T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive aerobic glycolysis. Rer...

y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...