Abstract. In recent years, gold(I) complexes have attracted increasing interest as an alternative to conventional metallo-chemotherapeutic agents. Their mo

A series of novel oxaliplatin(iv) complexes bearing monohaloacetic acids (MAAs) were synthesised to address the limitations of platinum-based chemotherapy related to severe side effects and resistance phenomena. Both symmetrical [Pt(DACH)(ox)(MAA)2] and asymmetrical [Pt(DACH)(ox)(MAA)(OAc)] derivatives featuring mo

Four novel gold(I) N-heterocyclic carbene (NHC) complexes were synthesized and characterized; they are tuned in terms of the aromatic extension of the NHC sc...

In palladium(II) complexes with the general formula [PdAB2], the choice of the bidentate ligand A drives a different binding mode toward double-stranded DNA and is crucial for conferring cytotoxic pr...

Platinum(iv) prodrugs offer a promising strategy to overcome the limitations of cisplatin and oxaliplatin, including systemic toxicity and acquired resistance. In this study, two novel α-tocopherol su...

Combinare farmaci già utilizzati con agenti chemioterapici al platino per rendere più efficaci e selettivi i trattamenti per la leucemia promielocitica acuta. La ricerca di Francesca Binacchi