Drug-associated sensory cues and contexts exert powerful influence over drug seeking motivation, but in vivo brain mechanisms governing this process remain unclear. Here, we recorded and manipulated d...

ALT: Shoot Gun

Nature Neuroscience - Senne, Suthard and colleagues show that dorsal hippocampal astrocytes display time-compressed calcium-event sequences after foot shock and upon context re-exposure, and that...

Neuropsychopharmacology - Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption

The Izquierdo Lab at UCLA studies the brain mechanisms of flexible reward learning and value-based decision making, with a focus on frontocortical circuits.

ALT: Philip J Fry's Shocked Reaction

A habit develops as a motivated behavior that is strengthened by extended experience and feedback. While the performance component of a habit is relatively well studied, being linked to action-related...

ALT: Donald Duck's Evil Smile

The mu opioid receptor system has long been recognized for its role in regulating ingestive behaviors and food palatability. However, beyond their rob…

Food intake is governed by two interacting drives. The homeostatic hunger drive regulates food intake to fulfill caloric needs while the hedonic drive promotes intake of palatable foods outside of cal...

Neuropsychopharmacology - Dorsal raphe nucleus enkephalin peptide modulates behavioral preference