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Laura Alder, MD

@lauraaldermd.bsky.social
524 followers 82 following 18 posts

Thoracic Medical Oncologist @DukeCancer. Asst Prof @DukeMedicine. Deputy Director Duke Center for Brain and Spine Mets. Passionate about #LCSM 🫁🎯🧬, clinical trials, PROs, #MedEd

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Reposted by Laura Alder, MD
IASLC @iaslc.bsky.social · 25/03/2025
Did you catch the most recent episode of #LungCancerConsidered? @narjustflorezmd.bsky.social & @lauraaldermd.bsky.social dive into lung cancer & brain metastases—why MRI surveillance matters, how to time radiation & balancing risks like radiation necrosis. 🎧 Listen now: bit.ly/TTLC25LC-BM
bit.ly
Live from TTLC25: Lung Cancer and Brain Metastasis | IASLC
In this episode of Lung Cancer Considered, host Dr. Narjust Florez discusses lung cancer and brain metastasis with Dr. Laura Alder.
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Reposted by Laura Alder, MD
Narjust Florez, MD, FASCO @narjustflorezmd.bsky.social · 22/03/2025
Mentorship meeting with Dr. @LauraAlderMD in Miami… I can get used to this Aims 1, 2, and 3 drafted Up to next ! 2025 @precisca Fellows Retreat
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Reposted by Laura Alder, MD
Duke Center for Brain and Spine Metastasis @dukemets.bsky.social · 12/03/2025
Check out the ABC11 interview with @lauraaldermd.bsky.social, our Deputy Medical Director, about lung cancer, new treatments, and the Duke Center for Brain and Spine Metastasis. (Her interview starts at the 4-minute mark!) abc11.com/post/abc11-t...
abc11.com
ABC11 Together Perspectives for March: Durham Crop Hunger Walk and Walk to Defeat Dementia
ABC11 Together Perspectives for March includes fundraiser for lung cancer research
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Laura Alder, MD @lauraaldermd.bsky.social · 12/03/2025
Honored to discuss lung cancer with ABC11 highlighting screening, self-advocacy, destigmatization, and the crucial impact of research on cancer treatments resulting in improved QoL and outcomes. @dukecancer.bsky.social #LCSM #LungCancer #CancerResearch #OncSky muckrack.com/broadcast/sa...
muckrack.com
Muck Rack | For journalists and public relations
Use Muck Rack to find journalists, get press for your story, monitor the news and report on the impact of your PR. Journalists can build portfolios and accelerate their careers.
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Reposted by Laura Alder, MD
The Lancet @thelancet.com · 07/02/2025
“...to care is an act not of weakness, but of strength.” The Lancet response: bit.ly/4jRb5Av
A Lancet Editorial: “American chaos: standing up for health and medicine”
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Laura Alder, MD @lauraaldermd.bsky.social · 14/01/2025
So honored, thankful, and excited to be a part of the 2025 IASLC Academy. Can’t wait to meet the cohort and the mentors, form new connections and collaborations, and learn from such stellar minds!! @iaslc.bsky.social #LCSM
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Laura Alder, MD @lauraaldermd.bsky.social · 08/01/2025
Always enjoy these JTO "Controversies in Thoracic Oncology!" This issue's relevant debate of including adjuvant IO after neo-adj chemo/IO raises great points, reviews current data, highlights the unknown. @drcamidge.bsky.social #LCSM www.jto.org/article/S155... www.jto.org/article/S155...
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Laura Alder, MD @lauraaldermd.bsky.social · 07/01/2025
Excellent review of lung neuroendocrine neoplasms by Dr Sen, @naglaakarimmd.bsky.social and team! Terrific discussion of molecular landscape, existing therapeutic challenges, and diagnosis & management strategies. #LCSM #LungNETs #SCLC @thelancet.bsky.social www.thelancet.com/journals/lan...
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Laura Alder, MD @lauraaldermd.bsky.social · 02/01/2025
Was happy to talk about the current status of NSCLC ADC's after WCLC24! Looking forward to more advances in 2025! #lcsm #oncsky
reachmd.com
Treating Second-Line NSCLC: The Efficacy of ADCs Targeting Predictive Biomarkers
The recent approval of antibody drug conjugates (ADCs) has the potential to address unmet needs associated with second-line treatment options for non-small cell lung cancer, like limited benefits and ...
