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Leah Houri-Zeevi

@leahhouri.bsky.social
1.4K followers 1.4K following 99 posts

Simons Junior Fellow | EMBO | @Vosshall lab, Rockefeller University | A molecular biologist mixing genetics, evolution, neurobiology, and pathogens

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Leah Houri-Zeevi @leahhouri.bsky.social · 07/10/2026
I always wondered if there's such a person!
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Reposted by Leah Houri-Zeevi
Rob Waterhouse @rmwaterhouse.bsky.social · 30/09/2026
The ubiquity of insect-vertebrate interactions makes clear that widespread #insect #declines are likely to seriously affect many vertebrate populations www.nature.com/articles/s44... #biodiversity #ecology #InsectDecline
nature.com
The importance of insect biodiversity for vertebrates - Nature Reviews Biodiversity
Changes in insect diversity and abundance can affect vertebrates but understanding these consequences relies on having rich information about vertebrate–insect interactions. This Review summarizes the...
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Leah Houri-Zeevi @leahhouri.bsky.social · 29/09/2026
Congratulations!!!!! It's amazing that you got it to work + I can't wait to hear all the crazy neuroscience that will follow
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Reposted by Leah Houri-Zeevi
Maya Voichek @mayavoichek.bsky.social · 24/09/2026
Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)
AI-generated illustration of the soma-to-germline transmission of retrotransposons described in our work
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Leah Houri-Zeevi @leahhouri.bsky.social · 27/09/2026
c) True! We mentioned it in the discussion and it requires more work to understand the full effect re-expressions of hbf might have on the severeness of malaria. Awesome questions, thank you!
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Leah Houri-Zeevi @leahhouri.bsky.social · 27/09/2026
a) isoleucine is one of the essential AA in Plasmodium and across many animals, including mosquitoes and humans. None of them have the biosynthetic pathways to make it. b) yes :) but we left it out of the paper because we didn’t have the same nested control as with the non biting mosquitoes.
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Leah Houri-Zeevi @leahhouri.bsky.social · 27/09/2026
Thanks a lot Navin!
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Leah Houri-Zeevi @leahhouri.bsky.social · 27/09/2026
Thank you!!!
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Leah Houri-Zeevi @leahhouri.bsky.social · 27/09/2026
Thanks Jeff!!
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
THANK YOU 🤩
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Thanks a lot Jeffrey!
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
@erichjarvis.bsky.social @marakat.bsky.social Paolo Gabrieli, and to the absolute rockstar of a mentor and scientist @leslievosshall.bsky.social to which I'm grateful beyond words 🙏🙏🙏🙏🙏
static.klipy.com
Hyped Baby Fan Cheering
ALT: Hyped Baby Fan Cheering
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Jen Balacco and the @vertebrategenomes.bsky.social @nadavshai.bsky.social @amakunin.bsky.social Umberto Palatini, Dr. Toma and Dr. Okazawa, Chris Stone, Anita Schiller, Olivier Fedrigo
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
This was a HUGE multi-year TEAM effort across three continents and outstanding collaborations which made this entire journey possible and FUN. I'm so grateful to each and every one of you @pbrand.bsky.social @ire95.bsky.social, Allie Defoe (❤️)
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Together this gives a compact set of genes, cell types, and brain regions associated with a complex and medically devastating trait, and an evolutionary entry point for dissecting it. We would LOVE to hear your thoughts, criticism, questions, and truly any impressions.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
One species sits mid-transition: Wyeomyia smithii blood feeds in some populations and not others. It retains most blood-feeding genes but ALREADY has a contracted odorant receptor repertoire and reduced antennal lobes. A snapshot of a complex trait coming apart?
