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Luca Jovine

@jovinelab.org

228 followers 195 following 63 posts

Professor of #StructuralBiology @karolinskainst.bsky.social studying #egg-#sperm interaction at #fertilization & #ZonaPellucida (ZP) module proteins Member of #EMBO & the #NobelAssembly at Karolinska Institutet More @ jovinelab.org

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Luca Jovine @jovinelab.org · 06/07/2026

Looking forward to talk about egg coat structure and egg-sperm interaction @eshre.bsky.social 2026! #ESHRE2026 #zp #egg #sperm #fertilization #zonapellucida

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Luca Jovine @jovinelab.org · 21/04/2026

Fun to talk about how #AlphaFold and #ROCKET can help #crystallography and #cryoEM studies of #fertilization at this year's American Society of Andrology meeting in Phoenix! andrologysociety.org/annual-meeti... #ASA #reproductivebiology #andrology

American Society of Andrology 2026 (ASA 2026)

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Luca Jovine @jovinelab.org · 01/04/2026

Ultimately, this helped us determine the first cryo-EM structure of a native vertebrate egg coat filament (www.rcsb.org/structure/28YJ):

Cryo-EM structure of a native ZP filament

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Luca Jovine @jovinelab.org · 01/04/2026

Starting from an #AlphaFold-Multimer prediction, we used #ROCKET to build a model of ZPD, a homopolymeric zona pellucida (#ZP) protein, into an initial #cryo-EM map at only ~9 Å resolution. A subsequently obtained 4.6 Å map highlighted how superior the ROCKET model was over the initial prediction:

ROCKET enables model building of a ZPD filament from low-resolution cryo-EM

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Luca Jovine @jovinelab.org · 16/02/2026

Delighted to deliver an invited lecture at this year's TI-FRIS/FRIS Symposium in Sendai! A highly interdisciplinary meeting bringing together diverse fields through excellent science: lnkd.in/d5XqH7ZV

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Luca Jovine @jovinelab.org · 24/01/2026

Thrilled to announce that the GRC Fertilization and Activation of Development and associated GRS will come to Europe for the first time in 2027! Join us in Noordwijk, the Netherlands, 31 July–6 August 2027. Mark your calendars and help us spread the word! #GRC #GRS #Fertilization #Development

GRC Fertilization and Activation of Development 2027 announcement

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Luca Jovine @jovinelab.org · 10/11/2025

Excited to attend this #SMART symposium on protein science in impressive Shenzhen!

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Luca Jovine @jovinelab.org · 22/07/2025

Excited that the Gordon Research Conference on Fertilization and Activation of Development 2025 (and associated GRS) is just a few days away! www.grc.org/fertilizatio... www.grc.org/fertilizatio... #GRC #GRS #fertilization #development #egg #sperm

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Luca Jovine @jovinelab.org · 12/12/2024

Happy to bring the #ZP2 and egg coat filament story to HZB BESSY, where one the key datasets was collected!

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Luca Jovine @jovinelab.org · 10/12/2024

Here we go!

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