A major challenge in human evolutionary biology is to pinpoint genetic differences that underlie human-specific traits, such as increased neuron number and differences in cognitive behaviors. We used ...

In a recent episode of the podcast series Lab Talk by The Scientist, guest speaker Josh Tycko’s excitement was infectious. Tycko, a postdoctoral researcher at Harvard Medical School, spoke about how f...

A study uses single-molecule footprinting to measure protein occupancy at regulatory elements on individual molecules in human cells and describes how different properties of transcription factor bind...

Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.