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
And it goes all the way to the brain. Using synchrotron microtomography we found the antennal lobes, the primary olfactory centers, are significantly smaller in non-blood-feeding females: peripheral receptor loss mirrored by shrinkage of the circuits that process their input
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
THE ODORANT RECEPTOR REPERTOIRE OF NON FEEDERS IS CONTRACTED. Even better: the lost odorant receptors aren't random. They define a discrete population of antennal neurons that is strongly female-biased. Exactly the cells you'd want if your job is finding a host
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
The losses reach the senses too. Non-feeders lost odorant binding proteins and two ionotropic receptor clades that were previously shown to sit in the female stylet and respond to blood: the taste of blood itself (more here: pmc.ncbi.nlm.nih.gov/articles/PMC...)
pmc.ncbi.nlm.nih.gov
Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes
Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each me...
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Plus the ones nobody expected: an apolipoprotein-domain salivary protein, an ABC transporter, a CLIP-domain serine protease, and a carboxylesterase expressed in the female fat body and brain glia. New candidates, straight out of convergent loss.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Using these, we discovered a set of genes convergently lost in non-feeders that reads like a recipe for biting! Aegyptin, a salivary protein that blocks platelet aggregation. Blood-activated gut proteases that digest the meal and are upregulated 2000X fold after the female eats blood
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
We built chromosome-level genomes for seven species spanning all three non-blood-feeding lineages and blood-feeding relatives, plus whole-brain tomographic reconstructions. Key control: Sabethes cyaneus genome from the group of @marakat.bsky.social a BLOOD FEEDER sitting right among the non-feeders.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
So we went and got all three. Toxorhynchites from a colony that was used a biological control for other mosquitoes in Texas, and we field collected Topomyia and Malaya in Okinawa, together with the legendary Dr. Ichiro Miyagi and his Mosquito Team!
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Blood feeding is ancestral to mosquitoes and has been maintained for ~200 million years. But three lineages - Toxorhynchites, Topomyia, and Malaya - independently abandoned it. And that's ALL of them: every mosquito lineage known to have ever given up blood.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Which makes it very hard to study. A trait spread across dozens of genes and several tissues can't be taken apart one gene at a time, and knocking out single genes rarely gives you the full picture. So instead of breaking it ourselves, we looked for evolution doing it for us.
static.klipy.com
Jim Carrey as Dr. Robotnik: It's Evolution!
ALT: Jim Carrey as Dr. Robotnik: It's Evolution!
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Blood feeding is an enormously complex trait. To bite you, a female has to find you across a room, land, puncture your skin, stop your blood from clotting, and then digest a meal heavier than her own body and turn it into eggs. It takes most of the animal to pull off.
static.klipy.com
Mosquito Feeding: Close-Up of a Bite
ALT: Mosquito Feeding: Close-Up of a Bite
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Tl;dr: three mosquito lineages independently QUIT feeding on blood. We created reference genomes and scanned the brains of all of them and used what they lost to find the genes, neurons, and brain regions associated with blood feeding
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
1. Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes www.biorxiv.org/content/10.6...
biorxiv.org
Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes
Complex traits that span multiple tissues and systems often integrate large numbers of genes across development, physiology, and behavior, making it challenging to identify their essential components....
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
I'm grateful to our incredible collaborators, the great advice we received from colleagues, and to the one and only, the amazing @leslievosshall.bsky.social for a very wild scientific ride
static.klipy.com
Simon Cowell Says So Amazing
ALT: Simon Cowell Says So Amazing
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
There are multiple scientific and medical implications for these findings, and a lot more detail. I encourage you to read the Discussion (and the whole paper really). We would LOVE to hear your thoughts, criticism, questions, and truly any impressions.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
If we are right, Plasmodium should grow well on our FETAL hemoglobin, without any isoleucine dependency (long scientific history here, details in paper!) We tested it together with Martin Kampmann and Manoj Duraisingh @ Harvard School of Public Health. The answer is a striking YES.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
The missing link: blood parasites. Malaria parasites (Plasmodium) EAT hemoglobin as their main food and arrest development without external isoleucine. We hypothesized that isoleucine-less adult hemoglobin protects against such blood parasites, by depriving them this critical amino acid.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Several mammalian species and lineages keep all adult subunits at strict ZERO. Including multiple bats, and all the primates, except for the ones that live in Madagascar. In ALL of them, the adults are at strict zero, but the embryonic/fetal have normal levels.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
To answer that, we started by analyzing 707 vertebrate genomes and pulled the hemoglobin proteins from each to quantify isoleucine levels across the different species. We found that isoleucine levels in the major alpha and beta subunits dropped specifically in mammals
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
But wait… why doesn't hemoglobin have isoleucine? It's a 70-year-old biochemical fact, but is really a statistical anomaly with a chance of ~3 in a million. What's more, all 3 adult hemoglobin subunits lack isoleucine completely, but the fetal and embryonic ones have normal levels. What is going on?
