Male breast cancer affects about 2,800 US men a year. Five facts on hidden symptoms, BRCA2 genetics, risk factors and treatments could change when men act.

Hereditary cancer is often associated with the maternal side of a family, but fathers can pass genetic mutations to their children as often as mothers

After watching her mom and grandmothers battle breast cancer, ABC News Live coordinating producer Rachel Katz chose to have a preventative double mastectomy. Her journey to surgery was far from easy.

Learn how hereditary breast cancer research is uncovering inherited risk factors, genetic mutations, and new approaches to prevention and treatment.

Premenopausal women carrying a BRCA1 or BRCA2 mutation are frequently advised to undergo risk-reducing bilateral salpingo-oophorectomy (BSO) to lower their significantly increased lifetime risk of ova...

In a Q&A, Yale cancer scientist Luisa Escobar-Hoyos explains the challenges within pancreatic cancer treatment — and how patient outcomes can be improved.

"People imagine a nurse quits after one traumatic night or a tragic patient death. That is not how it happens."

A breast medical oncologist explains what to know about determining your breast cancer risk using online risk assessment tools including Tyrer-Cuzick and The Gail Model.

Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.

An international group have discovered associations between pathogenic variants of the BRCA 1 and 2 genes and four types of cancer. Published in ESMO Open, the findings expand the potential for p...

You want the most effective treatment for your breast cancer. Learn how molecular diagnostics can guide your doctors toward a treatment that works best for your tumor.

IntroductionGenetic testing for inherited cancer risk syndromes can inform targeted surveillance and intervention, but testing for male patients is inadequat...

This cohort study analyzes cancer risk and surgical complications after risk-reducing mastectomy for BRCA1 and BRCA2 carriers.

Study finds risk-reducing mastectomy in BRCA1/2 carriers significantly cuts cancer risk but offers no overall survival benefit over intensive surveillance.

Damaging variants in genes involved in a rapid immune response (innate immunity) are significantly linked to earlier breast cancer onset in carriers of the harmful BRCA1 genetic mutation, reveal preli...

The clinical implications of specific pathogenic and likely pathogenic variant (LP/PV) types and locations in the BRCA1 or BRCA2 tumor-suppressor genes remain to be elucidated.

In a compelling advance for cancer genetics and epidemiology, a groundbreaking study has been published exploring the interplay between natural reproductive milestones and breast cancer risk among

Amy Byer Shainman is a BRCA1 carrier and a previvor advocate known as BRCAresponder, an author, and a film producer behind feature film Love, Danielle.

Final project report: Social media for carriers of hereditary cancer syndromes

After discovering he carried the BRCA2 gene in 2013, one man began getting yearly mammograms. Twelve years later, he was still “shocked” to learn he had breast cancer and is now sharing his story to r...

'Reassuring' data show more breast cancers with surveillance, but no difference in survival

Lynch syndrome, caused by germline pathogenic variants in mismatch repair genes, markedly increases risks of endometrial, ovarian, and possibly breast…

NYU Langone has announced the appointment of Dr. Anirban Maitra, a pancreatic cancer researcher, as the new director of the Laura and Isaac Perlmutter Cancer Center.

Researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy found that an oral bacterium commonly associated with periodontal ...

Our genomes are filled with errors that were once impossible to correct. But in CRISPR, we finally found an extraordinarily powerful tool for treating genetic disease – and perhaps making better versi...

Dr Emil Lou breaks down what’s changing in pancreatic cancer care, including neoadjuvant chemotherapy, genomic testing, and why progress remains incremental.

In a phase 1b/2 trial, an off-the-shelf vaccine using gorilla adenoviral and modified vaccinia Ankara vectors with over 200 mutated peptides known to be present in persons with mismatch-repair-deficie...

A relevant proportion of malignancies predominantly or exclusively affecting women, including breast and gynecologic cancers, is attributable to hereditary tumor syndromes, profoundly impacting cancer...

“Angelina Jolie effect”: a measurable, sustained increase in genetic testing, cancer screening, and awareness worldwide.

Many of us are familiar with the BRCA1 and BRCA2 genes that, when mutated, are linked to an increased risk of breast cancer in women.…

Estrogen-only HRT tied to significantly lower risk, no adverse effect of combined hormones

In this younger age group, 84.7% of tumors were invasive

Mild dilatation of the main pancreatic duct (MPD) can be an early indicator of an obstructing mass, but its clinical significance in asymptomatic high-risk individuals (HRIs) undergoing surveillance h...

In the ongoing quest to understand the complexities of ovarian cancer, a groundbreaking study co-authored by Pokorna, Orlickova, Machackova, and their team sheds light on the genomic intricacies and

The UK NSC's proposed screening programme would invite 45 to 61-year-old men with BRCA mutations for a PSA test every two years.

Steve Merlin works with fellow pancreatic cancer patients, telling his remarkable story of surviving 13 years since his diagnosis.

We are heartbroken for Tatiana as she confronts Acute Myeloid Leukemia. Tatiana’s illness highlights the consequences of vaccine misinformation and the erosion of public trust.

A recent multicenter retrospective study has cast new light on the therapeutic potential of talazoparib, a potent PARP inhibitor, in patients with BRCA-mutant metastatic breast and ovarian cancers.

When I was diagnosed with leukemia, my first thought was that this couldn’t be happening to me, to my family.

Find out what Lisa Guzzardi is supporting. Check out the fundraisers, nonprofits, and causes that Lisa Guzzardi is supporting today.

Danielle tests positive for a BRCA1 gene mutation, a marker for developing breast and ovarian cancer. As her sister Amy undergoes chemotherapy for a breast cancer diagnosis, Danielle considers prevent...

While pancreatic cancer is the eighth most commonly diagnosed cancer in Australia, it’s estimated that it will be the third most common cause of death from cancer in 2025.

In a groundbreaking study poised to transform our understanding of genetic cancer risks, researchers have unveiled new insights into the differential impacts of BRCA1 gene founder variants on