Excited to share our latest study with @lobrylab.bsky.social! Using multiple AML models, we identified splicing dysregulation as a key feature of chemoresistance and relapse in AML. @institut-leucemie.bsky.social #ScienceTranslationalMedicine
tinyurl.com/mt932jky
tinyurl.com
Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in human and mouse acute myeloid leukemia
Chemoresistance in acute myeloid leukemia depends on an active PAK1-CLK1/4-SRRM1 splicing network that can be targeted to prevent relapse.