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Reposted by Lucas Massoth

AndrewFolpe @folpe-mn-st.bsky.social · 12/06/2025

#PathSky Laryngeal mass, older adult male. Primitive, highly vascular round cell neoplasm for the most part.

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Megan @megothelioma.bsky.social · 07/01/2025

This is a duodenal mass is a patient with inflammatory bowel disease presenting with 1 week of nausea and vomiting. What IHC do you want to order? #pathsky #pathology #histology

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AndrewFolpe @folpe-mn-st.bsky.social · 04/12/2024

#PathSky 34M with a jet-black mass next to the seminal vesicle. Melanoma? A very occasional psammoma body was present, and expression of PRKAR1A was completely lost. Malignant melanotic nerve sheath tumor (previously “melanotic schwannoma”) in an unusual location.

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AndrewFolpe @folpe-mn-st.bsky.social · 03/12/2024

#PathSky I’m afraid I need 6 images for this one…Older adult with a large retroperitoneal mass. Most of it looks like this. Desmin (shown), SMA, and caldesmon are strongly positive.

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Kevin Keel @ucpath.bsky.social · 03/12/2024

Here is a bipartisan #pathology case. It's relevent to DVMs and MDs. Lots of red (at least pink) and blue, too. Rhinoscopy and nasal biopsy from a dog. What’s your diagnosis? It's a classic. #vetpath #pathsky #Mesomycetozoea #pathology #respiratorypathology #endoscopy #rhinoscopy

Multiple nodules (slightly polypoid) protruding from nasal mucosa of a dog. The nodules are only slightly darker pink than the more normal mucosa.

Large, perhaps 200-micrometer-diameter, spherical organisns with a trilaminar wall and multiple smaller structures inside. It lies in the submucosa of the nose and is surrounded by macrophages, lymphocytes and plasma cells.

Spherical organisms of variable diameter but typically very large, with a thick capsule and grainy contents. These structures have thick walls, but only the largest has a trilaminar wall. The organisms are in the submucosa of the nose and are surrounded by macrophages, lymphocytes and plasma cells. Some macrophages contain hemosiderin.

Large spherical organisms of variable diameter with a thick capsule and granular contents. Some have a nucleus visible in the center. The largest is partially collapsed and has a trilaminar wall. The walls of smaller (developing) organisms only have one layer.

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AndrewFolpe @folpe-mn-st.bsky.social · 25/11/2024

#PathSky. Mass next to knee, 27F. A hypocellular tumor with striking vascular changes, like we see in pleomorphic hyalinizing angiectatic tumor or schwannoma. But also some small fascicles of monomorphic spindled cells and a calcification. SS18::SSX fusion antibody +. Sneaky synovial sarcoma.

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Kevin Keel @ucpath.bsky.social · 22/11/2024

Now that I have a few followers, most of whom are pathologists, I thought I'd give you an unknown. This is small intestine from a dog. What's your diagnosis? Any rule-outs? Our Biopsy Conference participants had one principal rule-out with two alternates.

Small intestine from a dog with a predominately histiocytic infiltrate. Macrophages contain numerous, very small organisms.

Small intestine from a dog with chronic inflammation.

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AndrewFolpe @folpe-mn-st.bsky.social · 21/11/2024

#PathSky Scalp mass, 33M. Just a nice example of soft tissue Rosai-Dorfman disease. I think this low power “pale->pink->blue” look is a good low power clue. In addition to S100 protein, Karen Rech’s group here at Mayo have shown OCT2 to be valuable in this dx. pubmed.ncbi.nlm.nih.gov/33177341/

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Dane @dhisto.bsky.social · 15/11/2024

This, as featured in my avi, was a cute little finding. Enterobius in a tubular adenoma #pathology #GIPath #histology #histopathology

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Dan Berney @danberney.bsky.social · 21/11/2024

A nasty testis in a teenager. Any guesses? #pathsky #gupath

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Lucas Massoth @lucasmassoth.bsky.social · 21/11/2024

Nodular lymphocyte predominant Hodgkin lymphoma exhibiting characteristic PD1+ T-cell rosettes around tumor cells #Pathsky #Pathology #Hemepath

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Matthew Wasco @gleason4plus5.bsky.social · 20/11/2024

I called this a tonsillar fibroma since I didn't know what else to call it, but it's a great section! Almost like the tonsil has its own uvula. #pathsky #pathology

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AndrewFolpe @folpe-mn-st.bsky.social · 20/11/2024

#PathSky I try not to talk about it, but sometimes I look at bone cases. Lytic sacral lesion, 69M. Among the many IHC it was sent with, CD31 and KIT were diffusely positive, but other endothelial and GIST markers were negative. Dx? Anything else you’d like?

