iiinova — where your digital self keeps evolving

Reposted by Joshua Fein

Mark A. Hanson @hansonmark.bsky.social · 17/07/2026

"AI enthusiasts are telling the world that the remedies should all be easy to automate, creating the impression that journals can not only catch more errors but also do it more efficiently and cheaply. That’s not the reality for scientific publishing right now or likely in the future."

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Joshua Fein @joshuafein.bsky.social · 13/07/2026

@anthropic.com — glad to hear this… but I still can’t try Fable even for the most mundane tasks (like planning a family trip! I swear no science!!) because I work in medicine. Any progress in allowing specific use cases? Or a screening process to allow use in biomedical research?🙏

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Reposted by Joshua Fein

Kate Markey @kate-fisher.bsky.social · 16/06/2026

Looking for a new postdoc to join my lab at the Fred Hutch in Seattle. Keen to find someone excited to dive into the mechanisms underlying microbial control of immune system recovery after transplant and immunotherapy! careers-fhcrc.icims.com/jobs/31336/p...

careers-fhcrc.icims.com

Fred Hutchinson Cancer Center

Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

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Joshua Fein @joshuafein.bsky.social · 18/12/2025

Looks like @wolverheme.bsky.social @berninini.bsky.social Justin Kaner are still predominantly in the old place — this is a don’t miss episode for anyone interested in the present and future of acute leukemia. podcasts.apple.com/us/podcast/w...

podcasts.apple.com

ASH Leukemia Review: the more we learn, the less we know!

Podcast Episode · WolverHeme Happy Hour · 12/17/2025 · 1h 23m

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Joshua Fein @joshuafein.bsky.social · 14/11/2025

Outstanding articles. I’ve only just begun experimenting with Claude and Gemini CLIs and they’re incredibly powerful. This is extremely valuable best practice advice.

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Reposted by Joshua Fein

Jeremy Berg @jeremymberg.bsky.social · 08/11/2025

Bluetorial-Jim Watson I met Jim Watson a few times but did not know him well. However, I was greatly influenced by his book “The Double Helix”. He was a complicated human being with some very, very bad features, but some good contributions. What follows is my personal perspective. 1/41

media.tenor.com

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

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Joshua Fein @joshuafein.bsky.social · 07/11/2025

My favorite feature of the @developers.google.com Gemini CLI is the snarky comments while it's working on something... especially "Rewriting in Rust for no particular reason."

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Joshua Fein @joshuafein.bsky.social · 07/11/2025

Proper way to start the day.

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Joshua Fein @joshuafein.bsky.social · 16/10/2025

Congrats to the authors on this huge accomplishment. Fascinating and so much to build on here.

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Joshua Fein @joshuafein.bsky.social · 13/08/2025

Has anyone had success 3D printing storage boxes for -80s? What fiber have you used? any special settings to reinforce? I'm thinking of making either custom inserts or entire boxes to better keep track of which sample goes where...

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Reposted by Joshua Fein

Ben Langmead @benlangmead.bsky.social · 29/05/2025

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

en.wikipedia.org

HMMER - Wikipedia

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Joshua Fein @joshuafein.bsky.social · 27/04/2025

Reminds me of Oliver Sacks’ musings on seeing azure. This will surely be commercialised and available as an “experience” (hopefully safely) around the world soon, but absolutely sign me up.

theatlantic.com

The ‘Profound’ Experience of Seeing a New Color

The ecstasy of “olo”

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Joshua Fein @joshuafein.bsky.social · 23/04/2025

I think the reason I like #systemsimmunology #cshlsysimm is because network diagrams are so pretty.

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Joshua Fein @joshuafein.bsky.social · 18/04/2025

Does anyone have experience with momelotinib for AGvHD in MF patients?

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Reposted by Joshua Fein

Simone Minnie @simone-minnie.bsky.social · 17/04/2025

I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested! aprecruit.ucsf.edu/JPF05438

aprecruit.ucsf.edu

Minnie Lab - Junior, Assistant, or Associate Specialist

University of California, San Francisco is hiring. Apply now!

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Joshua Fein @joshuafein.bsky.social · 16/04/2025

Excited to attend #cshlsysimm next week. I am just starting to find my way in this fascinating field and look forward to learning from the extraordinary lineup of speakers! Please reach out if you’ll be there—looking forward to connecting. @cshlnews.bsky.social

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Joshua Fein @joshuafein.bsky.social · 11/04/2025

I remain strongly in favor of fishing expeditions.

mad scientist wearing a bowtie fishing and catches a beaker of orange bubbling liquid

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Joshua Fein @joshuafein.bsky.social · 09/04/2025

In light of recent news regarding funding, I have asked ChatGPT to help figure out how to do ATAC-Seq with only an abacus and stone tools.

Neolithic people working with mortar and pestle on an ATAC-seq analysis. An older man holds a bottle labeled Tn5 Transposase

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Reposted by Joshua Fein

Asma Farhat @asmafarhat.bsky.social · 28/03/2025

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis. 🔗 www.science.org/doi/10.1126/...

science.org

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence

Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

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Joshua Fein @joshuafein.bsky.social · 20/03/2025

It dawned on me today that I really should’ve named one of my kids Luke, so that I could legitimately say “Luke, I am your father.” Oh well.

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Reposted by Joshua Fein

danapeer.bsky.social @danapeer.bsky.social · 07/03/2025

1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...

biorxiv.org

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer

Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic ...

