Thrilled to share the publication of our latest piece of research in #ScienceTranslationalMedicine, in collaboration with and led by the amazing @labpuissant.bsky.social and Camille Vaganay.
Why does acute myeloid leukemia (AML) so often relapse after chemo works at first?
tinyurl.com/mt932jky
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tinyurl.com
Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in human and mouse acute myeloid leukemia
Chemoresistance in acute myeloid leukemia depends on an active PAK1-CLK1/4-SRRM1 splicing network that can be targeted to prevent relapse.
