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Kristina Micheva

@kdmicheva.bsky.social
901 followers 264 following 45 posts

Neuroscientist, array tomographist, learner of languages and martial arts

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Reposted by Kristina Micheva
Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 07/07/2026
Here are my slides for #fens2026 “A versatile and affordable array tomography workflow” jekelylab.codeberg.page/FENS_Array_… for the 'Expanding Horizons: Array Tomography in Neuroscience for All' […] [Original post on biologists.social]
ribbons of ultrathin sections in a scanning electron microscope, shown is a preview of the ribbons
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Kristina Micheva @kdmicheva.bsky.social · 06/07/2026
It was a great talk, with a bonus subject of software monopoly, in addition to the future of a more accessible volume EM!
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Reposted by Kristina Micheva
oZgun Gokce @gokcegroup.bsky.social · 06/07/2026
Istanbul: The Synapse of Continents hosts FRM2027! Where East meets West, we are excited to announce that the FENS Regional Meeting 2027 will take place in Istanbul from 26–29 May.
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Kristina Micheva @kdmicheva.bsky.social · 05/07/2026
First time at FENS Forum!
Welcome sign for the FENS Forum 2026 at the conference site, with the reflection of the photographer.
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Reposted by Kristina Micheva
Davi Bock @dddavi.bsky.social · 30/05/2026
Tend to agree. Work by us & @kdmicheva.bsky.social showed that a strangely high fraction (~50%) of myelin in upper layers of cortex wraps short lengths of fast-spiking, parvalbumin-positive basket cells. We suggested it was to support their axons, rather than to speed up spike time arrival.
elifesciences.org
A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons
Parvalbumin-positive inhibitory neurons in the cortex have insulating myelin sheathes, despite forming only short-range connections.
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Reposted by Kristina Micheva
Casey Schneider-Mizell @csdashm.com · 20/02/2026
From @bdpedigo.bsky.social: a super efficient, highly reliable, and very generalizable method for mesh structure classification, applied here to spine detection across basically every synapse onto a cell in the MICRoNS dataset.
Mesh analysis pipeline showing feature extraction and spine classification.
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Reposted by Kristina Micheva
Miriam B. Goodman, PhD @wormsense.bsky.social · 19/10/2025
It is with a heavy heart that I share the unexpected news that our colleague, friend, and mentor Daniel Madison passed away on Thursday, October 9.
Portrait of Dan V. Madison at an electrophysiology rig, overlayed on pairs of pyramidal neurons filled and reconstructed.
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Reposted by Kristina Micheva
Andrew Payne @andrewcpayne.bsky.social · 01/10/2025
E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. Read more: e11.bio/blog/prism
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Kristina Micheva @kdmicheva.bsky.social · 28/09/2025
Back from a trip and I found this unintentional present I left myself
A sprouted sweet potato puts a gorgeous display of delicate pinkish-purpelish stems and leaves
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Reposted by Kristina Micheva
Davi Bock @dddavi.bsky.social · 14/08/2025
It was a good experience to step back and briefly take stock of the amazing progress in connectomics since I started working on this stuff (20 years ago!) thanks as well to @natrevneuro.nature.com for the constructive editorial interactions.
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Kristina Micheva @kdmicheva.bsky.social · 12/08/2025
Ultramicrotomy escapism: trimming blocks and enjoying the shapes and colors 💕
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Kristina Micheva @kdmicheva.bsky.social · 01/08/2025
Our 2nd Array Tomography Workshop will be in November in Buenos Aires and there is still time to apply! Five days of hands-on learning, discussions and talks + gorgeous electron microscopy and immunofluorescence. Focus on simple and affordable workflows. www.arraytomography.org/workshop-202...
arraytomography.org
Workshop 2025
About the workshop This workshop will cover array tomography (AT) technology with a focus on “simple and affordable” workflows based on serial ultramicrotomy and imaging. The practicals include...
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Reposted by Kristina Micheva
Marine Biological Laboratory @mblscience.bsky.social · 28/07/2025
We're thrilled to announce the largest private gift in our 137-year history: a $25 million unrestricted donation from MBL Whitman Scientist Mark Terasaki. His extraordinary generosity will bolster our renowned research and education programs. 🔬 Learn more: bit.ly/452WL1m
bit.ly
MBL Announces Largest Ever Gift for Its Renowned Biological Education and Research Programs | Marine Biological Laboratory
Cell Biology Researcher Mark Terasaki’s $25 Million Unrestricted Gift Will Support Operations and Infrastructure Contact: Samantha Cummis scummis@mbl.edu; 973.800.4119
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Reposted by Kristina Micheva
Jemima Burden @jemimaburden.bsky.social · 03/07/2025
Excited to announce registration to the next Array Tomography workshop in Buenos Aires is now open! #volumeEM See our AT website page for more information ⬇ www.arraytomography.org/workshop-202...
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Reposted by Kristina Micheva
lyons-lab.bsky.social @lyons-lab.bsky.social · 14/05/2025
For those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...
nature.com
Activity-driven myelin sheath growth is mediated by mGluR5 - Nature Neuroscience
Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by signaling through metabotrop...
