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Josh Searle

@joshsearle.bsky.social
96 followers 181 following 1 posts

Cancer cell biologist; pleural mesothelioma and lung cancer; postdoc in Janes lab @ UCL Respiratory Medicine; PhD in Malliri lab @ UoM

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Josh Searle @joshsearle.bsky.social · 23/04/2026
New paper from my PhD work on the E3 ubiquitin ligase HUWE1 in lung cancer, now out in Cell Death & Disease. We show that HUWE1 is required for KRAS-driven tumour growth and that targeting it induces tumour cell senescence and tumour regression. 🔗 www.nature.com/articles/s41...
nature.com
The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer - Cell Death & Disease
Cell Death & Disease - The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer
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Reposted by Josh Searle
Journal of Cell Science @jcellsci.bsky.social · 17/04/2025
Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells. journals.biologists.com/jcs/article/... journals.biologists.com/jcs/article/...
Graphs and micrographs investigating Wnt pathway activating compounds as promoters of airway basal cell proliferation.
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Reposted by Josh Searle
Sandra GL @sandra-gl.bsky.social · 02/05/2025
Our work describing the biological mechanisms driving the formation of a cancerized field in the airways is now out @science.org! Huge team effort from @lungs4living.bsky.social and amazing collaborators to delineate the origin of precancerous lung disease 🫁 www.science.org/doi/full/10....
science.org
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Reposted by Josh Searle
Tom Newsom-Davis @tnewsomdavis.bsky.social · 09/12/2024
Full house for @BTOGORG Mesothelioma Essential Update 2024 @DrRiyazShah in charge Fantastic energy & enthusiasm for a bright December morning Looking forward to a day of education and networking 👊
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Reposted by Josh Searle
Kevin Blyth @kevingblyth.bsky.social · 15/11/2024
On Wednesday this week we hosted our first PREDICT-Meso Young Investigators’ Day in Glasgow. Blown away by the progress and quality of our PhD students & postdocs. The future of #mesothelioma research looks bright! @cruk-si.bsky.social @uofglasgow.bsky.social @djmurphylab2.bsky.social
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