Ye Lab @liye-tsri.bsky.social · 02/07/2026We propose an “energy minimization” view of learning. Neural circuits may optimize not only activity patterns or behavior but also energy cost. Understanding this could be critical for explaining the remarkable efficiency of biological intelligence. 3/3 181
Ye Lab @liye-tsri.bsky.social · 02/07/2026Using in vivo glucose sensors in behaving mice, we asked: what is the neuronal fuel cost of performing a learned task? Key finding: After learning, the same task required less fuel, suggesting learning may not only improve performance—it may lower the energy cost of computation. 2/3 0133
Ye Lab @liye-tsri.bsky.social · 02/07/2026Our new preprint is out!! The human brain runs on ~20 watts. Computers and modern AI systems require vastly higher energy. This gap raises a fundamental question: how does the brain compute so efficiently? In our new study, we take a critical step toward measuring and understanding this directly 1/3 56621
Ye Lab @liye-tsri.bsky.social · 10/06/2026We are looking for a Research Technician! see job posting here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...hhmi.wd1.myworkdayjobs.comResearch Technician - Ye LabPrimary Work Address: 10550 North Torrey Pines Road, La Jolla, CA, 92037 Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the d... 000
Reposted by Ye LabIshmail Abdus-Saboor @ishmailsaboor.bsky.social · 09/06/2026Congratulations to the 2026 McKnight Scholars! Great to see many friends amongst this cohort! www.mcknight.org/news-ideas/2...mcknight.org2026 McKnight Scholar AwardsThe Board of Directors of The McKnight Endowment Fund for Neuroscience is pleased to announce it has selected ten neuroscientists to receive the 2026 McKnight Scholar Award. 0192
Reposted by Ye LabHHMI @hhmi-science.bsky.social · 28/04/2026What's better than one #HHMIInvestigator being elected to the @nasonline.org? Ten! Meet the newest members, recognized by their peers for distinguished, ongoing contributions to original research: bit.ly/4cCxRuv. 0266
Ye Lab @liye-tsri.bsky.social · 03/04/2026Excited to share our latest work with @antihebbiann.bsky.social, revealing a top-down mechanism regulating the fragmentation of feeding, led by Tianbo Qi. www.biorxiv.org/content/10.6...biorxiv.org 083
Reposted by Ye LabAnn Kennedy @antihebbiann.bsky.social · 23/03/2026I had a great time talking to Meenakshi about my trajectory through neuroscience! Tune in for electric fish, imaging the hypothalamus, and trying to find a path in theory that stays relevant to the brain. Also, my early phd experiences of trying to do science when real life rears its head. 0369
Reposted by Ye LabGiordano Lippi @lippilab.bsky.social · 24/02/2026Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com. www.nature.com/articles/s41... Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️nature.comSingle-cell and isoform-specific translational profiling of the mouse brain - NaturePost-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp... 13821
Reposted by Ye LabLifeCanvas Technologies @lifecanvastech.bsky.social · 10/02/2026What if we could see 3D #biodistribution of cancer drugs at the cellular level... throughout an entire model animal? 🧐 A new paper from Li Ye's lab @scripps.edu, Zhengyuan Pang & Verina Leung et al. introduce a technique for doing just that. (1/3) 🧵 132
Ye Lab @liye-tsri.bsky.social · 22/12/2025Thrilled to share our latest work--combining CATCH with whole-body HYBRiD imaging, leveraging click chemistry to visualize and identify drug-targeted cells across organ systems. Led by a brilliant team: former PhD student Ben Pang and former undergrad Verina Leung. 1154
Reposted by Ye LabSimons Foundation @simonsfoundation.org · 21/12/2025Fellows-to-Faculty awardee Chen Ran maps the senses of internal organs. Receiving this award — which is currently open for apps — has been crucial in enabling his work: www.simonsfoundation.org/autism-and… #science 094
Reposted by Ye LabArdem Patapoutian @ardemp.bskyverified.social · 07/11/2025RIP Jim Watson. You inspired many of us to pursue a life in research. I wish you had made it easier for us to celebrate your legacy. 2657
Reposted by Ye LabYe Lab @liye-tsri.bsky.social · 09/11/2025Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though) 021
Ye Lab @liye-tsri.bsky.social · 09/11/2025Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though) 021
Ye Lab @liye-tsri.bsky.social · 03/11/2025Deeply honored to receive this year's Tianqiao and Chrissy Chen Young Investigator Award from @sfn.org Grateful to all lab members and my mentors. 2161
Reposted by Ye LabAnn Kennedy @antihebbiann.bsky.social · 14/10/2025Come be my newest colleague! Scripps neuro is an energetic and supportive department, and uniquely benefits from proximity to our intimidatingly awesome chem and drug discovery programs. Happy to chat about my experiences here so far! 0103
Reposted by Ye LabScripps Research @scripps.edu · 10/10/2025The NIH has awarded a $14.2M Director’s Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.scripps.eduScripps Research-led team receives $14.2M NIH award to map the body’s “hidden sixth sense” 012425
Reposted by Ye LabAnn Kennedy @antihebbiann.bsky.social · 09/10/2025Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain. A brief rundown... www.nature.com/articles/s41...nature.comA parabrachial hub for need-state control of enduring pain - NatureActivity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats. 912841
Reposted by Ye LabXin Jin @xinjin.bsky.social · 08/10/2025Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond. Free registration link: www.eventbrite.com/e/dorris-neu... 172
Ye Lab @liye-tsri.bsky.social · 03/07/2025What a small world!!! We left the island the next morning. 010
Ye Lab @liye-tsri.bsky.social · 20/06/2025Congrats to @xinjin.bsky.social @tinakim-neuro.bsky.social and many others! 1113
Reposted by Ye LabArdem Patapoutian @ardemp.bskyverified.social · 03/06/2025Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S. “Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.” Read the article here. No subscription required: www.nytimes.com/2025/06/03/u...nytimes.comThe U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming 722893
Reposted by Ye LabScripps Research @scripps.edu · 07/05/2025Congrats to Assist. Prof. Chen Ran (@chenran.bsky.social), one of just 15 selected as a 2025 Searle Scholar! 🌟 His work on how visceral signals are encoded in the brain was recognized for its potential to elucidate disease mechanisms & inform new therapeutics. More: ow.ly/HtLM50VN8sN 6446
Reposted by Ye LabAnn Kennedy @antihebbiann.bsky.social · 20/04/2025Congratulations to @chenran.bsky.social on being named a Searle Scholar! searlescholars.org/2025/04/14/s...searlescholars.orgSEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2025Members of the new class of Searle Scholars pursue ground-breaking research in chemistry and the biomedical sciences. Each receives an award of $300,000 in flexible funding to support his, her, or … 2242
Reposted by Ye LabChen Ran @chenran.bsky.social · 16/04/2025Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS: www.sciencedirect.com/science/arti...sciencedirect.comInteroceptive processing in the nucleus of the solitary tractThe interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph… 05519
Reposted by Ye LabArdem Patapoutian @ardemp.bskyverified.social · 06/03/2025Great collaboration with @liye-tsri.bsky.social @dlipomi.bsky.social, and Jonathan Long labs and led by Yu Wang and Yunxiao Zhang 2/2 041