Reposted by Kritika Kasliwal
Epigenetics Update - Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion go.nature.com/48ISkLD
UkJin Lee and @efapostolou29.bsky.social at @weillcornell.bsky.social
#Epigenetics #Chromatin
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epigenometech.com
go.nature.com
Postmitotic transcription and 3D regulation show locus-specific and differentiation-specific sensitivity to cohesin depletion - Nature Genetics
Lee et al. deplete the cohesin component RAD21 in mouse embryonic stem cells. Most but not all chromatin loops fail to reform after mitosis, and transcriptional changes were minor, except during diffe...
