iiinova — where your digital self keeps evolving

Reposted by K. VijayRaghavan

K. VijayRaghavan @kvijayraghavan.bsky.social · 26/09/2026

I am in Delhi, visiting only thankfully, and walked into a library before dinner 10 minutes ago, and from the shelf picked a copy of the @lrb.co.uk I always read the letters first, hoping to find interesting humans who write interesting letters (most fume).

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K. VijayRaghavan @kvijayraghavan.bsky.social · 26/09/2026

….. and are getting in touch with John’s lab looking to collaborate.

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K. VijayRaghavan @kvijayraghavan.bsky.social · 26/09/2026

In the table of contents I saw John Tuthill’s name and was sure it was someone else with the same name, until I saw the letter . Was delighted to see it, very relevant to us as this (different types of motor innervation) is what we are now studying,

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K. VijayRaghavan @kvijayraghavan.bsky.social · 26/09/2026

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K. VijayRaghavan @kvijayraghavan.bsky.social · 24/12/2025

A very interesting tool with an unexpected finding from @krishnanyamuna.bsky.social and collaborators. Do read, enjoy, and use!

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Reposted by K. VijayRaghavan

Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

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Reposted by K. VijayRaghavan

Alfonso Martinez Arias @amartinezarias.bsky.social · 11/12/2025

Enjoying a visit @DBT_inStem & @ncbsbangalore.bsky.social Beautiful campus, great Science, amazing students Thank you @InamdarManeesha for the opportunity and @kvijayraghavan.bsky.social for a stimulating conversation

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Reposted by K. VijayRaghavan

Ishier Raote @ishier.bsky.social · 03/11/2025

#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST! We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease. Spread the word and join the discussion!

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K. VijayRaghavan @kvijayraghavan.bsky.social · 05/08/2025

Again, where exactly he used the term is a mystery for me now. While it can be attributed to my imagination, that is unlikely. I find it useful while discussing aspects of gene regulation.

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K. VijayRaghavan @kvijayraghavan.bsky.social · 05/08/2025

However, Brenner highlighted that a major unsolved problem (“the left-hand side”) was how genes, through complex regulatory processes, give rise to the intricate architectures, behaviours, and functions in multicellular organisms.

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K. VijayRaghavan @kvijayraghavan.bsky.social · 05/08/2025

This problem—how genetic information determines protein sequence—was solved mainly with the understanding of the genetic code and protein synthesis.

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K. VijayRaghavan @kvijayraghavan.bsky.social · 05/08/2025

In his Nobel Lecture, Brenner explained that early molecular biology (“the right-hand side”) focused on how the linear sequence of DNA specifies the linear sequence of amino acids in proteins.

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K. VijayRaghavan @kvijayraghavan.bsky.social · 05/08/2025

I read this—the“left-hand-side problem”—in a piece by Sydney Brenner. I can’t trace the piece or video now. I recollect that Brenner refers to the unresolved challenge of understanding how the cellular environment regulates genes to participate in creating the complex structures and functions.

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Reposted by K. VijayRaghavan

Mukund Thattai @thattai.bsky.social · 04/08/2025

I set out to review the evolution of eukaryotic intracellular traffic, but along the way a new hypothesis came into focus: maybe the earliest membrane carriers were tubules, not coated vesicles! New preprint: ecoevorxiv.org/repository/v... Here’s the idea. 🧵

A schematic showing two models for the evolution of the eukaryotic cell plan starting from an archaeal ancestor. The "inside-out" and "outside-in" models both lead to an intermediate stage with internal and plasma membranes connected by tubules. The sequence continues through the formation of an endomembrane lumen, followed by the emergence of membrane contact sites and tubular carriers, and finally coated vesicles and stable compartments.

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K. VijayRaghavan @kvijayraghavan.bsky.social · 31/12/2024

A very Happy 2025 to all here and outside.

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