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Joshua Fein @joshuafein.bsky.social · 06/03/2025

Having determined that the transplant immunology community is shamefully lacking for pompously named journals, I propose the establishment of Acta Transplantiana A (solid organs) and B (haematopoietic tissues). Paper distribution only, on heavy cream-coloured paper stock. Figures hand-drawn.

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Joshua Fein @joshuafein.bsky.social · 01/03/2025

I am struck by the aptness of Fareed Zakaria’s description of the United States in this conversation with @ezraklein.bsky.social We are determined to devour the world that we created. podcasts.apple.com/us/podcast/t...

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Joshua Fein @joshuafein.bsky.social · 23/02/2025

Anyone have a nice public dataset of shotgun gut microbiome data specifically in GU malignancies treated with checkpoint inhibitors? Looking for something with published OS or PFS data for a little validation. Much obliged!

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Reposted by Joshua Fein

Prof Sheena Cruickshank @sheencr.bsky.social · 22/02/2025

More attacks on US science by stealth as new research grants still frozen! Grants issued via 2 step process- one to assess science via science board and one a grant review step with a membership of a wider board that get final approval to sign the money of based upon initial recommendation 🧪🧵

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Joshua Fein @joshuafein.bsky.social · 17/02/2025

What a wonderful #Tandem25! As always, the best of the conference is in the conversations and brainstorming between and outside the sessions; so wonderful to reconnect with mentors, friends, acquaintances from around the world in one of the most beautiful places I have ever visited.

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Reposted by Joshua Fein

Aaron Logan, MD, PhD, MPhil @hemedoc.bsky.social · 15/02/2025

#tandem25 #bmtsm Abrams: exclusion from HCT/CT most commonly due to lack of insurance, unhoused, medication non-adherence, and substance abuse. Broad variability in abstinence time requirements. Top center-reported barriers to all HCT/CT were lack of caregiver and housing concerns.

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Reposted by Joshua Fein

@ouholter @ouholter.bsky.social · 14/02/2025

Enough said. Decisions matter.

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Reposted by Joshua Fein

Aaron Logan, MD, PhD, MPhil @hemedoc.bsky.social · 12/02/2025

#tandem25 #bmtsm Arnhold: we aren’t at the point where we can abandon steroids in aGVHD, but it’s as clear as ever that that needs to be a high priority for innovation in GVHD care.

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Reposted by Joshua Fein

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 04/02/2025

Take advantage of the opportunity to speak at the Mini Symposium by submitting an abstract by 26 February. Learn how and register today ➡️ buff.ly/3WLixTV

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Joshua Fein @joshuafein.bsky.social · 17/01/2025

Anyone have a secret stash of brincidofivir they can share? FDA will release for monkeypox but not for adenovirus. Just in case we have a global smallpox outbreak and need every last dose from the strategic national stockpile.

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Reposted by Joshua Fein

Aino-Maija Leppä @amleppa.bsky.social · 25/11/2024

Extremely proud to see my PhD project exploring intra-tumor heterogeneity in complex karyotype AML finally out in @NatureGenet! 🎉 👩🏻‍🔬 They say that 10,000 hours make you an expert, so I guess after more than five years of work I’m half-way there 😅 ⬇️1/5 www.nature.com/articles/s41...

nature.com

Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype - Nature Genetics

An integrated single-cell multiomic analysis of complex karyotype acute myeloid leukemia characterizes intratumoral heterogeneity and highlights links to therapeutic sensitivities.

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Joshua Fein @joshuafein.bsky.social · 04/01/2025

This looks intriguing and conveniently well timed for me to test on a dataset I’m playing with. Anyone have experience with this tool from a preprint or whatnot and have reflections to share?

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Reposted by Joshua Fein

Itai Yanai @itaiyanai.bsky.social · 29/12/2024

The big 4 of grant writing: 1. Credibility: The topic fits your expertise 2. Narrative: It's clear what is the problem, the solution, and why you’re the right person for it 3. Juicy details: Flex your mastery of the topic 4. The concept: You connect every part to the big question

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Reposted by Joshua Fein

Shematologist, MD @shematologist.medsky.social · 28/12/2024

Many pediatric oncology programs rely on philanthropy and have just a small fraction of the resources that St Jude has. If you’d like to support children with cancer, especially those in your area, consider donating to your local children’s hospital.

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Joshua Fein @joshuafein.bsky.social · 27/12/2024

Whether you’re a seasoned pianist, occasional classical music listener (“background music”) or resolute in your belief that there was no such thing as music before 1968… I implore you to take an hour to listen to this segment of the Chopin Podcast, *working through* the Barcarolle. Brilliant.

youtube.com

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Joshua Fein @joshuafein.bsky.social · 25/12/2024

OUTSTANDING #ASH24 roundup of lymphoma (esp. MCL) abstracts. Is auto dead for MCL? And… not addressed, should we still consider (early) allo for young high-risk? @ash-hematology.bsky.social @berninini.bsky.social (can’t find Anthony Perissinotti or Tycel Phillips here yet? Please tag if they are!)

podcasts.apple.com

Pour Decisions, or ASH-olutely Fabulous? Reviewing 2024 ASH Lymphoma Updates

Podcast Episode · WolverHeme Happy Hour · 12/24/2024 · 1h 4m

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