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Christophe 🔬 Leterrier @christlet.bsky.social · 31/01/2025
Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
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Reposted by Kristina Micheva
Kevin Mitchell @wiringthebrain.bsky.social · 20/01/2025
What happened to the pursuit of truth? rupress.org/jgp/article/... - Eve Marder, on point...
rupress.org
What happened to the pursuit of truth? | Journal of General Physiology | Rockefeller University Press
The knowledge in our brains, not in our phones, is necessary for creative thinking and the pursuit of truth.
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Kristina Micheva @kdmicheva.bsky.social · 18/12/2024
Happy to share a new biorxiv manuscript with @owen-lab.bsky.social where we “slice and dice” synapses with array tomography and find subclasses with different glutamate receptor composition 🧪
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Reposted by Kristina Micheva
Hanieh Falahati @haniehfalahati.bsky.social · 02/12/2024
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...
Gif showing a spine containing spine apparatus, reconstructed from FIB-SEM images. ER: red, synapse: yellow, plasma membrane: blue
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Reposted by Kristina Micheva
BWJones @bwjones.bsky.social · 28/11/2024
Layers Upon Layers bryanwjones.com/2020/06/laye... #SciArt #retina
A section of retina through the optic fiber layer, ganglion cell layer, inner plexiform layer, inner nuclear layer with amacrine and bipolar cells, the outer plexiform layer and the outer nuclear layers of retina.  This has been labeled with antibodies against small molecules to visualize the metabolism using Computational Molecular Phenotyping (CMP) strategies.
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Chris Rozell @crozell.bsky.social · 25/11/2024
Get a free NIH BRAIN Initiative art calendar to prep for 2025: catalog.ninds.nih.gov/publications... . I'm proud to say that the cover is a piece we created from the DTI imaging of a subject in the BRAIN funded depression DBS study we reported last year: go.nature.com/48lmlzC 🧪🧠
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Gord Fishell @gordfishell.bsky.social · 24/11/2024
Cortical interneurons learn on the job! Speculated this was true a decade ago! Sherry Wu and Min Dai finally provide evidence! www.biorxiv.org/content/10.1...
biorxiv.org
Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron subtypes
The mammalian cerebral cortex comprises a complex neuronal network that maintains a delicate balance between excitatory neurons and inhibitory interneurons. Previous studies, including our own researc...
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Kristina Micheva @kdmicheva.bsky.social · 22/11/2024
This is fun 🦋 With help from Scholar Goggler scholargoggler.com
my word cloud, prominently featuring array tomography in big yellow letters, all things synaptic in blue and red, and a colorful cloud of other brain and imaging keywords
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Reposted by Kristina Micheva
Christophe 🔬 Leterrier @christlet.bsky.social · 19/11/2024
Best thing you could watch in 2016 and best thing you can watch today. RIP Thomas Reese
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Kristina Micheva @kdmicheva.bsky.social · 19/11/2024
Celebrating the small (70 nm) victories today - look at these perfect serial sections that I cut! 🧪 the joys of #arraytomography
A shiny, perfectly straight ribbon of serial trapezoid sections floating in the water bath of a diamond knife. These are sections from a mouse brain embedded in plastic, each section is 70 nm thin!A closeup of an ultramicrotome and the diamond knife used for cutting the ultrathin sections. There's a beautiful long ribbon of sections floating in the middle of the diamond knife boat and a coverslip is propped in, ready to pick the ribbon.
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Kristina Micheva @kdmicheva.bsky.social · 13/11/2024
I'm here, who else?
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Kristina Micheva @kdmicheva.bsky.social · 12/11/2024
Time for some of my favorite images with immunofluorescence array tomography: this one is human cortex, and the yellow fluff around the blue nuclei are lipofuscin granules that accumulate with aging. Lipofuscin in this image comes for free - no label needed because it is autofluorescent!
Immunofluorescence array tomography image from human cortex. Several colorful neurons can be seen.This is a volume reconstruction from ~30 serial sections, 70 nm each, that were labeled with three different antibodies. Yellow lipofuscin granules surround the blue nuclei of some of the neurons.
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Kristina Micheva @kdmicheva.bsky.social · 08/11/2024
Delicious & unique array tomography cake from the Array Tomography Workshop in Munich 2024. Thank you!
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Kristina Micheva @kdmicheva.bsky.social · 17/11/2023
Color-coordinated EM. Chapter 2. Autumn synapses with #webknossos
Computer screens showing electron microscopy of brain tissue overlaid with immunofluorescence for synaptic markers; the color palette inspired by the beautiful autumn colors of the trees outside the window.
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Kristina Micheva @kdmicheva.bsky.social · 24/08/2023
There are places / communities / ecosystems that are so difficult to leave and keep pulling you back Woods Hole, MBL
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Kristina Micheva @kdmicheva.bsky.social · 16/08/2023
Found in the Lillie library, MBL - interesting dynamics of the languages used in early zoological literature and here's the actual reference: doi: 10.3897/zookeys.550.10041
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Kristina Micheva @kdmicheva.bsky.social · 11/08/2023
Perfect occasion for my first post here: Lab with a view - talk done - great to be back at MBL!
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