Cell-type deconvolution methods are often needed to analyse spatial transcriptomic data to recover cell-type distributions. In this Review, the authors describe the process of cell-type deconvolution,...

Nature Reviews Genetics, Published online: 14 May 2025; doi:10.1038/s41576-025-00845-yCell-type deconvolution methods are often needed to analyse spatial transcriptomic data to recover cell-type distributions. In this Review, the authors describe the process of cell-type deconvolution, contrast the tools available and highlight important considerations for which tool to use.

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