Mycobacteria have long posed a threat to human health, being responsible for a range of hard-to-treat infections such as tuberculosis, leprosy, and other chronic diseases caused by nontuberculous…

Author summary Lomentospora prolificans is recognized as a priority fungal pathogen by the World Health Organization due to its rising clinical significance to cause life-threatening infections that a...

First Summer International Advanced Biophysics and Structural Biology Course. Eva Nogales - Carlos Bustamante.

Here, we present a protocol for an automated virtual screening pipeline. We describe steps for generating compound libraries for computational docking including Food and Drug Administration (FDA)-approved drugs, setting up the receptor and grid box, and docking a library of compounds. We then detail procedures for ranking docking results. This protocol offers scripts for Unix-like systems, lowering the access barrier for researchers interested in structure-based drug disc...

Assistant Professor Pablo Alcón from the Department of Molecular Biology and Genetics has received a three-year Knæk Cancer grant of DKK 3.6 million from the Danish Cancer Society. The project aims to...

Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.

Abstract. The glucocorticoid receptor (GR) is a leading drug target due to its antiinflammatory and immunosuppressive roles. The functional oligomeric conf