knoblich-lab.bsky.social @knoblich-lab.bsky.social · 06/10/2026This work has been pioneered by @vertesy.bsky.social, @ramseynajm.bsky.social and Bálint Doleschall, and wouldn't be possible without any any of the authors and the many people helping us on the way! 020
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 06/10/2026New preprint! 🧠🧬 Can cerebral organoids reveal intrinsic rules of circuit assembly? We think yes! COSCO maps >10,000 networks and reveals cell-type intrinsic wiring, reproducible network formation, recurrent motifs, molecular signatures of wiring and aberrant connectivity in TSC. bit.ly/47CryUl 2154
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 18/12/2025Come join us for an exciting opportunity in brain organoid research and human neurodevelopment! Applications close January 2026. More details below ⬇️ #organoids #neuroscience 040
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 18/12/2025Thank you to the Austrian Science Fund (FWF) for this tremendous opportunity. More information below 👇🏼 040
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 16/11/2025🎉 Congratulations to the newest PhD from the lab, Balint Doleschall! His work on combining scRNA sequencing and transsynaptic viral tracing techniques with barcoding will pave the way for dissecting neural circuits in human circuit development. An excellent achievement! #neuroscience #organoids 060
Reposted by @knoblich-lab.bsky.socialInstitute of Molecular Biotechnology @imbavienna.bsky.social · 16/10/2025🎉 Congratulations to Nina Corsini and Oliver Eichmüller, researchers in Jürgen Knoblich’s lab at IMBA, who were recognized with the German Tuberous Sclerosis Foundation’s Award for their research on tuberous sclerosis using cerebral organoids. More: imba.science/3Jej5hy 0112
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 08/10/2025Appreciate the article from @imbavienna.bsky.social and @impvienna.bsky.social for featuring our journey studying asymmetric cell division to cerebral #organoids 🙌 ⬇️ www.imp.ac.at/achievements...imp.ac.atJürgen Knoblich | Research Institute of Molecular PathologyJürgen Knoblich may be best known for his work on cerebral organoids at IMBA, but his nearly 30-year career in Vienna began at the IMP, where his group deciphered the molecular mechanisms of asymmetri... 090
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 07/10/2025Congratulations to postdoctorate Oguzhan Kaya! What a fantastic achievement 🎉🧠 #neuroscience #organoids 060
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 03/10/2025A huge congratulations to @saku-wong.bsky.social on this fantastic achievement! 🎉 0110
Reposted by @knoblich-lab.bsky.socialEmily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 02/06/2025"[W]e are more surprised by what organoids can do than what organoids can’t do." - @knoblich-lab.bsky.social Elie Dolgin explores the world of brain #organoids & #assembloids for @nature.com 🧪 www.nature.com/articles/d41...nature.comBrain tissues, assemble! Inside the push to build better brain modelsWith organoids, assembloids and a growing toolkit of bioengineering tricks, scientists are stitching together models of the developing human brain — and pushing the limits of realism and control. 121
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 29/08/2025Congrats to Hyosang Kim on receiving an EMBO Fellowship! 🧠 What an excellent achievement. 070
Reposted by @knoblich-lab.bsky.socialStylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 15/12/2024#NCB2024 In May, @knoblich-lab.bsky.social & co performed whole-tissue lineage tracing in human #cerebral #organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands. #CellBio2024 www.nature.com/articles/s41...nature.comCerebral organoids display dynamic clonal growth and tunable tissue replenishment - Nature Cell BiologyLindenhofer, Haendeler, Esk, Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage siz... 0295
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 19/11/2024All data is easily accessible in our Vienna brain organoid data explorer. You can look for your favorite gene or search for entire biological processes based on GO Terms. Check it out: vienna-brain-organoid-explorer.vbc.ac.at 000
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 19/11/2024We also provide RNA-seq data for cell lines in all protocols across organoid development. We quantify sources of variability (1. organoid developmental stage, 2. protocol, 3. cell line) and provide early signatures consistent with protocol-driven organoid derivation. 100
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 19/11/2024By comparison with fetal reference data, we can show that protocol-driven cells largely match cell types found in vivo while cell line-driven cells contribute to in vitro specific cell types. 100
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 19/11/2024Using scRNA-seq and a new measure for comparing scRNA-seq datasets from various sources, the NEST-score, we find protocol-driven cells (generated from many cell lines) as well as outlier, cell line-driven cells (generated from a single cell line only) for each protocol. 100
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 19/11/2024We characterized four regional brain organoid protocols across several cell lines using scRNA-seq on mature organoids and RNA-seq over time to generate a large fraction of human brain cells in vitro. 130
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 19/11/2024Find the article here: www.biorxiv.org/content/10.1... 100
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 19/11/2024Excited to share our latest preprint (@biorxivpreprint) on brain organoid development. Lead by Julia Naas and Meritxell Balmaña (@txellbalmana) with Arndt von Haeseler, Christopher Esk (@christopher-esk.bsky.social) and colleagues across Vienna. @maxperutzlabs.bsky.social, @IMBA_Vienna, @CeMM_News.biorxiv.orgReconstitution of Human Brain Cell Diversity in Organoids via Four ProtocolsHuman brain organoids are powerful in vitro models for brain development and disease. However, their variability can complicate use in biomedical research and drug discovery. Both the specific protoco... 1254
knoblich-lab.bsky.social @knoblich-lab.bsky.social · 19/11/2024We characterized four regional brain organoid protocols across several cell lines using scRNA-seq on mature organoids and RNA-seq over time to generate a large fraction of human brain cells in vitro. 000
