Reposted by Kaz 🪰♥️🔬 🇯🇵
Cool new paper from @joshdubnau.bsky.social
Early life social isolation primes flies for rapid neurodegeneration later in life.
www.biorxiv.org/content/10.6...
biorxiv.org
Early life social isolation primes flies for more rapid TDP-43 dependent neurodegeneration later in life.
A key pathophysiological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is loss of nuclear localization and abnormal cytoplasmic aggregation of TAR DNA-binding prote...