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Dr. Autopsy, DO @drautopsy.bsky.social · 20/11/2024

Hybrid tumor: Oncocytoma and Chromophobe Renal cell Carcinoma! #GUpathsky #pathsky #pathology #surgicalpathology #pathart #Nephsky

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AndrewFolpe @folpe-mn-st.bsky.social · 20/11/2024

Ok, my third attempt at a first post. I like surgical pathology and sharing cases. New genetic promiscuity. Superficial neurocristic EWSR1::FLI1 fusion tumor. Same fusion as Ewing sarcoma but benign. There is life in this whole morphology thing yet. pubmed.ncbi.nlm.nih.gov/38866368/ #PathSky

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Lauren Smith, MD, HEC-C @lbsmithmd.bsky.social · 19/11/2024

Patient with #CLL and geographic necrosis. What is dx? #pathsky #hemepathsky #hemesky #medsky

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Emory University Department of Pathology & Laboratory Medicine @emorypathology.bsky.social · 19/11/2024

🔬Quiz yourself with a past #EmoryCoTW A bone marrow aspirate shows cytoplasmic vacuoles in myeloid and erythroid precursors (see images). Which nutrient deficiency should be considered? #PathSky #Pathology #PathResidents #MedSky #Path2Path #PathMatch25 #PathMatch2025

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 19/11/2024

Granular cell tumor (GCT), tongue, H&Es, 10x and 40x & CD68 and S100, 20x: Large round to oval tumor cells with indistinct eosinophilic, granular cytoplasm - CD68, S100, and SOX10 positive! #pathology #pathsky #surgicalpathology #granularcelltumor #gct #headandneckpathology #pathart

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Lucas Massoth @lucasmassoth.bsky.social · 19/11/2024

Touch preparation of high-grade mullerian serous carcinoma presenting as a large abdominal mass, performed at the time of frozen section. Although not always additive, touch preparations can be a useful adjunct to evaluate tumor morphology intraoperatively #pathsky #medsky #pathology #gynpath

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🧬Jason V. Freddybaum, MD🧬 (he/him) @mopathguy.bsky.social · 19/11/2024

So glad you asked! To start, you can’t just train a set on randomly submitted diagnostic information. You need good curated information about the patients’ history. You need appropriate numbers of both positive and negative examples of all target conditions. 1/4 #pathsky #medsky

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Magic Mel @magicmel.bsky.social · 19/11/2024

Amyloid! Everyone’s favourite exam question. Seen here in a bladder biopsy for investigation of haematuria. A not uncommon isolated finding in this location. Amorphous eosinophilic material in the lamina propria, in this case associated with vessel walls. #pathsky #pathresidents

Microscopic image of a bladder biopsy stained with haematoxylin and eosin. The urothelium is normal. The lamina propria shows amyloid deposition around vessel walls. There is associated interstitial haemmorrhage.

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Kamran Mirza MD PhD @kmirza.bsky.social · 18/11/2024

A few years ago, I got temporarily stumped by the morphology of these circulating leukocytes... Any guesses what these cells are? What's the diagnosis? #hemepathsky #hemesky #pathsky #bloodsky #UMichPath

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EK MD, FCAP, FASCP, member of USCAP/ASC/PAPS @pathologist.bsky.social · 18/11/2024

Microglandular adenosis (MGA), breast, H&E, 10x and 40x: A rare breast lesion! #pathology #pathsky #surgicalpathology #breastpathology #microglandularadenosis #MGA

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Lucas Massoth @lucasmassoth.bsky.social · 18/11/2024

‘Starry sky’ appearance of Burkitt lymphoma, here involving testicle #pathsky #medsky #pathology #hemepath

