: 2025 Demo Day · Luma

Please join Nucleate Seattle in celebrating our 2025 Activator cohort at our Demo Day! We invite all biotech and bio-entrepreneurial enthusiasts of all stages…

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Alexey Amunts @amunts.bsky.social · 08/05/2025

The structure of human sweetness: Cell Sweet receptor bound to two widely used artificial sweeteners: sucralose and aspartame. A single receptor that mediates all our responses to sweet-tasting compounds.

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Carl Zimmer @carlzimmer.com · 02/05/2025

Nature reports that the National Science Foundation has stopped awarding new grants and allotting funds to existing ones. All of them. @colincarlson.bsky.social says that unless the freeze is lifted, it “is going to destroy people's labs.” 2/10 www.nature.com/articles/d41...

nature.com

Exclusive: NSF stops awarding new grants and funding existing ones

US science funder also plans to screen grant applications for compliance with ‘agency priorities’.

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Lucas Nivon @lucasnivon.bsky.social · 22/04/2025

Great piece. Often try to explain this to tech people, they train on human data, it is often easily observable. In bio much of data is invisible to us, now we have transcriptomics, spatial bio, etc. Hubble telescope is an example, before that you can’t see so far! We need bio Hubbles

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Lucas Nivon @lucasnivon.bsky.social · 15/04/2025

So happy @openfold.io is growing! More exciting announcements coming soon about our new all atom model adding ligand and RNA/DNA

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Lucas Nivon @lucasnivon.bsky.social · 08/04/2025

Idea for a hit movie: 3 professors have their research funding cut. They bootstrap a startup on services revenue, using the services to create new niche products. No VC funding. It is called… Ghostbusters (that’s the actual plot!) #scisky #startups #vc #bootstrap

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Lucas Nivon @lucasnivon.bsky.social · 08/04/2025

Protein binder design workflows for everyone! #ai #biotech

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Chris Hayes @chrislhayes.bsky.social · 08/04/2025

They’re going to keep pushing until something stops them.

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Prof Peter Hotez MD PhD DSc(hon) @peterhotezmdphd.bsky.social · 05/04/2025

My first post on BlueSky, I could not access the same handle as my X (someone hacked into that one): So it's @peterhotez for X and @peterhotezmdphd for BlueSky I'm a pediatric-vaccine scientist based in Houston TX at our Texas Medical Center

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Carl Zimmer @carlzimmer.com · 04/04/2025

“Kennedy’s team requested that Marks turn over data on cases of brain swelling and deaths caused by the measles vaccine—data that Marks said doesn’t exist because there have been no such confirmed cases in the U.S.” www.wsj.com/health/healt...

wsj.com

Exclusive | Ousted Vaccine Chief Says RFK Jr.’s Team Sought Data to Justify Anti-Science Stance

Dr. Peter Marks says the new health secretary’s team wants to show vaccines aren’t safe while promoting dangerous and unproven treatments.

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Lucas Nivon @lucasnivon.bsky.social · 04/04/2025

Thinking about printers and #biotech #ai Why are printers so lame? Because the interface from software to real world is complex. Ink on paper is relatively simple but still not robust.

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Lucas Nivon @lucasnivon.bsky.social · 27/03/2025

Excited to present about OpenFold #ai consortium!

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Rachael Sirianni, PhD @docsirianni.bsky.social · 27/03/2025

They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...

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Chris Hayes @chrislhayes.bsky.social · 26/03/2025

Unidentified men grabbing someone off the street and putting her in a car because she wrote an op-Ed. This as flatly authoritarian as anything we’ve seen in this country in a very long time.

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Democrats @democrats.org · 26/03/2025

James Malone just flipped a Pennsylvania State Senate district that went for Trump by 15 points last year. This is what building Democratic power looks like. Congratulations, Senator-elect Malone!

Image of James Malone with the overlaid text, "Democrat James Malone wins special election for Pennsylvania State Senate"

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Lucas Nivon @lucasnivon.bsky.social · 25/03/2025

#urbanist bluesky. I'm developing an argument that missing middle and upzoning are in fiduciary interest of most big city companies. Supply side housing limits effectively tax younger employees and critically limits corporate growth (most payroll pays people w less housing equity)

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Acyn @acyn.bsky.social · 25/03/2025

Reporter: Are you so are you saying you're okay with the continued use of signal by administration officials? Trump: No, that's not what I said. It seems to be the number one used device or app, whatever you want to call it

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Lucas Nivon @lucasnivon.bsky.social · 25/03/2025

Excited to start introducing Cyrus's first clinical directions in dangerous Hematological autoimmune disease! #autoimmune #biotech #pharma #drugdiscovery #ai

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Joe Katz @joekatz45.bsky.social · 23/03/2025

Someone literally try to run over @teslatakedown.com protesters today. Terrorism aimed at actual people, not cars. I'm assuming this will get at least as much coverage as the property damage?

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Lucas Nivon @lucasnivon.bsky.social · 22/03/2025

So excited to read this. New ideas that are not mercantilism. Grow housing, tech, biotech, and transit! #urbanism @ezraklein.bsky.social is pointing a potent new direction

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Stephanie M. Lee @stephaniemlee.bsky.social · 21/03/2025

"On October 8, 1931, a law went into effect requiring every Italian university professor to sign an oath pledging their loyalty to the government of Benito Mussolini. Out of over 1,200 professors in the country, only 12 refused. All of them were immediately fired." www.chronicle.com/article/what...

chronicle.com

Opinion | What Autocrats Want From Academics: Servility

In 1931, Italian scholars were made to take loyalty oaths. Will that happen to us?

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Lucas Nivon @lucasnivon.bsky.social · 22/03/2025

This thread is amazing — about AI realism and the false hype of DOGE

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Jim Woodgett @jwoodgett.bsky.social · 20/03/2025

If you have ever authored a scientific paper, the text is now being used by META. So paywalls keep out people but not the META spiders.

Results of a search in LibGen, a database of sources for META AI training. All scientific papers appear to have been sourced.

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Brian Beutler @brianbeutler.bsky.social · 21/03/2025

It’s not a kitchen-table issue, nevertheless I find myself hoping Democratic leaders pipe up about Trump handing his top campaign donor our contingencies for war against a nuclear power where he makes cars.

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Jon Rauch @jonrauch.bsky.social · 20/03/2025

A friend drove two hours today for her breast cancer chemotherapy only to learn it was canceled due to NIH cuts. Clinical trial ended midstream. No treatment, no restart, no plan, no information. Her bro-in-law's chemo was also canceled.

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Patricia Zengerle @reuterszengerle.bsky.social · 19/03/2025

This is terrifying. Grabbed on the street and spirited away without any process for “views.”

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Mark Cuban @mcuban.bsky.social · 19/03/2025

The administration is removing phone support for Soc Security recipients. Making it more difficult for seniors to get their checks. It’s a back door way to cut SS benefits. Horrific. If you know anyone who is impacted, please help them get online to get their benefits approved

benefit.me

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Chris Hayes @chrislhayes.bsky.social · 17/03/2025

They want the unreviewable power to grab people and render them to a foreign gulag.

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