Protein intake, physical activity, and skeletal muscle outcomes in middle-aged adults: an observational study from the US - Volume 15

Background Hospital-associated deconditioning is a contributor to secondary sarcopenia, which may be driven by prolonged hospital length of stay (LoS). This study investigated the bidirectional associ...

Background Testosterone declines by 0.4%–2% annually after the age of 30 and is potentially linked with muscle mass and strength. This study examined how testosterone levels are associated with hand...

AbstractBackground. Sarcopenia, the age-related loss of muscle mass and strength, poses a significant health and economic burden. This systematic review an

Dysregulated metabolomic profiles (dysmetabolism) have been observed in patients with heart failure (HF). In this study, we investigated metabolomic profiling differences in HF with reduced physical-f...

Background Sarcopenia, the age-related loss of skeletal muscle mass and function, has been linked to adverse health outcomes. Cross-sectional associations have been observed between skeletal and cardi...

Background Despite ongoing interest in anabolic therapies for sarcopenia and cachexia, pharmacological interventions are being developed to counteract age- and condition-related losses of muscle mas...

Horizontal bed rest (HBR) and head-down tilt (HDT) are models of physical inactivity. In this systematic review and meta-analysis, we aimed to quantify changes in cardiometabolic outcomes during HBR ...

Muscle disuse caused by bed rest and immobilization is associated with muscle atrophy and insulin resistance, which might be related to increases in intramuscular fat (IntraMAT) and intermuscular fat...

AbstractIntroduction. The global burden of heart failure (HF) is rising, with a shift towards more cases of heart failure with preserved ejection fraction

Sarcopenia, the age-related decline in skeletal muscle mass and strength, is a growing public health concern, yet several meta-analyses may be unreliable due to methodological and systemic challenges...

Probiotics, prebiotics, and synbiotics to counteract sarcopenia: where are we now and what challenges need to be faced?

Background Understanding the impact of food matrix, the combination of nutrients, bioactive compounds, and physical characteristics in a food product, on muscle protein synthesis (MPS), could provide ...

Muscle disuse leads to muscle atrophy and a decrease in muscle function that is primarily driven by reduced muscle protein synthesis (MPS). The aim of this systematic review and meta-analysis was to ...

Abstract figure legend This randomized controlled study investigated the effect of a 2 week treatment cycle of either oral clenbuterol or placebo in healthy young men. We found that clenbuterol: (1) ...

Frailty, often linked to sarcopenia, involves reduced muscle strength and mass. While sarcopenia has multiple causes, impaired muscle protein synthesis may contribute. Leucine and resistance training ...

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been pivotal for obesity treatment, achieving 15–25 % weight loss over 12–24 months, but qu…

Sarcopenic obesity, a subtype of obesity, is marked by reduced skeletal muscle mass and function, or sarcopenia, and poses a significant health challenge t

In this article, Parafati, Malany, and colleagues show that microgravity altered contractile response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS. Electrical stimulation en...

It has been suggested that different nutritional stimuli are required to augment myofibrillar versus muscle connective protein synthesis rates. To study such different aspects of skeletal muscle re...

Background Intermuscular (InterMAT) and intramuscular (IntraMAT) adipose tissues are key contributors to skeletal muscle function and metabolic health. Objective In this systematic review, we aimed to...

Introduction Sarcopenia is associated with the loss of skeletal muscle function and mass. Nicotinamide precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), have rece...

Introduction Sarcopenia is associated with the loss of skeletal muscle function and mass. Nicotinamide precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), have rece...

Malnutrition is associated with a higher odds of sarcopenia and their combined presence is a better predictor of all-cause mortality compared to sarcopenia alone, further highlighting the importance o...

This study evaluated whether dual-energy X-ray absorptiometry (DXA), computed tomography (CT), and magnetic resonance imaging (MRI) provide comparable outcomes in quantifying disuse-induced skeletal ...

Background Weight loss achieved via energy restriction leads to significant losses in muscle and bone mass, potentially increasing risk for sarcopenia and osteoporosis. High-intensity resistance and...

Metformin did not improve 4-m walk speed and was poorly tolerated in this population.

Muscle biopsies were taken from males and females differing in age and exercise habits. Mononucleated cells were isolated and purified into muscle stem cells (MuSC) and muscle fibroblasts (FIB). Neur....

Background Polypharmacy (concomitant prescription of ≥ 5 medications) affects a third of older people, and evidence suggests an association with sarcopenia (loss of skeletal muscle mass/quality, muscl...

Backgrounds A growing number of studies have shown that bariatric surgery can cause changes in the body composition of patients. This meta-analysis aims to reveal changes in skeletal muscle mass 1 yea...

Background Cancer cachexia presents a significant challenge, but the ghrelin agonist anamorelin shows promise as a potential treatment. This study examined whether the baseline systemic inflammatory.....

Cardiovascular events (CVEs) are the leading cause of death among hip fracture patients. Here, the authors show the findings on subphenotyping the heterogeneous spectrum of hip fracture patients in bo...

The addition of low-dose protein to low protein-containing meals in middle-to-older aged adults may promote greater postprandial plasma aminoacidemia and mitigate declines in muscle health but may be ...

Human skeletal muscle displays an epigenetic memory of resistance exercise induced-hypertrophy. It is unknown, however, whether high-intensity interval training (HIIT) also evokes an epigenetic muscle...

Background Obesity is a chronic disease associated with increased risk of multiple metabolic and mental health–related comorbidities. Recent advances in obesity pharmacotherapy, particularly with gl...