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
When you have a limited supply, you need to budget: we also found that the super highly expressed proteins that digest the precious blood meal in the gut barely use isoleucine, and some of them not use it at all (compared to ~5% genomic average!)
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
We found that blood feeding mosquitoes use significantly less isoleucine across their entire proteome, compared to mosquitoes that stopped feeding on blood
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Mosquitoes fed on blood for ~200 million years, but blood can be a limited nutrient: adult human hemoglobin COMPLETELY LACKS any isoleucine residues, depriving mosquitoes from this essential amino acid.
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Amino acids are not just codes, they are also nutritional building blocks often acquired from the environment. In microbes, the scarcity of an amino acid can shape which isoforms of highly expressed proteins will be activated, and even their entire protein composition. Could animals do that too?
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
Tl;dr: Mosquito proteomes match the proteins in our blood, and we suggest that your hemoglobin has no isoleucine as a defense against the very parasites mosquitoes carry
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
2. Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth www.biorxiv.org/content/10.6...
biorxiv.org
Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth
Amino acid composition within a proteome is conventionally viewed as a property of individual protein function. However, specific nutrient scarcity has been shown to reshape which amino acids are enco...
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Leah Houri-Zeevi @leahhouri.bsky.social · 25/09/2026
🩸🩸🩸TODAY WE SHARE TWO MAJOR DISCOVERIES🩸🩸🩸 1. We peered into genomes and brains of the rare mosquitoes that QUIT feeding on blood and found what biting is built from 2. Humans got rid of isoleucine in their blood, malaria suffers from it, and mosquito proteomes budget for it THREADS>
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Reposted by Leah Houri-Zeevi
Cedric Feschotte @cedricfeschotte.bsky.social · 24/09/2026
Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/n
science.org
Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates
Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...
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Leah Houri-Zeevi @leahhouri.bsky.social · 02/09/2026
וואו שי, בהצלחה רבה ושיהיה מעבר מוצלח ומשמח!
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Reposted by Leah Houri-Zeevi
The Transmitter @thetransmitter.bsky.social · 26/08/2026
“All men by nature desire to know” is the first line of Aristotle’s seminal work “Metaphysics.” New findings show that this statement extends across the animal kingdom to mice, too. #neuroskyence By @sarahthau.bsky.social www.thetransmitter.org/behavior/wou...
thetransmitter.org
Wouldn’t you like to know? A mouse would
Mice seek information for curiosity’s sake—and their desire for knowledge versus a payout is represented distinctly in the brain, new findings suggest.
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Leah Houri-Zeevi @leahhouri.bsky.social · 21/04/2026
Intickourse
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Leah Houri-Zeevi @leahhouri.bsky.social · 13/03/2026
Thrilled to finally see this work out! Congrats to everyone involved 🪱🧪✨
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Reposted by Leah Houri-Zeevi
Philipp Brand @pbrand.bsky.social · 27/02/2026
@annaryba.bsky.social's paper on the neural underpinnings of intraspecific behavioral variation is now out in @currentbiology.bsky.social Highly recommend! -> Paper identifies neural substrate for variation in promiscuity among Drosophila melanogaster strains🧪 www.sciencedirect.com/science/arti...
sciencedirect.com
Strain variation identifies a neural substrate for behavioral evolution in Drosophila
Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral res…
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Leah Houri-Zeevi @leahhouri.bsky.social · 01/02/2026
Links? :)
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Leah Houri-Zeevi @leahhouri.bsky.social · 23/12/2025
I missed this before - thank you!!!
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