Weakening of synaptic inhibition in the spinal dorsal horn (SDH) contributes to mechanical allodynia after peripheral nerve pathology. Restoring inhibition can alleviate allodynia, whereas weakening i...

Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

Adaptation is a common neural phenomenon wherein sustained stimulation evokes fewer action potentials (spikes) over time. Rather than simply reduce firing rate, adaptation may help neurons form better...

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Loss of GABAergic and glycinergic inhibitory efficacy in the spinal dorsal horn is associated with neuropathic pain and opioid-induced hyperalgesia in rodent models. Downregulation of the KCC2 chlorid...

As many as two billion people suffer from it — including me. Can science finally bring us relief?

Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-threshold mechanoreceptors (LTMRs) in the rodent glabrous skin has received sc...