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Leo Otsuki

@leootsuki.bsky.social
868 followers 400 following 70 posts

Group leader at the Hubrecht Institute, fascinated by tissue regeneration. Studies the axolotl, a vertebrate capable of regenerating entire limbs after injury, and uses the principles learnt to build 3D tissues in vitro. 🇳🇱🇦🇹🇬🇧🇯🇵

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Leo Otsuki @leootsuki.bsky.social · 26/08/2026
Congratulations Anahi and everyone! Looks beautiful.
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canaztekin.bsky.social @canaztekin.bsky.social · 21/10/2025
🔬 Limb regeneration depends on regenerative signaling center cells — but how do these cells influence others to proliferate, migrate, or differentiate? We’re recruiting PhD or Postdoc candidates to explore this with our collaborator @osvaldo-chara.bsky.social !
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Hubrecht Institute @hubrechtinstitute.bsky.social · 26/09/2025
Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! f.mtr.cool/jncxfqkuds
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Leo Otsuki @leootsuki.bsky.social · 28/07/2025
Thank you very much, Osvaldo!
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Leo Otsuki @leootsuki.bsky.social · 28/07/2025
Thank you! I cannot wait to get started.
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Leo Otsuki @leootsuki.bsky.social · 26/07/2025
Thank you, Yan!
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thanks, Çağrı!
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thank you, Yasin! You are always so kind. I wish you all the best in your new home too.
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thanks, Sanjay! I wish you also exciting next steps!
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thank you, Amro!
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thank you very much, Diana!
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thank you, Josh. Looking forward to crossing paths again!
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thanks very much, Neha!
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thank you, Filipa - you are always so kind! I'm looking forward.
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Thank you, Osvaldo. You've always been an amazing source of support and encouragements. I can't wait to pop over and see you - I'm sure Aida and I can arrange something :)
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Leo Otsuki @leootsuki.bsky.social · 25/07/2025
Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute! 🔗 www.hubrecht.eu/research-gro... We study how tissues regenerate - and use those principles to build 3D tissues in vitro. Full announcement: www.linkedin.com/in/leo-otsuk... @hubrechtinstitute.bsky.social
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Hubrecht Institute @hubrechtinstitute.bsky.social · 10/07/2025
🧬 Looking for a PhD position in molecular or developmental biology? 🔬 ✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
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Leo Otsuki @leootsuki.bsky.social · 03/07/2025
Thank you very much 😊🎉
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Leo Otsuki @leootsuki.bsky.social · 03/07/2025
Thank you, Aniek :)
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Leo Otsuki @leootsuki.bsky.social · 02/07/2025
I highly recommend signing up for this! I found it so informative and constructive. I owe a lot to Sumru and Mekayla, from answering my super-naive questions to advising on my proposal and setup last year. Thanks so much, you are treasures of the regeneration community!
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Leo Otsuki @leootsuki.bsky.social · 16/06/2025
A (little bit) more info here: www.linkedin.com/feed/update/...
linkedin.com
Salamanders normally regenerate only the missing part of the arm after an injury - e.g. | Leo Otsuki
Salamanders normally regenerate only the missing part of the arm after an injury - e.g. a wrist-level injury only regenerates a hand. But if they receive retinoic acid (RA), this control is overridden...
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Leo Otsuki @leootsuki.bsky.social · 16/06/2025
Precise degradation of Retinoic acid (RA) determines which part of the limb a salamander regenerates. Congratulations to the team, expertly led by Tim Duerr in James Monaghan's group:
nature.com
Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration - Nature Communications
How axolotl salamanders know what portion of the limb to regenerate remains a mystery. In this article, the authors show that precise retinoic acid degradation is critical for instructing…
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Leo Otsuki @leootsuki.bsky.social · 09/06/2025
This raises exciting questions about the molecular and physical requirements for re-building each part of the limb. Congratulations to all the authors @jamesmonaghan.bsky.social lab on a beautiful study!
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Leo Otsuki @leootsuki.bsky.social · 09/06/2025
Similar to whole-limb regeneration, nerves are essential for the digits to regenerate. Amazingly, the authors found that the second finger regenerates more accurately than the others (why?) - but apparently not due to the degree of nerve innervation or differences in classical limb patterning genes.
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Leo Otsuki @leootsuki.bsky.social · 09/06/2025
Axolotls accurately regenerate their limbs but frequently make mistakes during finger regeneration, which surprises me given their apparently simple structure. This study, led by Jackson Griffiths from James Monaghan's lab, dives deep into this fascinating paradox. www.biorxiv.org/content/10.1....
biorxiv.org
A Characterization of Axolotl Digit Regeneration: Conserved Mechanisms, Divergent Patterning, and a Critical Role for Hedgehog Signaling
Axolotl digits offer an experimentally versatile model for studying complex tissue regeneration. Here, we provide a comprehensive morphological and molecular characterization of digit regeneration,…
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Tatiana Sandoval Guzmán @tatianasg.bsky.social · 27/05/2025
We are really grateful and honored for this comment on our latest preprint! AND we share the spotlight with the Monaghan lab! Thanks @woutermasselink.bsky.social and @dev-journal.bsky.social
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Leo Otsuki @leootsuki.bsky.social · 27/05/2025
Yes - dream team! Congratulations to all of you on this beautiful synergy 👏
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Leo Otsuki @leootsuki.bsky.social · 26/05/2025
Congratulations, Anna!!
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Jeroen Bakkers @bakkerslab.bsky.social · 23/05/2025
We are hiring a new PhD student in #Bioinformatics and Organ #Regeneration using to join our team at the @hubrechtinstitute.bsky.social If you are interested in how the heart regenerates and want to work in a dynamic and experienced team please apply here. www.hubrecht.eu/job/phd-stud...
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thanks very much, Andras! Hope to cross paths soon. 😊
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you!
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thanks very much, Anna!
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you, Rita! 😊
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you, that’s very kind 😊
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you, Alex 😊
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you, Josh!
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you very much!
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you! I also cannot wait for our next adventures together!
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you, Osvaldo. You are so kind to us 😊
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you Tatiana, and always for your support 😊
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Leo Otsuki @leootsuki.bsky.social · 23/05/2025
Thank you! That’s very kind of you 😊
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Leo Otsuki @leootsuki.bsky.social · 22/05/2025
Thank you!!
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Leo Otsuki @leootsuki.bsky.social · 22/05/2025
Thank you very much!
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Leo Otsuki @leootsuki.bsky.social · 22/05/2025
Thank you very much, Osvaldo- supported by an amazing team!
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Leo Otsuki @leootsuki.bsky.social · 21/05/2025
Thank you - that's very kind of you. Glad you enjoyed!
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Leo Otsuki @leootsuki.bsky.social · 21/05/2025
Thank you, Prayag!
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Leo Otsuki @leootsuki.bsky.social · 21/05/2025
Thank you Elado!!
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Leo Otsuki @leootsuki.bsky.social · 21/05/2025
Thank you, Filipa! Hope to see you again soon at conference.
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Leo Otsuki @leootsuki.bsky.social · 21/05/2025
Thank you very much, Francesca!
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Leo Otsuki @leootsuki.bsky.social · 21/05/2025
Thank you very much, Çağrı!
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