Reposted by @kateonuska.bsky.socialVeronica Diveica @veronicadiveica.bsky.social · 14/07/2026The default network is often thought to interfere with the selective deployment of attention—but our new @pnas.org paper shows a different story… 👉 Find the paper here: doi.org/10.1073/pnas... 1/🧵 2427
kateonuska.bsky.social @kateonuska.bsky.social · 19/06/2026Finally, we articulate an urgent and unmet need for in vivo cholinergic biomarkers to deepen our knowledge of the timing and progression of BFCN dysfunction. Understanding such events will be critical for identifying new avenues for therapeutic development. (4/4) 000
kateonuska.bsky.social @kateonuska.bsky.social · 19/06/2026We then review existing evidence suggesting that the heightened vulnerability of BFCNs further aggravates the progression of Aβ, tau, and neuroinflammatory species, contributing to the spread of pathophysiological signatures to functionally and anatomically connected brain regions. (3/4) 100
kateonuska.bsky.social @kateonuska.bsky.social · 19/06/2026We first propose that innate morphofunctional BFCN vulnerabilities, established in both evolution and development, interact with midlife stressors to trigger a cascade of events that contribute to BFCN dysfunction and degeneration. (2/4) 100
kateonuska.bsky.social @kateonuska.bsky.social · 19/06/2026Heading into #ISCM2026, we are excited to share that our review is now out in @alzdemjournals.bsky.social! We synthesize evidence across several fields of neuroscience to present a lifespan staging model of basal forebrain cholinergic neuronal (BFCN) vulnerability doi.org/10.1002/alz.... (1/4)doi.orgA lifespan staging model of basal forebrain cholinergic vulnerabilityThe cholinergic neurons of the basal forebrain are among the most vulnerable cell types to age- and Alzheimer's disease-related dysfunction and neurodegeneration. However, the biological bases of bas.... 131
kateonuska.bsky.social @kateonuska.bsky.social · 04/05/2026@northernthrux.bsky.social with a timely Feindel lecture opening! #gohabsgo 161
Reposted by @kateonuska.bsky.socialMarco A. Maximo Prado @maximoprado.bsky.social · 19/03/2026fire away @kateonuska.bsky.social #adpd2026 041
Reposted by @kateonuska.bsky.socialAlfie Wearn @alfiewearn.bsky.social · 10/03/2026Neuromodulatory neurons are extremely susceptible to stress. I argue that their fragility is an inherent weak point, the breaking of which directly leads to Alzheimer’s Disease. I discuss this idea and its implications in a recently published perspective piece: dx.doi.org/10.1002/alz....dx.doi.orgThe neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesisSporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factor... 175
Reposted by @kateonuska.bsky.socialMarco A. Maximo Prado @maximoprado.bsky.social · 23/08/2025Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...onlinelibrary.wiley.comA Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor DeficitsAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by abnormal accumulation of the RNA-binding protein TDP-43. Using a mouse model that mildly overexpresses human ... 094
Reposted by @kateonuska.bsky.socialMarco A. Maximo Prado @maximoprado.bsky.social · 24/07/2025Hot off the press Huge congrats to Alycia Crook a PhD student from the lab www.nature.com/articles/s41...nature.comCharacterization of a novel transgenic mouse model to investigate brain-wide activation of astrocyte Gq signaling - Lab AnimalThis study uses a transgenic mouse line expressing Cre-inducible astro-hM3Dq to study astrocytes’ role in neuroinflammation and cognition without the use of viral transduction, mitigating the potentia... 0114
Reposted by @kateonuska.bsky.socialMarco A. Maximo Prado @maximoprado.bsky.social · 13/06/2025Grad student extraordinaire @kateonuska.bsky.social dropped this preprint www.biorxiv.org/content/10.1... using multimodal imaging, behavior, 🐁 and human datasets to show how cholinergic plasticity regulates resilience to Alzheimer’s pathology. Led by Taylor Schmitz 🧪biorxiv.orgCholinergic synaptic plasticity shapes resilience and vulnerability to tauSynaptic dysfunction is a hallmark of Alzheimer’s disease (AD). Yet due to their plasticity, synapses may also adapt to early AD pathology. Using within-subject positron emission tomography scans targ... 1142
