iiinova — where your digital self keeps evolving

Reposted by Kenneth Chen

Jack Kucinski @jackkucinski.bsky.social · 23/07/2025

I’m happy to share our published work in @cp-cellreports.bsky.social! With zebrafish modeling of rhabdomyosarcoma, we showed that PAX3::FOXO1 utilizes homeobox motif recognition to initially bind closed DNA and activate neural programs present in the human disease. www.cell.com/cell-reports...

cell.com

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

Kucinski et al. use embryonic zebrafish modeling to understand initial chromatin regulatory mechanisms of fusion-driven pediatric rhabdomyosarcoma. They found that the PAX3::FOXO1 oncoprotein function...

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Kenneth Chen @kennethschen.bsky.social · 24/06/2025

Our study, led by Dr. Patricia Tiburcio, showed that blocking protein recycling may help fight anaplastic Wilms Tumor—a rare, aggressive childhood kidney cancer. Combining bortezomib with dactinomycin made tumors more sensitive to treatment in the lab. doi.org/10.1016/j.xc...

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Kenneth Chen @kennethschen.bsky.social · 23/04/2025

Congratulations to Claudette Fraire, Kavita Desai, Indumathy Jagadeeswaran, and others, for their work showing how microRNA loss drives a mouse model of a childhood cancer called pineoblastoma! @genesdev.bsky.social genesdev.cshlp.org/cgi/content/...

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Kenneth Chen @kennethschen.bsky.social · 03/04/2025

Nice work Sun, Josh, Tu, and others!

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Reposted by Kenneth Chen

American Association for Cancer Research (AACR) @theaacr.bsky.social · 02/04/2025

How can new approaches in early detection make a difference for pediatric cancers? In the new episode Believe in Progress podcast, we speak with Dr. Kris Ann P. Schultz, a pediatric oncologist, about how research is reshaping pediatric cancer care: www.youtube.com/playlist?lis...

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Kenneth Chen @kennethschen.bsky.social · 26/03/2025

This dashboard is great. Could you pin it to the top of your feed, or add the link to your profile?

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Reposted by Kenneth Chen

NPR @npr.org · 23/01/2025

An email obtained by NPR says NIH employees are subject to a travel freeze and offers of employment are being rescinded. Scientists worry about disruptions to critical research.

npr.org

National Institutes of Health cancels scientific meetings after Trump directives

An email obtained by NPR says NIH employees are subject to a travel freeze and offers of employment are being rescinded. Scientists worry about disruptions to critical research.

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Reposted by Kenneth Chen

Our World in Data @ourworldindata.org · 09/01/2025

Childhood cancer deaths in the United States have declined six-fold over the last seventy years

This chart presents US cancer death rates in children under five years old, measured in reported annual death rates per 100,000 children. It consists of four graphs:

1. All Malignant Cancers Combined: This graph, shown in black, illustrates a decline in childhood cancer death rates from about 11 per 100,000 in 1950 to around 1.8 in 2021, indicating a six-fold decrease since the 1950s.

2. Leukemia: This graph shows a decrease from around 5 per 100,000 in 1950 to less than 1 in 2021, following a similar declining trend throughout the decades.

3. Brain and Nervous System Cancers: This chart shows some fluctuations but overall a decline from nearly 0.8 per 100,000 in 1950 to about 0.4 in 2021.

4. Lymphomas and Multiple Myeloma: This graph shows fluctuations and a decline from around 0.8 in the late 1950s to less than 0.2 by 2021.

The data is sourced from the WHO Mortality Database (2024), with a note indicating that figures may fluctuate year-by-year due to low numbers.

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

This was a collaborative team effort! Thanks to Kavita Desai, Patricia Tiburcio, Austin Warne, and everyone else! Thanks also to funding from Pablove Foundation, Alex's Lemonade Stand, CPRIT, and NIH. And thanks to mentorship and support from @amatrudalab.bsky.social!

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

Or maybe we haven't been using the right therapy combinations. We've really only tried ICIs alone, but our data suggests that we should combine with conventional chemotherapy. In fact, we've opened a clinical trial to test that exact question! www.utsouthwestern.edu/newsroom/art...

utsouthwestern.edu

UT Southwestern, Children’s Health to lead clinical trial on pediatric cancer patients

UT Southwestern Medical Center will lead a national multicenter clinical trial to test a treatment strategy for pediatric cancer patients that has shown promising results in adults.

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

So: Why haven't childhood cancers responded to ICIs? Maybe we haven't been treating the right patients. The single-agent trials in pediatrics tested these drugs against all types of solid tumors. But we show that certain tumors are more immune-enriched.

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

Lastly, using public data from adult cancers, we showed that microRNA pathway alterations were linked to immune gene expression signatures and better response to ICIs.

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

The immune subset was also enriched for beta-catenin and microRNA pathway mutations. We verified that Wnt signaling induced PD-L1 expression in Wilms tumor cells. We also showed that knocking down DROSHA or DICER1 in Wilms tumor cells caused a robust increase in PD-L1.

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

Chemotherapy-treated tumors were in this immune subset. In public RNA-seq from an independent group of tumors, chemo exposure was also associated with immune gene expression. In the lab, we found that some chemotherapies, like doxorubicin, were particularly effective at inducing PD-L1.

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

We studied Wilms tumor, the most common childhood kidney cancer, which has low mutational burden. Using protein arrays, we were surprised to find that about a subset show upregulation of immune markers.

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Kenneth Chen @kennethschen.bsky.social · 04/12/2024

Why haven't childhood cancers respond to immune checkpoint inhibitors (ICIs) like adult cancers? New preprint from the lab! PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor www.biorxiv.org/content/10.1...

biorxiv.org

PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor

Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD...

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Reposted by Kenneth Chen

Olivier Saulnier @olivier-saulnier.bsky.social · 24/11/2024

Let's build a starter pack for childhood cancer research. Please send a message to be added! 🎗️ go.bsky.app/Tpd9QnM

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Reposted by Kenneth Chen

Josh Mendell @mendell-lab.bsky.social · 22/11/2024

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

science.org

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes

The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

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