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Laura Alder, MD @lauraaldermd.bsky.social · 02/01/2025
Important study and data in a patient group lacking strong next line options. Additionally notable with suggestion of CNS efficacy. Also looking forward to approval and additional data on promising Patritumab Deruxtecan (HER3-DXd) in such a setting
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Reposted by Laura Alder, MD
Oncology Brothers @oncbrothers.bsky.social · 28/12/2024
2024 approvals: Summary of 14 new drugs/indications in #LungCancer by FDA 1. #Tepotinib 2. #Osimertinib x2 3. #Alectinib 4. #Tarlatamab 5. #Zenocutuzumab 6. #Durvalumab x2 7. #Amivantamab x2 8. #Nivolumab (now SubQ) 9. #Ensartinib #lcsm #OncSky #MedSky #Cancer
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Reposted by Laura Alder, MD
Stephen Liu @stephenvliu.bsky.social · 17/12/2024
Details on uncommon #EGFR mutations @jtoonline.bsky.social. In 5212 #EGFR NSCLC dataset, 8.9% were uncommon mutations: associated with smoking history, higher rates of EGFR amp and TP53 co-mt, shorter time on TKI (4.1m) vs common (10.9m). #LCSM #OncSky www.jto.org/article/S155...
jto.org
Decoding the Clinical and Molecular Signatures of EGFR Common, Compound, and Uncommon Mutations in Non-Small Cell Lung Cancer.
Epidermal growth factor receptor (EGFR) mutations are key oncogenic drivers in lung adenocarcinoma (LUAD), predominantly affecting Asian, non-smoking, and female populations. While common mutations, such as exon 19 deletions and L858R, respond well to tyrosine kinase inhibitors (TKIs), uncommon EGFR mutations and compound variants exhibit variable treatment responses. This study aims to compare clinical characteristics and molecular profiles of patients with common, uncommon, and compound EGFR mutations, assessing their implications for therapy outcomes.
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Reposted by Laura Alder, MD
Stephen Liu @stephenvliu.bsky.social · 13/12/2024
Thoughtful commentary on perioperative immunotherapy for NSCLC from Drs. Tina Cascone and William William in Nature Reviews Clinical Oncology with their editorial on long-term data, durable benefit, and unanswered questions from the NADIM trial. #LCSM #OncSky www.nature.com/articles/s41...
nature.com
Perioperative nivolumab results in favourable long-term outcomes in patients with locally advanced resectable non-small-cell lung cancer - Nature Reviews Clinical Oncology
As one of the first studies testing perioperative anti-PD-(L)1 antibodies in resectable non-small-cell lung cancer (NSCLC), NADIM now confirms, in its final report, impressive 5-year clinical outcomes...
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Laura Alder, MD @lauraaldermd.bsky.social · 12/12/2024
So honored to be named Deputy Director of Duke Center for Brain and Spine Mets! CNS Mets in #lcsm is an area I’m passionate about, eager to collaborate with friends here #oncsky and continue to advance the field forward!! @dukemedschool.bsky.social @dukeneurosurgery.bsky.social
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Reposted by Laura Alder, MD
Nathan Pennell MD, PhD, FASCO @n8pennell.bsky.social · 08/12/2024
We have known for decade+ that you can detect progression using ctDNA months before you see it on scans. But until we show that it impacts outcomes to change tx earlier all it does is make ppl anxious and abandon treatments (TKIs) that may still be helping. Most MRD use today is marketing over data.
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Reposted by Laura Alder, MD
Stephen Liu @stephenvliu.bsky.social · 04/12/2024
Durvalumab now FDA approved for limited stage #SCLC based on the phase III ADRIATIC trial showing a PFS and an OS benefit (HR 0.73) with 2y of durvalumab after completion of definitive chemoradiation (avoid concurrent use). #LCSM #OncSky www.targetedonc.com/view/durvalu....
targetedonc.com
Durvalumab Wins FDA Approval in Limited-Stage Small Cell Lung Cancer
The approval of durvalumab, based on data from the phase 3 ADRIATIC study, offers a new standard of care for patients with limited-stage small cell lung cancer.
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Reposted by Laura Alder, MD
Giannis Mountzios MD @drgreeklungcancer.bsky.social · 01/12/2024
A must-read Review on the ever-evolving field of #EGFR mut #NSCLC in @natrevclinoncol.bsky.social highlighting: ➡️Strategies to improve on 1L 3rd Gen TKI mono therapy ➡️ Ways to tackle resistance post-Osi ➡️Perioperative landscape @LeXiuning @danieltanmd @RamalingamMD @IASLC #LCSM #some
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Reposted by Laura Alder, MD
Patrick Forde @patrickforde.bsky.social · 01/12/2024
Great summary in @Annals_Oncology of an intensive few days in March 2024 discuss the key issues confronting lung cancer care globally, thanks to Dr. @mayluciemeyer for her excellent leadership on this manuscript! #lcsm @IASLC @myESMO www.sciencedirect.com/science/arti...
