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Lena Amend

@lenaamend.bsky.social
106 followers 169 following 1 posts

Microbiome researcher, host-microbe interactions, bacterial cross-feeding 🧫 Postdoc at University Würzburg

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Reposted by Lena Amend
Helmholtz Institute Würzburg @helmholtz-hiri.bsky.social · 05/05/2026
Yay! Hoda Kooshapour, #PhD student in the @westermannlab.bsky.social, has received a Paper of the Month Award from the @helmholtzhzi.bsky.social. Congratulations, @kooshapour.bsky.social! 🥳👏 Learn more: www.helmholtz-hiri.de/en/newsroom/... (1/3)
helmholtz-hiri.de
Mapping hidden RNA regulators in Salmonella infection
HZI Paper of the Month Award for Hoda Kooshapour
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Reposted by Lena Amend
Westermann Lab @westermannlab.bsky.social · 27/03/2026
Takeshi Kanda represented our team at the Japanese Society for Bacteriology conference, founded by Prof. Dr. Shibasaburo Kitasato - one of Japan's oldest societies. He also took the opportunity to connect with several Würzburg alumni.
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Reposted by Lena Amend
Oleg Dmytrenko @olehdmy.bsky.social · 07/01/2026
Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...
nature.com
RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - Nature
Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arres...
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Reposted by Lena Amend
Westermann Lab @westermannlab.bsky.social · 25/09/2025
Congrats to Ann-Sophie Rüttiger who successfully defended her PhD this week! 🎓 She focused on global RNA-binding proteins in Bacteroides—bacteria lacking Hfq, ProQ, CsrA, Khp—culminating in the discovery of a post-transcriptional network governed by RbpB (www.nature.com/articles/s41467-024-55383-8).
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Reposted by Lena Amend
Westermann Lab @westermannlab.bsky.social · 17/08/2025
Latest preprint from the lab: doi.org/10.1101/2025... In this study lead by @lenaamend.bsky.social from the group, we explore carbon cross-feeding between a gut commensal and an enteropathogen. Can we counter infection by cutting sugar supply to pathogens?
doi.org
Ablation of polysaccharide breakdown in Bacteroides thetaiotaomicron prevents cross-feeding and growth of Salmonella Typhimurium in the mouse gut
Pathogens invading the intestine compete for nutrients with the resident microbiota. However, there is evidence that commensal members of the gut also provide nutritional resources to enteropathogens ...
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Reposted by Lena Amend
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 09/08/2025
Ablation of polysaccharide breakdown in Bacteroides thetaiotaomicron prevents cross-feeding and growth of Salmonella Typhimurium in the mouse gut www.biorxiv.org/content/10.1101/202…
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Reposted by Lena Amend
Westermann Lab @westermannlab.bsky.social · 08/07/2025
Very honored that our recent study on Bacteroides morphotypes was spotlighted 🔦 in Trends in Microbiology by Eric Martens & Qinnan Yang: www.cell.com/trends/micro....
cell.com
Low biomass bacterial transcriptomics takes shape
Bornet et al. apply a low-input bacterial RNA-seq pipeline to transcriptionally profile small, medium, and large cell populations of the human gut symbiont Bacteroides thetaiotaomicron separated by fl...
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Reposted by Lena Amend
Westermann Lab @westermannlab.bsky.social · 17/06/2025
Our latest: www.cell.com/cell-reports/fulltext/S2211-1247(25)00615-1. Links Bacteroides cell size w/ gene expression. Protocol works even for single cells. 🦠 Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
cell.com
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Bornet et al. investigate the morphological heterogeneity of Bacteroides thetaiotaomicron cells observed both in laboratory culture and inside the mammalian GI tract. The authors show that cell size i...
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Reposted by Lena Amend
Westermann Lab @westermannlab.bsky.social · 10/04/2025
Some say, important sRNAs can be recognized by having their own “sponge” 🧽. Well, here comes InvS: a sponge of PinT (and vice versa). Congrats to @kooshapour.bsky.social and @ginlaca.bsky.social on their great work! doi.org/10.1101/2025...
doi.org
Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT
Salmonella virulence chiefly relies upon two major pathogenicity islands, SPI-1 and SPI-2, which enable host cell invasion and intracellular survival, respectively. There has been increasing evidence ...
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Reposted by Lena Amend
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 08/04/2025
Intramacrophage RIL-seq uncovers an RNA antagonist of the Salmonella virulence-associated small RNA PinT www.biorxiv.org/content/10.1101/202…
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Lena Amend @lenaamend.bsky.social · 01/03/2025
Honored to have been one of the selected scholarship awardees at the Keystone Symposium on the Human Microbiome in February 2025 in Banff, Canada. I had an amazing time! #KSHumanMicro25 #KSHostMicrobe25 #keystonesymposia
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Reposted by Lena Amend
Keystone Symposia @keystonesymposia.bsky.social · 21/02/2025
Exciting developments from Banff, Canada, as we celebrate our award recipients at the joint meeting on Human Microbiome and Host-Microbe Co-Evolution in Human Health. Join us in applauding these exceptional scholarship winners! #KSHumanMicro25 #KSHostMicrobe25 #keystonesymposia
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