Neuroinflammation drives neurodegeneration and cognitive decline in aging, but the signals that spread this inflammation across the CNS remain unclear. Here, we show in mice that advanced age and expe...

Dayanne Carvalho is a Chemistry PhD student at Stanford and part of the Chemistry/Biology Interface (CBI) Training Program at Sarafan ChEM-H

Tumor-selective ENPP1 inhibitor is highly sought after for cancer immunotherapy to activate anti-cancer innate immunity without systemic inflammation. Wang et al. achieved this with STF-1623, which ha...

Researchers have discovered a highly conserved post translational modification in the STING pathway that when inhibited stops its activity

Palmitoylation at C64 in stimulator of interferon genes (STING) is reported and, along with engagement of C91, is involved in dynamic cross talk with C148 to alter STING oligomer states and ultimately...

Stanford biochemist Lingyin Li’s lab is studying a tumor-fighting “miracle molecule” that could one day inform therapies for cancer, as well as autoimmune, neurodegenerative, and age-related diseases.

Only one in five patients is estimated to respond to immune checkpoint inhibitors, which primarily target adaptive immunity. To date, no FDA-approved immunotherapies directly activate the innate anti-...

Arc Institute is a independent nonprofit research organization headquartered in Palo Alto, California.