sciencedirect.com
Lung cancer research and treatment: global perspectives and strategic calls to action
Lung cancer remains a critical public health issue, presenting multifaceted challenges in prevention, diagnosis, and treatment. This article aims to r…
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Reposted by Laura Alder, MD
David Tom Cooke, MD, FACS @davidcookemd.bsky.social · 29/11/2024
Surgical resectability for locally advanced #LungCancer redefined - Explore our expert consensus on who is eligible for curative #surgery in the age of #immunotherapy and targeted treatments. From STS #LCSM #SurgSky #MedSky #CancerSky www.annalsthoracicsurgery.org/article/S000...
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Laura Alder, MD @lauraaldermd.bsky.social · 27/11/2024
Intriguing paper utilizing unique DNA methylation signatures of LUAD brain metastases to predict risk and aid in noninvasive diagnosis via plasma. Many applications if prospectively validated: surveillance imaging timepoints, optimal treatment selection and timing. www.nature.com/articles/s41...
nature.com
Using tumor DNA methylomes to predict cancer metastasis to the brain - Nature Medicine
Metastatic spread of cancer to the brain has a devastating effect on patient outcomes, yet identifying patients who will develop brain metastases is difficult in current clinical practice. We show tha...
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Laura Alder, MD @lauraaldermd.bsky.social · 24/11/2024
Promising results in a patient population in huge need of improved treatment options and outcomes! Eager to see additional results #lcsm #oncsky
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Laura Alder, MD @lauraaldermd.bsky.social · 24/11/2024
76% 5 year OS, even with small numbers, represents such magnificent accomplishments in #LCSM! Taken with CROWN data (5 year PFS 60%, 92% pts free from intracranial progression!) helps cement Lorlatinib as clear 1st line choice for metastatic #lungcancer #oncsky @alkpositiveuk.bsky.social
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Laura Alder, MD @lauraaldermd.bsky.social · 22/11/2024
Honored to be interviewed about the rising incidence of lung cancer in non-smokers and especially females on @wral.bsky.social to shed light on #LCSM during #LungCancerAwarenessMonth and highlight the #HearHer campaign www.wral.com/lifestyle/he... @younglungcancer.bsky.social
wral.com
Rising lung cancer cases in nonsmoking women under 50: Experts urge awareness
An unexpected surge in lung cancer cases among nonsmoking women under 50 is raising alarms among oncologists, emphasizing the need for heightened awareness.
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Reposted by Laura Alder, MD
Gregory Riely @rielymd.bsky.social · 21/11/2024
Nice to see these guidelines on differentiating two primary lesions from metastatic disease in patients with NSCLC, an occasional diagnostic challenge. Big advance in past decade is using NGS www.jto.org/article/S155...
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Reposted by Laura Alder, MD
Jill Feldman @jillfeldman4.bsky.social · 21/11/2024
Working on the #ASCO #SCLC guidelines, published in 2023, was disheartening, but working on the rapid update (based on #ASCO24 data) left me emotional. This update represents hope & progress for patients who have waited far too long. ascopubs.org/doi/10.1200/... #LCSM
ascopubs.org
Systemic Therapy for Small Cell Lung Cancer: ASCO Guideline Rapid Recommendation Update | Journal of Clinical Oncology
ASCO Rapid Recommendation Updates highlight revisions to select ASCO guideline recommendations as a response to the emergence of new and practice-changing data. The rapid updates are supported by an e...
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Laura Alder, MD @lauraaldermd.bsky.social · 20/11/2024
Great analysis of DLL3 expression in SCLC and difficult to treat neuroendocrine neoplasms. Excited to see more biomarker driven approaches to advance care in such needed spaces. www.nature.com/articles/s41...
nature.com
Delta-like ligand 3 (DLL3) landscape in pulmonary and extra-pulmonary neuroendocrine neoplasms - npj Precision Oncology
npj Precision Oncology - Delta-like ligand 3 (DLL3) landscape in pulmonary and extra-pulmonary neuroendocrine neoplasms
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Reposted by Laura Alder, MD
Nathan Pennell MD, PhD, FASCO @n8pennell.bsky.social · 10/11/2024
I made a #LCSM list, small but growing! Not sure how to make it public? bsky.app/profile/did:... @jackwestmd.bsky.social @stephenvliu.bsky.social @pateloncology.bsky.social @tlblase.bsky.social @devikadasmd.bsky.social @jia-luo.bsky.social @garthnicholas.bsky.social
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