El trabajo fue liderado por el catedrático de la USC Miguel Vázquez López

Platinum(iv) prodrugs offer a promising strategy to overcome the limitations of cisplatin and oxaliplatin, including systemic toxicity and acquired resistance. In this study, two novel α-tocopherol su...

The influence of choline and geranic acid-based ionic liquids (CAGE ILs) on the anticancer activity of selected Pt(ii) and Pt(iv) complexes was investigated. All complexes exhibited appreciable solubi...

Here we report a C3-symmetric metal-binding tripeptide, BTMA-1, that self-assembles in water into either a chiral supramolecular helical polymer or a discrete CoII peptide helicate, depending on metal coordination. The CoII peptide helicate exhibits high affinity and selectivity toward DNA three-way junctions (3WJ), a class of noncanonical DNA structures with emerging biological relevance. Importantly, we demonstrate that the recognition process can be triggered dynamically by adding CoII ions to a dispersion of the supramolecular polymer, which acts as an inert precursor reservoir in physiological media. In this way, our strategy shows that chiral supramolecular helical polymers can form temporarily inactive aggregates that release discrete helicates for biomolecular recognition, such as 3WJ binding, upon metal ion coordination. Overall, this mechanism reveals a previously unexplored capability of this class of materials and offers a new approach for the design of responsive supramolecular systems for nucleic acid recognition and anticancer therapy.

Kimika Fakultatearen 50. urteurrena dela eta, 50 urte kimika zabaltzen zikloa antolatu da, bertan Kimika Fakultateko kideek Fakultatean garatzen diren hainbat gairen inguruan arituko dira, publiko oro

Con motivo del 50 aniversario de la Facultad de Química, la Universidad del País Vasco (UPV), el Centro de Física de Materiales (CFM) y Donostia Kultura han organizado un ciclo de 10 conferencias.

Cyclopentadienyl (Cp) Ru(IV) quinoline complexes are known for their role in bioorthogonal catalysis within cellular environments, where they use endogenous GSH to deprotect profluorescent and prodrug substrates. However, their reactivity toward GSH and potential for redox-mediated therapies remain underexplored. This study presents RuQ-TARF, a Cp-Ru(IV) complex with a quinoline ligand linked to 2′,3′,4′,5′-tetraacetylriboflavin (TARF) as a redox-active moiety. Its catalytic activity in oxidizing GSH and activating a Pt(IV) prodrug of oxaliplatin was investigated. RuQ-TARF catalyzes the oxidation of GSH to GSSG, improving electron transfer compared to RuQ, its flavin-free analogue. LC–MS analysis showed that activating the Pt(IV) prodrug with GSH produces multinuclear Pt(II)-GS species. RuQ-TARF was additionally evaluated during coincubation with GSH and NADH under blue light, where NADH enabled faster activation of the prodrug, producing oxaliplatin as confirmed by 1H and 195Pt NMR. Cyclic voltammetry showed that linking TARF to RuQ improves the reversibility of redox processes, enhancing catalytic performance and supporting its use in combined GSH oxidation and prodrug activation strategies.

La UPV/EHU organizará una serie de conferencias con científicos y otras actividades como visitas guiadas a laboratorios

Methylene blue acts as a photocatalyst in the presence of biologically relevant electron donors, enabling red-light conversion of two Pt(IV) complexes into cisplatin and oxaliplatin. Spectroscopy and...