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Reposted by Lucas Massoth

Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 16/11/2024

Interesting case of ANCA GN apparently triggered by COVID infection. Also showed concurrent membranous features with MPO+(IHC below) IgG (IF below) deposits as has been described: www.sciencedirect.com/science/arti.... #renalpath #nephrology #pathsky

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Lucas Massoth @lucasmassoth.bsky.social · 15/11/2024

Happy Friday everyone! Extranodal marginal zone lymphoma involving salivary gland, seen forming lymphoepithelial lesions #pathsky #medsky #pathology #hemepath #oncology

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · 14/11/2024

It’s almost Friday so here’s a case of metastatic papillary thyroid carcinoma that now shows anaplastic transformation. The late great Dr Livolsi and I did a study on such brain metastases detailing the histologic and molecular features ❤️🧠🔬 #pathsky pubmed.ncbi.nlm.nih.gov/36889238/

Squash preparation showing many cells some with bizarre atypia

Close up view of a highly atypical cell with nuclear pseudoinclusions

H&E stained section showing high grade metastatic thyroid carcinoma with some hobnail features

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Lucas Massoth @lucasmassoth.bsky.social · 14/11/2024

Endocervical adenocarcinoma in situ (AIS). While HPV16 is the most frequent subtype detected in AIS, it shows a stronger association with HPV18 relative to high grade squamous lesions. #pathsky #medsky #pathology #gynpath

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Cristina Costales @ccpathmd.bsky.social · 13/11/2024

Christening my timeline with some favorite images of pesky pathogens. Can anyone name the two different organisms pictured on each H&E stain of BAL fluid? (#2 is harder 🤭) #pathsky #IDsky

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Lucas Massoth @lucasmassoth.bsky.social · 13/11/2024

Intrauterine perivascular epithelioid tumor (PEComa) exhibiting HMB45 expression by IHC. This lesion was small and lacked atypia or mitotic activity, predicting benign behavior. #pathsky #medsky #pathology

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Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 12/11/2024

Case of cellular rejection in a transplant kidney showing Bowman's capsulitis. Not a feature in Banff schema (yet); but has been associated with severe rejection. pubmed.ncbi.nlm.nih.gov/29501487/ #renalpath #nephrology #pathsky

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Lucas Massoth @lucasmassoth.bsky.social · 12/11/2024

Endometrial clear cell carcinoma exhibits architecture that ranges from papillary to tubulocystic to solid nests. Unlike its cervical counterpart, CCC of the uterine corpus shows no association with in utero exposure to diethylstilbestrol (DES) #pathsky #medsky #pathology #oncology

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Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · 11/11/2024

Myxopapillary ependymoma grossly has a characteristic sausage-shaped appearance. Commonly found associated with the filum terminale, it has a fibrillary glial appearance in a myxoid background. Though previously categorized as CNS WHO grade 1, it is now considered grade 2 #pathsky #medsky #neuropath

A sausage shaped tumor with attached filamentous band

A squash preparation of a fibrillary neoplasm with myxoid background

H&E stained section of papillae with myxoid cores

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Lucas Massoth @lucasmassoth.bsky.social · 11/11/2024

So-called ‘flame cells’ present in IgA plasma cell myeloma #pathsky #medsky #pathology #oncology

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Lucas Massoth @lucasmassoth.bsky.social · 10/11/2024

Nice example of nodal marginal zone lymphoma that exhibits plasmacytic differenitation and frequent dutcher bodies #pathsky #medsky #pathology

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Reposted by Lucas Massoth

Maria Gubbiotti, MD,PhD @mariagoobs.bsky.social · 10/11/2024

Sarcina photobombing! #pathsky

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Lucas Massoth @lucasmassoth.bsky.social · 10/11/2024

Sarcina Ventriculi present on gastric biopsy. This gram positive bacteria is notable for its construction in tetrads and its association with delayed gastric emptying, which may be rarely complicated by emphysematous gastritis and gastric perforation. #pathsky #medsky #pathology

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Lucas Massoth @lucasmassoth.bsky.social · 10/11/2024

Mast cells with atypical spindled morphology forming aggregates within the bone marrow, diagnostic of mastocytosis. In this case, there is coexistent chronic myelomonocytic leukemia (systemic mastocytosis with an associated hematological neoplasm) #pathsky #medsky #pathology

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