How do large-scale functional brain networks dynamically emerge to enable cognition? Correlated oscillations, a mechanism for inter-areal interactions, can be expressed as phase coherence or correlate...

Scientific Data - Dataset of cortical and subcortical single neuron activity during value-based tasks in macaque monkey

How humans process competing information when making multi-alternative decisions remains unclear. Here, the authors show that the brain resolves the trade-off between “evaluating within” and “comparin...

Epilepsy constitutes a clinically manifest excitability disorder that is characterized by aberrant electrophysiological activity in the electroencephalogram (EEG). The correct identification of the se...

Using intracranial electroencephalography from patients with epilepsy during spatial attention tasks, this study shows that high-frequency bursts facilitate fast communications in brain networks and s...

How do large-scale brain networks interact to enable cognition? Correlated oscillations, a mechanism for inter-areal interactions, can be expressed as phase coherence or amplitude co-fluctuations. Whi...

Working memory improves during adolescent brain development. Zhu et al. tracked monkeys through adolescence, revealing that maturation of white matter tracts and refinement of neural firing patterns s...

Using a new analytical method for tracking gamma band events in mouse visual cortex, flexible encoding of visual information according to behavioural context is shown.

A 1,024-channel microelectrode array is delivered to the brain cortex via a minimally invasive incision in the skull and dura, and allows recording, stimulation and neural decoding across large portions of the brain in porcine models and human neurosurgical patients.

Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.

Identifying single units from extracellularly recorded neural signals is critical for understanding brain circuit dynamics. With the advancements of large-scale recordings, efficient and precise autom...

While glutamatergic synaptic plasticity is believed to be a fundamental mechanism mediating learning, the behavioral significance of plasticity at cortical GABAergic synapses remains less well underst...

The reconstruction of whole-brain projectomes of 2,231 single neurons from the macaque prefrontal cortex reveals refined axon targeting and arborization, providing a structural foundation for primate-...

Null space theory predicts that neurons generate spikes not only to produce behavior but also to prevent the undesirable effect of other neurons on behavior. In this work, we show that this competitiv...

Cortical spiking activity in areas like prefrontal cortex (PFC) encodes information only along a small number of dimensions, a subspace of the full space of population activity patterns. PFC often use...

The latent circuit model identifies low-dimensional mechanisms of task execution from heterogenous neural responses. This approach reveals a latent inhibitory mechanism for context-dependent decisions...